• Developing techniques for proton MR spectroscopy of the liver which do not suffer from respiratory motion artifacts

• Understanding the roles in and out of phase MR imaging, proton MR spectroscopy, and MR diffusion weighting imaging play in detecting fatty liver disease and in discriminating among grades of steatosis, inflammation, and fibrosis.

• Using HRMAS spectroscopy of liver biopsy or other liver tissue samples to understand the MR visible compounds in normal and diseased liver

Grants

• “Quantification of Hepatic Steatosis and Fibrosis in HIV/HCV-coinfected Men and Women using Magnetic Resonance Imaging, Spectroscopy, and Diffusion: a pilot study” Principal Investigator: Phyllis Tien. Agency: NIH. 2/04 – 1/07
• “Novel Magnetic Resonance Imaging and Spectroscopy in the Non-Invasive Histologic Evaluation Of Non-Alcoholic Fatty Liver Disease” - part of the NASH Clinical Research Network NIDDK Oct 2004 – Sept 2005.
• “Quantification of Hepatic Steatosis Using Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Compared to Liver Biopsy in HIV/HCV Co-Infected Women: A Pilot Study." Principal Investigator: Phyllis Tien, M.D. Agency: UCSF Moffit GCRC. Fall 2003 – Fall 2004.
• “MR Imaging and H1-MR spectroscopy of the Liver in Non-alcoholic Steatohepatitis: Imaging-Histopathologic Correlation” Principal Investigator: Aliya Qayyum, M.D. Agency: UCSF Radiology Department Internal Funding January 2003 – December 2003.
• “Non-Invasive Evaluation of Pathology and Prediction of Outcome in Non-Alcoholic Fatty Liver Disease: Role of MR Imaging and Spectroscopy.” Principal investigator: Aliya Qayyum M.D. Agency: 2003 Wylie J. Dodds Award, Society of Gastrointestinal Radiologists. Spring 2003 – Spring 2004.

Gynecologic Cancer
• “Role of Endovaginal Dynamic Contrast-Enhanced MR Imaging in Cervical Cancer” Principal Investigator: Aliya Qayyum, M.D. Agency: UCSF Radiology Department Internal Funding 2005 - present.