Soonmee Cha, MD

Professor, Vice Chair for Education
Program Director, Diagnostic Radiology Residency
Associate Program Director, Integrated Interventional Radiology Residency
Professor in Residence
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Biography

Soonmee Cha, MD, is a Professor In Residence of Radiology and Neurological Surgery at the University of California, San Francisco. She is the Diagnostic Radiology Residency Program Director, and she is Radiology's Vice-Chair of Education. Dr. Cha has focused on the importance of validating the usefulness of MRI as a tool for brain tumor diagnosis, monitoring and identifying therapy endpoints. She obtained her medical degree from Georgetown University, School of Medicine, Washington in 1991. She completed her Diagnostic Radiology residency from North Shore University Hospital, Cornell University Medical College in New York, followed by a fellowship in Neuroradiology from New York University Medical Center in 1998.

Dr. Cha is committed to a career dedicated to patient-oriented research in the field of brain tumor imaging. She believes that non-invasive imaging technology will make important contributions to the health of patients through improving the specificity and precision of diagnosis and treatment monitoring, which will have significant impact on therapeutic decisions.

The main focus of Dr. Cha’s research is to identify reliable surrogate markers of prognosis and therapeutic efficacy by quantitative MR imaging methods in patients with brain tumors. She believes that by using MR imaging techniques such perfusion MR imaging, diffusion-weighted imaging, and 3-dimensional proton magnetic resonance spectroscopic imaging, detection of changes in tumor angiogenesis, cellularity, invasion, tumor hypoxia, and metabolic burden can be accurately measured and will provide more specific information about patient’s early response to therapy in the context of tumor growth.

Dr. Cha has been awarded several NIH grants, serving as Principal Investigator and Co-Principal Investigator on many NIH projects. She has published 87 articles, and she has written 77 peer-reviewed articles and 4 book chapters.

Expertise:
Neuroradiology

Specialty:
Brain tumor imaging

Professional Interests:
Brain tumor, brain cancer, glioblastoma multiforme, gliomas, primary cerebral lymphoma, angiogenesis, hypoxia, invasion, perfusion MR imaging, diffusion-weighted imaging, molecular imaging, biomarkers, microarray, genomics, neural stem cell

Education and Training:
• Medical School: Georgetown University, College of Arts and Sciences, Washington, District of Columbia
• Internship: Georgetown University Fairfax Hospital, Falls Church
• Residency: North Shore University Hospital, Cornell University Medical College, Manhasset, New York - Diagnostic Radiology
• Fellowship: New York University Medical Center, New York - Neuroradiology

Honors and Awards

Ranked #1 Diagnostic Radiology Residency Program in the Country, Doximity and U.S. News & World Report, 2014
Educational Exhibit-Cum Laude Award, Radiological Society of North America, 2014
Excellence and Innovation in Graduate Medical Education Award, University of California, San Francisco, 2014
Educational Exhibit Cum Laude Award, Radiological Society of North America, 2013
Hideyo Minagi Outstanding Teacher Award, University of California, San Francisco Department of Radiology and Biomedical Imaging, 2013
Hideyo Minagi Outstanding Teacher Award, University of California, San Francisco Department of Radiology and Biomedical Imaging, 2010
Best Doctor's, 2009-2013
Best Speaker Award, FMRI/DTI/PWI Morning Categorical Course, International Society of Magnetic Resonance in Medicine, 2006
Scholar Award in Neuroradiology Research, American Society of Neuroradiology Foundation Scholar, 2001
ASNR Outstanding Presentation Award in General Neuroradiology, American Society of Neuroradiology, 2000
RSNA Certificate of Merit Award, Radiological Society of North America, 1995
RSNA Certificate of Merit Award, Radiological Society of North America, 1994

Publications

Reddy S, Cha S, LaHue SC. Clinical Reasoning: A 22-Year-Old Man With Multifocal Brain and Osseous Lesions. Neurology. 2023 Nov 27; 101(22):1025-1031.
Isikbay M, Carrodeguas E, Tatem A, Cha S. Challenges of Preparing for Diagnostic Radiology Call. Radiology. 2023 09; 308(3):e230421.
Cha SM, Kim YK, Shin HD, Park JY, Lee SH. Importance of Whole-Body Scintigraphy or Positron Emission Tomography for Early Detection of Femoral Lesions in Breast Cancer Patients Treated with Bisphosphonates. Clin Orthop Surg. 2023 Aug; 15(4):659-667.
LaHue SC, Guterman EL, Mikhail M, Li Y, Cha S, Richie MB. Clinical and Radiographic Characteristics of Nocardia vs Non-Nocardia Brain Abscesses. Neurol Clin Pract. 2023 Apr; 13(2):e200134.
Calabrese E, Villanueva-Meyer JE, Rudie JD, Rauschecker AM, Baid U, Bakas S, Cha S, Mongan JT, Hess CP. The University of California San Francisco Preoperative Diffuse Glioma MRI Dataset. Radiol Artif Intell. 2022 Nov; 4(6):e220058.
Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen AW, Aghi MK, Theodosopoulos P, Chang EF, Hervey-Jumper SL, Berger MS, Clarke JL, Chang SM, Molinaro AM, Solomon DA. Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes. Neuro Oncol. 2022 10 03; 24(10):1749-1762.
Rudie JD, Calabrese E, Saluja R, Weiss D, Colby JB, Cha S, Hess CP, Rauschecker AM, Sugrue LP, Villanueva-Meyer JE. Longitudinal Assessment of Posttreatment Diffuse Glioma Tissue Volumes with Three-dimensional Convolutional Neural Networks. Radiol Artif Intell. 2022 Sep; 4(5):e210243.
Calabrese E, Rudie JD, Rauschecker AM, Villanueva-Meyer JE, Clarke JL, Solomon DA, Cha S. Combining radiomics and deep convolutional neural network features from preoperative MRI for predicting clinically relevant genetic biomarkers in glioblastoma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac060.
Carrete LR, Young JS, Cha S. Advanced Imaging Techniques for Newly Diagnosed and Recurrent Gliomas. Front Neurosci. 2022; 16:787755.
Richie MB, Guterman EL, Shah MP, Cha S. Susceptibility-Weighted Imaging of Intravascular Lymphoma of the Central Nervous System. JAMA Neurol. 2022 01 01; 79(1):86-87.
Lucas CG, Gupta R, Wu J, Shah K, Ravindranathan A, Barreto J, Gener M, Ginn KF, Prall OWJ, Xu H, Kee D, Ko HS, Yaqoob N, Zia N, Florez A, Cha S, Perry A, Clarke JL, Chang SM, Berger MS, Solomon DA. EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma. Acta Neuropathol. 2022 01; 143(1):109-113.
Morshed RA, Lee AT, Wang EJ, Young JS, Cha S, Hervey-Jumper SL, Berger MS. Functional outcomes after resection of middle frontal gyrus diffuse gliomas. J Neurosurg. 2021 Nov 19; 1-8.
Li Y, Sloan E, Bollen A, Solomon D, Theodosopoulos P, Cha S. Systemic and Craniospinal Rosai Dorfman Disease with Intraparenchymal, Intramedullary and Leptomeningeal Disease. Int J Hematol Oncol Stem Cell Res. 2021 Oct 01; 15(4):260-264.
Lee WY, Shin HD, Kim KC, Cha SM, Jeon YS. Relationship between incidence of postoperative radial nerve palsy and surgical experience in the treatment of humeral shaft fractures through a posterior triceps splitting approach: A retrospective study. Acta Orthop Traumatol Turc. 2021 Aug; 55(4):338-343.
Calabrese E, Rudie JD, Rauschecker AM, Villanueva-Meyer JE, Cha S. Feasibility of Simulated Postcontrast MRI of Glioblastomas and Lower-Grade Gliomas by Using Three-dimensional Fully Convolutional Neural Networks. Radiol Artif Intell. 2021 Sep; 3(5):e200276.
Lee WY, Shin HD, Kim KC, Cha SM, Jeon YS, Kim DH. Open Reduction and Stable Internal Fixation Using a 3.5-mm Locking Hook Plate for Isolated Fractures of the Greater Tuberosity of the Humerus: A 2-Year Follow-up Study Using an Innovative Fixation Method. Clin Orthop Surg. 2021 Sep; 13(3):293-300.
Cluceru J, Nelson SJ, Wen Q, Phillips JJ, Shai A, Molinaro AM, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Chunduru P, Villanueva-Meyer JE, Cha S, Chang SM, Berger MS, Lupo JM. Recurrent tumor and treatment-induced effects have different MR signatures in contrast enhancing and non-enhancing lesions of high-grade gliomas. Neuro Oncol. 2020 10 14; 22(10):1516-1526.
Choi ES, Cha SM, Shin HD. Autogenous Bone Graft With Kirschner Wire Fixation Could Be a Reliable Treatment Option for Scaphoid Nonunion in Adolescents. J Pediatr Orthop. 2020 Sep; 40(8):e708-e711.
Calabrese E, Villanueva-Meyer JE, Cha S. A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas. Sci Rep. 2020 07 16; 10(1):11852.
Cha SM, Shin HD. Features of the Ulnar Nerve Predicting Postoperative Prognosis in Idiopathic Cubital Tunnel Syndrome: Three Distinct Features of the Ulnar Nerve. Ann Plast Surg. 2020 07; 85(1):50-55.
Cha SM, Shin HD, Choi ES. Long-term outcomes of distal humeral epiphyseal separations treated via closed reduction and pinning under arthrogram. Injury. 2020 Feb; 51(2):207-211.
Young JS, Morshed RA, Mansoori Z, Cha S, Berger MS. Disruption of Frontal Aslant Tract Is Not Associated with Long-Term Postoperative Language Deficits. World Neurosurg. 2020 Jan; 133:192-195.
Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA. Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019 11; 138(5):877-881.
Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol. 2020 01; 30(1):46-62.
Cha SM, Shin HD, Kim KH, Kim JH. Histological Evidence of Intrinsic Muscle Degeneration in Compression Ulnar Neuropathy. Ann Plast Surg. 2019 05; 82(5):541-545.
Cha SM, Shin HD, Song SH. Cross-sectional Area Just Proximal to the Carpal Tunnel According to the Ulnar Variances: Positive Ulnar Variance and Carpal Tunnel Syndrome. Ann Plast Surg. 2019 01; 82(1):76-81.
Behr SC, Villanueva-Meyer JE, Li Y, Wang YH, Wei J, Moroz A, Lee JK, Hsiao JC, Gao KT, Ma W, Cha S, Wilson DM, Seo Y, Nelson SJ, Chang SM, Evans MJ. Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR. JCI Insight. 2018 11 02; 3(21).
Aoki Y, Ochiai K, Lim S, Aoki D, Kamiura S, Lin H, Katsumata N, Cha SD, Kim JH, Kim BG, Hirashima Y, Fujiwara K, Kim YT, Kim SM, Chung HH, Chang TC, Kamura T, Takizawa K, Takeuchi M, Kang SB. Phase III study of cisplatin with or without S-1 in patients with stage IVB, recurrent, or persistent cervical cancer. Br J Cancer. 2018 08; 119(5):530-537.
Merritt BA, Henry TS, Cha S, Ordovas KG, Kallianos KG, Elicker BM, Hope MD, Naeger DM. Tailoring Radiology Resident Education Using Aggregated Missed-Cases Data. J Am Coll Radiol. 2018 Jul; 15(7):1013-1015.
Aboian MS, Kline CN, Li Y, Solomon DA, Felton E, Banerjee A, Braunstein SE, Mueller S, Dillon WP, Cha S. Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging. Neurooncol Pract. 2018 Nov; 5(4):234-240.
Villanueva-Meyer JE, Wood MD, Choi BS, Mabray MC, Butowski NA, Tihan T, Cha S. MRI Features and IDH Mutational Status of Grade II Diffuse Gliomas: Impact on Diagnosis and Prognosis. AJR Am J Roentgenol. 2018 Mar; 210(3):621-628.
Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903.
Villanueva-Meyer JE, Mabray MC, Cha S. Current Clinical Brain Tumor Imaging. Neurosurgery. 2017 Sep 01; 81(3):397-415.
Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S. Case-based review: pediatric medulloblastoma. Neurooncol Pract. 2017 Sep; 4(3):138-150.
Tremblay MA, Villanueva-Meyer JE, Cha S, Tihan T, Gelfand JM. Clinical and imaging correlation in patients with pathologically confirmed tumefactive demyelinating lesions. J Neurol Sci. 2017 Oct 15; 381:83-87.
Cha SM, Choi BS, Shin HD. Radiological degenerative changes in the distal radioulnar joint after ulnar shortening osteotomy in patients with idiopathic ulnar impaction syndrome: Analysis of factors affecting degenerative lesions. J Orthop Sci. 2017 Nov; 22(6):1042-1048.
Villanueva-Meyer JE, Han SJ, Cha S, Butowski NA. Early tumor growth between initial resection and radiotherapy of glioblastoma: incidence and impact on clinical outcomes. J Neurooncol. 2017 Aug; 134(1):213-219.
Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709.
Li Y, Ali S, Clarke J, Cha S. Bevacizumab in Recurrent Glioma: Patterns of Treatment Failure and Implications. Brain Tumor Res Treat. 2017 Apr; 5(1):1-9.
Cha SM, Shin HD, Ahn KJ. Prognostic Factors Affecting Union After Ulnar Shortening Osteotomy in Ulnar Impaction Syndrome: A Retrospective Case-Control Study. J Bone Joint Surg Am. 2017 Apr 19; 99(8):638-647.
Ehman EC, Johnson GB, Villanueva-Meyer JE, Cha S, Leynes AP, Larson PEZ, Hope TA. PET/MRI: Where might it replace PET/CT? J Magn Reson Imaging. 2017 11; 46(5):1247-1262.
Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439.
Lee HG, Park WJ, Shin SJ, Kwon SH, Cha SD, Seo YH, Jeong JH, Lee JY, Cho CH. Hsp90 inhibitor SY-016 induces G2/M arrest and apoptosis in paclitaxel-resistant human ovarian cancer cells. Oncol Lett. 2017 Apr; 13(4):2817-2822.
Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 03; 132(1):171-179.
Barajas RF, Krohn KA, Link JM, Hawkins RA, Clarke JL, Pampaloni MH, Cha S. Glioma FMISO PET/MR Imaging Concurrent with Antiangiogenic Therapy: Molecular Imaging as a Clinical Tool in the Burgeoning Era of Personalized Medicine. Biomedicines. 2016 Oct 31; 4(4).
Mabray MC, Cha S. Advanced MR Imaging Techniques in Daily Practice. Neuroimaging Clin N Am. 2016 Nov; 26(4):647-666.
Barajas RF, Cha S. Metastasis in Adult Brain Tumors. Neuroimaging Clin N Am. 2016 Nov; 26(4):601-620.
Nelson SJ, Li Y, Lupo JM, Olson M, Crane JC, Molinaro A, Roy R, Clarke J, Butowski N, Prados M, Cha S, Chang SM. Serial analysis of 3D H-1 MRSI for patients with newly diagnosed GBM treated with combination therapy that includes bevacizumab. J Neurooncol. 2016 10; 130(1):171-179.
Barajas RF, Butowski NA, Phillips JJ, Aghi MK, Berger MS, Chang SM, Cha S. The Development of Reduced Diffusion Following Bevacizumab Therapy Identifies Regions of Recurrent Disease in Patients with High-grade Glioma. Acad Radiol. 2016 09; 23(9):1073-82.
Cha SM, Shin HD, Ahn JS. Relationship of cubitus varus and ulnar varus deformity in supracondylar humeral fractures according to the age at injury. J Shoulder Elbow Surg. 2016 Feb; 25(2):289-96.
Cha SM, Shin HD, Ahn JS, Beom JW, Kim DY. Differences in the Postoperative Outcomes According to the Primary Treatment Options Chosen by Patients With Carpal Tunnel Syndrome: Conservative Versus Operative Treatment. Ann Plast Surg. 2016 Jan; 77(1):80-4.
Mabray MC, Cha S. CNS angiitis as a brain tumor mimic with a branching vascular abnormality on T2* MRI. Neurology. 2015 Nov 17; 85(20):1819-20.
Mabray MC, Cohen BA, Villanueva-Meyer JE, Valles FE, Barajas RF, Rubenstein JL, Cha S. Performance of Apparent Diffusion Coefficient Values and Conventional MRI Features in Differentiating Tumefactive Demyelinating Lesions From Primary Brain Neoplasms. AJR Am J Roentgenol. 2015 Nov; 205(5):1075-85.
Pastula DM, Burish M, Reis GF, Bollen A, Cha S, Ralph J, Douglas VC. Adult-onset central nervous system hemophagocytic lymphohistiocytosis: a case report. BMC Neurol. 2015 Oct 14; 15:203.
Ellingson BM, Bendszus M, Boxerman J, Barboriak D, Erickson BJ, Smits M, Nelson SJ, Gerstner E, Alexander B, Goldmacher G, Wick W, Vogelbaum M, Weller M, Galanis E, Kalpathy-Cramer J, Shankar L, Jacobs P, Pope WB, Yang D, Chung C, Knopp MV, Cha S, van den Bent MJ, Chang S, Yung WK, Cloughesy TF, Wen PY, Gilbert MR, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee. Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials. Neuro Oncol. 2015 Sep; 17(9):1188-98.
Villanueva-Meyer JE, Cha S. From Shades of Gray to Microbiologic Imaging: A Historical Review of Brain Abscess Imaging: RSNA Centennial Article. Radiographics. 2015 Sep-Oct; 35(5):1555-62.
Lupo JM, Molinaro AM, Essock-Burns E, Butowski N, Chang SM, Cha S, Nelson SJ. The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma. Neuro Oncol. 2016 Jan; 18(1):87-95.
Breshears JD, Rutkowski MJ, McDermott MW, Cha S, Tihan T, Theodosopoulos PV. Surgical Management of Intracranial Neuroenteric Cysts: The UCSF Experience. J Neurol Surg B Skull Base. 2015 Dec; 76(6):475-9.
Cha SM, Shin HD, Ahn JS, Noh CK. Temporary scaphocapitate fixation with or without radial shortening for adolescent Kienböck's disease. J Pediatr Orthop B. 2015 May; 24(3):207-14.
Mabray MC, Barajas RF, Cha S. Modern brain tumor imaging. Brain Tumor Res Treat. 2015 Apr; 3(1):8-23.
Horton JC, Douglas VC, Cha S. Reduced apparent diffusion coefficient in neuromyelitis optica-associated optic neuropathy. J Neuroophthalmol. 2015 Mar; 35(1):101-2.
Barajas RF, Pampaloni MH, Clarke JL, Seo Y, Savic D, Hawkins RA, Behr SC, Chang SM, Berger M, Dillon WP, Cha S. Assessing Biological Response to Bevacizumab Using 18F-Fluoromisonidazole PET/MR Imaging in a Patient with Recurrent Anaplastic Astrocytoma. Case Rep Radiol. 2015; 2015:731361.
Barajas RF, Cha S. Benefits of dynamic susceptibility-weighted contrast-enhanced perfusion MRI for glioma diagnosis and therapy. CNS Oncol. 2014 Nov; 3(6):407-19.
Ali S, Joseph NM, Perry A, Barajas RF, Cha S. Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant. J Neurooncol. 2014 Sep; 119(2):353-60.
Kim KC, Shin HD, Cha SM, Park JY. Comparisons of retear patterns for 3 arthroscopic rotator cuff repair methods. Am J Sports Med. 2014 Mar; 42(3):558-65.
Cha SM, Shin HD, Kim KC, Park IY. Outcomes of the mini-open Outerbridge-Kashiwagi procedure according to preoperative radiocapitellar joint status. J Hand Surg Am. 2014 Feb; 39(2):209-18.
Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS, Olshen AB, Cha S, Zhao Y, Moore RA, Mungall AJ, Jones SJM, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger MS, Chang SM, Taylor BS, Costello JF. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014 Jan 10; 343(6167):189-193.
Lee HJ, Han S, Kim YS, Nam JH, Kim HJ, Kim JW, Park W, Kim BG, Kim JH, Cha SD, Kim J, Lee KH, Yoon MS, Kim SM, Kim JY, Yoon WS, Lee NW, Choi JH, Park SY, Kim JY. Individualized prediction of overall survival after postoperative radiation therapy in patients with early-stage cervical cancer: a Korean Radiation Oncology Group study (KROG 13-03). Int J Radiat Oncol Biol Phys. 2013 Nov 15; 87(4):659-64.
Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41.
Cha SM, Shin HD, Kim KC, Song JH. Plating after tibial lengthening: unilateral monoaxial external fixator and locking plate. J Pediatr Orthop B. 2013 Nov; 22(6):571-6.
Rubenstein JL, Wong VS, Kadoch C, Gao HX, Barajas R, Chen L, Josephson SA, Scott B, Douglas V, Maiti M, Kaplan LD, Treseler PA, Cha S, Hwang JH, Cinque P, Cyster JG, Lowell C. CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma. Blood. 2013 Jun 06; 121(23):4740-8.
Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson SJ. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17.
Lupo JM, Essock-Burns E, Molinaro AM, Cha S, Chang SM, Butowski N, Nelson SJ. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9.
Essock-Burns E, Phillips JJ, Molinaro AM, Lupo JM, Cha S, Chang SM, Nelson SJ. Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging. 2013 Aug; 38(2):388-400.
Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51.
Jafri NF, Clarke JL, Weinberg V, Barani IJ, Cha S. Relationship of glioblastoma multiforme to the subventricular zone is associated with survival. Neuro Oncol. 2013 Jan; 15(1):91-6.
Bloch O, Han SJ, Cha S, Sun MZ, Aghi MK, McDermott MW, Berger MS, Parsa AT. Impact of extent of resection for recurrent glioblastoma on overall survival: clinical article. J Neurosurg. 2012 Dec; 117(6):1032-8.
Barajas RF, Phillips JJ, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang SM, Nelson SJ. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54.
Ozturk-Isik E, Pirzkall A, Lamborn KR, Cha S, Chang SM, Nelson SJ. Spatial characteristics of newly diagnosed grade 3 glioma assessed by magnetic resonance metabolic and diffusion tensor imaging. Transl Oncol. 2012 Feb; 5(1):10-8.
Elkhaled A, Jalbert LE, Phillips JJ, Yoshihara HAI, Parvataneni R, Srinivasan R, Bourne G, Berger MS, Chang SM, Cha S, Nelson SJ. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. Sci Transl Med. 2012 Jan 11; 4(116):116ra5.
Barajas RF, Cha S. Imaging diagnosis of brain metastasis. Prog Neurol Surg. 2012; 25:55-73.
Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL. Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res. 2012 Feb 15; 18(4):1146-55.
Barajas RF, Perry A, Sughrue M, Aghi M, Cha S. Intracranial subdural osteoma: a rare benign tumor that can be differentiated from other calcified intracranial lesions utilizing MR imaging. J Neuroradiol. 2012 Oct; 39(4):263-6.
Khayal IS, Vandenberg SR, Smith KJ, Cloyd CP, Chang SM, Cha S, Nelson SJ, McKnight TR. MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas. Neuro Oncol. 2011 Nov; 13(11):1192-201.
Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson SJ. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2011 May; 13(5):546-57.
Essock-Burns E, Lupo JM, Cha S, Polley MY, Butowski NA, Chang SM, Nelson SJ. Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2011 Jan; 13(1):119-31.
Srinivasan R, Phillips JJ, Vandenberg SR, Polley MY, Bourne G, Au A, Pirzkall A, Cha S, Chang SM, Nelson SJ. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM. Neuro Oncol. 2010 Nov; 12(11):1152-61.
Khayal IS, Polley MY, Jalbert L, Elkhaled A, Chang SM, Cha S, Butowski NA, Nelson SJ. Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme. Neuro Oncol. 2010 Sep; 12(9):908-16.
Barajas RF, Hodgson JG, Chang JS, Vandenberg SR, Yeh RF, Parsa AT, McDermott MW, Berger MS, Dillon WP, Cha S. Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging. Radiology. 2010 Feb; 254(2):564-76.
Bian W, Khayal IS, Lupo JM, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging. Transl Oncol. 2009 Dec; 2(4):271-80.
Pirzkall A, McGue C, Saraswathy S, Cha S, Liu R, Vandenberg S, Lamborn KR, Berger MS, Chang SM, Nelson SJ. Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2009 Dec; 11(6):842-52.
Kang C, Hwang DS, Cha SM. Acetabular labral tears in patients with sports injury. Clin Orthop Surg. 2009 Dec; 1(4):230-5.
Barajas RF, Chang JS, Segal MR, Parsa AT, McDermott MW, Berger MS, Cha S. Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. Radiology. 2009 Nov; 253(2):486-96.
Barajas RF, Collins DE, Cha S, Geschwind MD. Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody. Epilepsia. 2010 Mar; 51(3):473-7.
Cha S. Neuroimaging in neuro-oncology. Neurotherapeutics. 2009 Jul; 6(3):465-77.
Khayal IS, McKnight TR, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas. NMR Biomed. 2009 May; 22(4):449-55.
Chang SM, Nelson S, Vandenberg S, Cha S, Prados M, Butowski N, McDermott M, Parsa AT, Aghi M, Clarke J, Berger M. Integration of preoperative anatomic and metabolic physiologic imaging of newly diagnosed glioma. J Neurooncol. 2009 May; 92(3):401-15.
Crawford FW, Khayal IS, McGue C, Saraswathy S, Pirzkall A, Cha S, Lamborn KR, Chang SM, Berger MS, Nelson SJ. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. J Neurooncol. 2009 Feb; 91(3):337-51.
Saraswathy S, Crawford FW, Lamborn KR, Pirzkall A, Chang S, Cha S, Nelson SJ. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy. J Neurooncol. 2009 Jan; 91(1):69-81.
Aiken AH, Chang SM, Larson D, Butowski N, Cha S. Longitudinal magnetic resonance imaging features of glioblastoma multiforme treated with radiotherapy with or without brachytherapy. Int J Radiat Oncol Biol Phys. 2008 Dec 01; 72(5):1340-6.
Khayal IS, Crawford FW, Saraswathy S, Lamborn KR, Chang SM, Cha S, McKnight TR, Nelson SJ. Relationship between choline and apparent diffusion coefficient in patients with gliomas. J Magn Reson Imaging. 2008 Apr; 27(4):718-25.
Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, Tihan T, Vandenberg S, McDermott MW, Berger MS. Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas. J Clin Oncol. 2008 Mar 10; 26(8):1338-45.
Lim DA, Cha S, Mayo MC, Chen MH, Keles E, VandenBerg S, Berger MS. Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol. 2007 Oct; 9(4):424-9.
Osorio JA, Ozturk-Isik E, Xu D, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ. 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil. J Magn Reson Imaging. 2007 Jul; 26(1):23-30.
Ware ML, Hirose Y, Scheithauer BW, Yeh RF, Mayo MC, Smith JS, Chang S, Cha S, Tihan T, Feuerstein BG. Genetic aberrations in gliomatosis cerebri. Neurosurgery. 2007 Jan; 60(1):150-8; discussion 158.
Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH, Cha SY, Ryu JK, Choi YJ, Kim J, Fearon ER, Weiss SJ. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol. 2006 Dec; 8(12):1398-406.
Li Y, Osorio JA, Ozturk-Isik E, Chen AP, Xu D, Crane JC, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ. Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T. Magn Reson Imaging. 2006 Dec; 24(10):1295-302.
Lupo JM, Lee MC, Han ET, Cha S, Chang SM, Berger MS, Nelson SJ. Feasibility of dynamic susceptibility contrast perfusion MR imaging at 3T using a standard quadrature head coil and eight-channel phased-array coil with and without SENSE reconstruction. J Magn Reson Imaging. 2006 Sep; 24(3):520-9.
Ozturk-Isik E, Crane JC, Cha S, Chang SM, Berger MS, Nelson SJ. Unaliasing lipid contamination for MR spectroscopic imaging of gliomas at 3T using sensitivity encoding (SENSE). Magn Reson Med. 2006 May; 55(5):1164-9.
Smith JS, Lin H, Mayo MC, Bannerjee A, Gupta N, Perry V, Cha S. Diffusion-weighted MR imaging abnormalities in pediatric patients with surgically-treated intracranial mass lesions. J Neurooncol. 2006 Sep; 79(2):203-9.
Cha S. CNS tumors: monitoring therapeutic response and outcome prediction. Top Magn Reson Imaging. 2006 Apr; 17(2):63-8.
Lee MC, Cha S, Chang SM, Nelson SJ. Partial-volume model for determining white matter and gray matter cerebral blood volume for analysis of gliomas. J Magn Reson Imaging. 2006 Mar; 23(3):257-66.
Cha S. Dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in pediatric patients. Neuroimaging Clin N Am. 2006 Feb; 16(1):137-47, ix.
Sanchez-Mejia RO, Pham DN, Prados M, Tihan T, Cha S, El-Sayed I, McDermott MW. Management of a sporadic malignant subfrontal peripheral nerve sheath tumor. J Neurooncol. 2006 Jan; 76(2):165-9.
Waldron JS, Cha S. Radiographic features of intramedullary spinal cord tumors. Neurosurg Clin N Am. 2006 Jan; 17(1):13-9.
Smith JS, Cha S, Mayo MC, McDermott MW, Parsa AT, Chang SM, Dillon WP, Berger MS. Serial diffusion-weighted magnetic resonance imaging in cases of glioma: distinguishing tumor recurrence from postresection injury. J Neurosurg. 2005 Sep; 103(3):428-38.
Lee MC, Cha S, Chang SM, Nelson SJ. Dynamic susceptibility contrast perfusion imaging of radiation effects in normal-appearing brain tissue: changes in the first-pass and recirculation phases. J Magn Reson Imaging. 2005 Jun; 21(6):683-93.
Lupo JM, Cha S, Chang SM, Nelson SJ. Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol. 2005 Jun-Jul; 26(6):1446-54.
Oh J, Cha S, Aiken AH, Han ET, Crane JC, Stainsby JA, Wright GA, Dillon WP, Nelson SJ. Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edema. J Magn Reson Imaging. 2005 Jun; 21(6):701-8.
Laprie A, Pirzkall A, Haas-Kogan DA, Cha S, Banerjee A, Le TP, Lu Y, Nelson S, McKnight TR. Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2005 May 01; 62(1):20-31.
Cha S. Update on brain tumor imaging. Curr Neurol Neurosci Rep. 2005 May; 5(3):169-77.
Li X, Vigneron DB, Cha S, Graves EE, Crawford F, Chang SM, Nelson SJ. Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo. AJNR Am J Neuroradiol. 2005 Apr; 26(4):760-9.
Cha S, Tihan T, Crawford F, Fischbein NJ, Chang S, Bollen A, Nelson SJ, Prados M, Berger MS, Dillon WP. Differentiation of low-grade oligodendrogliomas from low-grade astrocytomas by using quantitative blood-volume measurements derived from dynamic susceptibility contrast-enhanced MR imaging. AJNR Am J Neuroradiol. 2005 Feb; 26(2):266-73.
Parney IF, Kunwar S, McDermott M, Berger M, Prados M, Cha S, Croteau D, Puri RK, Chang SM. Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma. J Neurosurg. 2005 Feb; 102(2):267-75.
Cha S. Perfusion MR imaging of brain tumors. Top Magn Reson Imaging. 2004 Oct; 15(5):279-89.
Ware ML, Cha S, Gupta N, Perry VL. Radiation-induced atypical meningioma with rapid growth in a 13-year-old girl. Case report. J Neurosurg. 2004 May; 100(5 Suppl Pediatrics):488-91.
Cha S. Perfusion MR imaging: basic principles and clinical applications. Magn Reson Imaging Clin N Am. 2003 Aug; 11(3):403-13.
Nelson SJ, Cha S. Imaging glioblastoma multiforme. Cancer J. 2003 Mar-Apr; 9(2):134-45.
Baek WK, Kim D, Jung N, Yi YW, Kim JM, Cha SD, Bae I, Cho CH. Increased expression of cyclin G1 in leiomyoma compared with normal myometrium. Am J Obstet Gynecol. 2003 Mar; 188(3):634-9.