UCSF - Department of Radiology & Biomedical Imaging

By type: FAIR - Grand Rounds - Progress in Radiology - CMFI - Other Seminar

By location: Parnassus - China Basin - Mission Bay - Mt Zion - SFGH - VAMC

Past Presentations

Date/Time	Presentation/Lecture	Type	Location
03 Sep,2004 11-12pm	PET Imaging of Locally Advanced Breast Cancer: Insights into Factors Affecting Response and Resistance to Systemic Therapy *David Mankoff, MD, PhD*	CBL/CMFI	CBL classroom
15 Sep,2004 2:30 pm	Anatomy Atlas of the Human Brain and its Registration to MRI, FMRI, and PET: Past, Present and Future *Ruzena Bajcsy, PhD* more...	CBL/CMFI	CBL classroom
28 Sep,2004 3:00-4:30pm	Review of basic statistics *Ying Lu, Ph.D.* Associate Professor in Radiology and Biostatistics more...	CBL/CMFI	CBL 331
12 Oct,2004 3:00-4:30pm	Review of linear models *Ying Lu, Ph.D.* Associate Professor in Radiology and Biostatistics more...	CBL/CMFI	CBL CBL 331
13 Oct,2004 12-1pm	CMFI Seminar Series: *Dr. Satoru Hayasaka* Introduction to Statistical non-Parametric Mapping for fMRI Data Analysis. *Dr. Mark Swanson* Combined Metabolic, Pathologic, and Genetic Analysis of Human Prostate Tissues: Quantitative Assessment of Histopathologic and mRNA Integrity After HR-MAS Spectroscopy.	CBL/CMFI	CBL 350
26 Oct,2004 3:00-4:30pm	Statistical methods for small samples *Mei-Hsiu Chen, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
03 Nov,2004 11am	Tissue sensing adaptive radar (TSAR) imaging for breast cancer detection *Elise Fear, Ph.D.*	CBL/CMFI	CBL classroom
08 Nov,2004 3:00-4:30pm	Discriminant analysis and classifications *John Kornak, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
10 Nov,2004 12-1pm	CMFI Seminar: An overview of American College of Radiology Imaging Network (ACRIN). Combined Metabolic, Pathologic, and Genetic Analysis of Human Prostate Tissues: Quantitative Assessment of Histopathologic and mRNA Integrity After HR-MAS Spectroscopy. *Mei-Hsiu Chen, PhD* *Mark Swanson, PhD*	CBL/CMFI	CBL classroom
18 Nov,2004 10am	Pyrimidine Analogs: Different Roles in PET Imaging *Sridhar Nimmagadda, PhD*	CBL/CMFI	CBL classroom
19 Nov,2004 12pm	Imaging the biology of the aging brain *Carolyn Meltzer, MD*	CBL/CMFI	CBL classroom
23 Nov,2004 3:00-4:30pm	Recursive partitioning data analysis *Ying Lu, Ph.D.* Associate Professor in Radiology and Biostatistics *Xiaojuan Li, Ph.D.* Assistant Researcher in Radiology more...	CBL/CMFI	CBL 331
07 Dec,2004 3:00-4:30pm	Longitudinal or correlated data and time series *John Kornak, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL Large Conference Room
08 Dec,2004 12-1pm	CMFI Seminar Series - TBD *TBD* CANCELED	CBL/CMFI	CBL classroom
04 Jan,2005 3:00-4:30pm	Survival analysis *Mei-Hsiu Chen, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
12 Jan,2005 12-1pm	DTI *Meredith Metcalf* DTI and Axonal Degeneration in Multiple Sclerosis *Roland Henry, PhD* DTI Fiber Tracking: Validation, Applications, and Predictability	CBL/CMFI	CBL classroom
12 Jan,2005 5:30 PM	State of the Department 5:15 PM - Refreshments *Ronald L. Arenson, MD* Professor and Chairman, Department of Radiology Contact: Katie.Murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
18 Jan,2005 3:00-4:30pm	Basic concepts for diagnostic tests *Mei-Hsiu Chen, Ph.D.* more... CANCELED	CBL/CMFI	CBL 331
27 Jan,2005 12:00-1:00 PM	FAIR - TBA	FAIR	Parnassus HSW-300
01 Feb,2005 3:00-4:30pm	Basic concepts for diagnostic tests *Mei-Hsiu Chen, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
09 Feb,2005 12-1pm	CMFI Seminar Series: *Olaf Saborowski, M.D.* MR Imaging of Inflammation and Tumors with folate receptor targeted contrast agents *Bill Barber* PSAPD's for SPECT: Position Sensitive Avalanche Photo Diode's for Single Photon Emission Computed Tomography	CBL/CMFI	CBL classroom
15 Feb,2005 3:00-4:30pm	Imaging in Clinical Trials Review of basic concepts of clinical trials, surrogate endpoints, role of imaging as a surrogate endpoints, quality control and quality assurance. *Ying Lu, Ph.D.* Associate Professor in Radiology and Biostatistics more...	CBL/CMFI	CBL 331
22 Feb,2005 12:00-1:00 PM	FAIR: Research in MR Imaging of Ischemic Heart Disease Lunch will be provided. *Charles Higgins, MD* *Maythem Saeed, PhD* *Oliver Weber, PhD* Contact: katie.murphy@radiology.ucsf.edu more...	FAIR	Parnassus HSW-300
23 Feb,2005 5:30 PM	Resident AFIP presentations Radiology Residents will be presenting cases from the Armed Forces Institute of Pathology in Washington D.C. (5:15 PM - Refreshments) *Department of Radiology: Radiology Residents* *Pathology Department: James P. Grenert, MD, PhD*	Grand Rounds	Parnassus N-217
01 Mar,2005 3:00-4:30pm	ROC analysis *Mei-Hsiu Chen, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
09 Mar,2005 12-1pm	CMFI Seminar Series *Peter Piels, Ph.D.* Analysis and improvement of quantification algorithms for magnetic resonance spectroscopy *Kayvan Keshari* The use of ex vivo HR-MAS NMR and in vivo MRI to characterize intervertebral disc degeneration	CBL/CMFI	CBL classroom
15 Mar,2005 3:00-4:30pm	The design clinical trials for evaluating imaging tools *Mei-Hsiu Chen, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
18 Mar,2005 12:30 to 2:30	Hemodynamics and Vascular Disease A bi-monthly seminar series with presentations by 3 or 4 speakers. (Click more.. link below for map). Contact: sandra.arrieta@radiology.ucsf.edu more...	Seminar	VAMC MRI Conference Room, Basement Bldg203
21 Mar,2005 2:00-3:00pm	Introduction to Entropy and Complexity Measures for Diagnostic Imaging This will be the first meeting of the Workgroup on Acquisition, Reconstruction and Processing (WARP. This talk will provide an introduction to the use of information theoretic measures such as entropy and statistical complexity for data analysis. Most of the talk will be concerned with providing some historical and mathematical background on why it is thought that these measures provide fundamental information on physical systems. If time permits some preliminary work on use of these measures for studying neurodegeneration via various MR imaging modalities will be discussed. *Karl Young* Contact: ashish@itsa.ucsf.edu	Seminar	VAMC 203 BA36
22 Mar,2005 12:00 - 1:00 PM	Breast Density *Jeffrey Tice, MD* "Breast Density as a Risk Factor for Breast Cancer" *John A. Shepherd, PhD* "New Technologies in Screening with Breast Density" *Catherine Klifa, PhD* "Breast Density Research Using Different Modalities (MRI and Optical Spectroscopy)" Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-300
23 Mar,2005 2:00PM	Improved Resolution for Low Resolution Magnetic Resonance Imaging Low-resolution MR modalities such as perfusion and MRSI are enhanced with prior information from segmented structural MRIs. An introduction to the methods involved will be given and the benefits of the approach will be demonstrated using simulated and real data. *John Kornak, PhD* Contact: kornak@radmail.ucsf.edu	Seminar	VAMC 203 BA36
24 Mar,2005 3:00 to 7:00 PM	Imaging Research Symposium Second Annual Symposium Times/Locations: Millberry Union - City Lights Rooms: 2:00-3:00 p.m. Poster Set-up Room S-214: 3:00-5:15 p.m. Oral Presentations Millberry Union Golden Gate and City Lights Rooms: 5:15-7:00 p.m. Poster Presentations & Reception	Seminar	Parnassus S-214
28 Mar,2005 12:00PM	Expanding the boundary of fMRI Xiaoping Hu, PhD., professor and Georgia Research Alliance Eminent Scholar in Imaging at Emory University, will be visiting the VA Medical Center Campus to deliver a seminar on fMRI. *Dr. Xiaoping Hu* Contact: ckramet@itsa.ucsf.edu	Seminar	VAMC 203 BA36
29 Mar,2005 3:00-4:30pm	Introduction to Bayesian Statistics *John Kornak, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
31 Mar,2005 12:00PM	Emerging Evidence of Chronic Brain Dysfunction in Some Gulf War-Associated Symptom Complexes Dr. Robert Haley, Chief of Epidemiology at the University of Texas Southwestern Medical Center at Dallas, will be visiting to discuss, "Emerging Evidence of Chronic Brain Dysfunction in Some Gulf War-Associated Symptom Complexes." *Dr. Robert Haley* Contact: ckramet@itsa.ucsf.edu	Seminar	VAMC NCIRE Conference Room (Building 14)
04 Apr,2005 11:00am to 12:00pm	VA Research Group Focus Group Seminar Norbert Schuff, PhD and Geon-Ho Jahng, PhD will be discussing their recent article, "Arterial sping labeling MRI--non invasive measurement of brain perfusion."	Seminar	VAMC 1A-122 (Building 200)
12 Apr,2005 3:00-4:30pm	Markov Chain Monte Carlo simulation Markov chain Monte Carlo (MCMC) is the computational tool that has enabled the widespread application of Bayesian statistics. The emphasis of the lecture will be on providing an intuitive understanding of how MCMC works and on how it can be employed within the package BUGS for general statistical problems. We will start by briefly reviewing the Bayesian statistical paradigm, then we will outline simple Monte Carlo methods before giving the full MCMC algorithm and discussion of how Markov chain Monte Carlo has enabled a multitude of possible inferences to be made from highly complex datasets, e.g. for images! *John Kornak, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
13 Apr,2005 12-1pm	CMFI Seminar Series - TBD *TBD*	CBL/CMFI	CBL classroom
18 Apr,2005 2:00pm-3:00pm	Phase Relationship Between Even and Odd Readout Echoes in EPSI In EPSI sequences, a train of echoes is acquired after each excitation using a periodically inverted readout gradient. In this echo train, odd and even echoes, acquired under positive and negative readout gradients, respectively, alternate. Because of the difference in gradient polarity, direct combination of data from even/odd echoes is known to produce artifacts. Therefore, these two echo series are usually processed separately, which implies certain disadvantages such as loss of half the spectral bandwidth. A number of methods were proposed to process or acquire EPSI data in such a way that information from odd and even echoes can be exploited to avoid such disadvantages. For example, with interlaced Fourier transform (processing), the full spectral bandwidth is maintained using a phase-sensitive algorithm to transform even and odd echo data directly. Also, the use of "blipped" phase-encoding gradients between even and odd readout echoes was proposed to effectively reduce the number of phase-encoding steps and thus reduce the minimum acquisition time. These approaches rely on a predictable phase relationship between even and odd readout echoes such that phase information can be extracted from or encoded in the data. In this talk, it will be demonstrated that due to B0 inhomogeneities (and possibly other causes) phase differences may occur between even and odd echoes that may interfere with these approaches. A method that can reduce such phase differences and its potential applications will be discussed. *Andreas Ebel, PhD* Contact: ashish@itsa.ucsf.edu	Seminar	VAMC BA36, Building 203
19 Apr,2005 11:00 AM	Interactive Visualization of Volumetric Image Data for Medical Education and Diagnosis View a novel intuitive user interface for manipulation of complex 3D / Volumetric Datasets: Applications include MDCT, MR, surgical planning & medical education *Michael Teistler, PhD* Agency for Science, Technology and Research (A*STAR), Singapore Winner of the highest award at InfoRad 2004 RSNA	Seminar	Parnassus S 322
19 Apr,2005 1:30 PM	Interactive Visualization of Volumetric Image Data for Medical Education and Diagnosis View a novel intuitive user interface for manipulation of complex 3D / Volumetric Datasets: Applications include MDCT, MR, surgical planning & medical education *Michael Teistler, PhD* Agency for Science, Technology and Research (A*STAR), Singapore Winner of the highest award at InfoRad 2004 RSNA	Seminar	CBL Conf. room
20 Apr,2005 5:30 PM	Residents Visiting Professor 5:15 PM - Refreshments *Mark W. Anderson, MD* Associate Professor of Radiology and Orthopaedic Surgery Division Head, Division of Musculoskeletal Radiology University of Virginia Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
20 Apr,2005 2:00pm to 3:00pm	"Deformation Morphometry" *Colin Studholme, PhD* Contact: jwigent@itsa.ucsf.edu	Seminar	VAMC BA36, Building 203
26 Apr,2005 3:00-4:30pm	Statistical Image Analysis *John Kornak, Ph.D.* Assistant Professor in Radiology more...	CBL/CMFI	CBL 331
03 May,2005 12:00 noon	Breast cancer screening and diagnosis using a pendant geometry dedicated CT system *John M. Boone, PhD* Professor of Radiology and Biomedical Engineering Vice Chairman of Radiology for Research University of California, Davis Sacramento, California Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
04 May,2005 5:30 PM	Howard Steinbach Memorial Lecture 5:15 PM - Refreshments *Barbara Weissman, MD* Chief, Musculoskeletal Radiology, Department of Radiology Brigham & Women's Hospital Boston, MA Contact: Katie.Murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
10 May,2005 3:00-4:30pm	Meta-analysis of imaging studies *Ying Lu, Ph.D.* Associate Professor in Radiology and Biostatistics more...	CBL/CMFI	CBL 331
14 Jun,2005 9-10 AM	Multimodality Breast Cancer Imaging Journal Club *Dipa Patel, MD (San Francisco General Hospital)* Topic: Digital Mammography Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL CMFI Classroom (China Basin Landing Lobby 7 3rd floor)
14 Jun,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *Colleen August Fordyce* General Pathology Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
28 Jun,2005 NOON	The Horizon of Functional Imaging: PET and PET-CT *Benjamin L. Franc, MD* Assistant Professor of Radiology UCSF School of Medicine Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-301
05 Jul,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *Martha Chase* Introduction to Cell Biology - This lecture will discuss cellular form and function with an emphasis on molecular imaging techniques used to understand cellular processes. In particular, we will highlight structural aspects of eukaryotic cells, ways that cells control their internal environment and respond to their external environment, and mechanisms controlling the fates of cells during development. To study these topics we will draw from knowledge gained using a variety of imaging methods including confocal microscopy, fluorescence resonance energy transfer (FRET), and calcium imaging. Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
12 Jul,2005 12-1 PM	Multimodality Breast Cancer Imaging Journal Club PET Instrumentation for Breast Cancer Imaging *Craig Levin, PhD* Molecular Imaging Program, Stanford University Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL CMFI Classroom (China Basin Landing Lobby 7 3rd floor)
13 Jul,2005 9:00 am	Atrial Fibrillation - new aspects in diagnosis and therapy *Friedhelm Saborowski, M.D.* Contact: saloner@itsa.ucsf.edu	Seminar	Parnassus M380
02 Aug,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *Matt Ludeman* Signal Transduction - Intra and extra- cellular signaling and cellular responses Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
09 Aug,2005 12-1 PM	Multimodality Breast Cancer Imaging Journal Club Screening with Breast Density *John Shepherd, PhD* UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL CMFI Classroom (China Basin Landing Lobby 7 3rd floor)
10 Aug,2005 11 AM	Peripheral Bone Densitometry: How if fits into the current Osteoporosis Diagnosis Paradigm Dr. John Shepherd hosts Jerry McLaughlin who will be joining us to talk about their new products as well as joint development projects between Compumed and UCSF. OsteoGram is a useful tool to diagnose osteoporosis and predict fracture risk. It requires no special training and has been cleared by the FDA for commercial use. The OsteoGram allows the entire process of assessing BMD to be performed at the point-of-care in less than five minutes. Once the required hand x-ray is taken, the developed film is scanned at the healthcare provider's facility with a standard desktop scanner, and the OsteoGram software analysis program instantly produces the BMD report. The new DICOM version of the OsteoGram automatically performs the analysis on digital (filmless) x-ray equipment or network servers, providing enhanced utilization of existing equipment. *Jerry McLaughlin, CEO of Compumed, Inc.* Contact: john.shepherd@radiology.ucsf.edu	CBL/CMFI	CBL CMFI Classroom (China Basin Landing Suite 350)
30 Aug,2005 Noon	Progress in Radiology Advanced MRI of Articular Cartilage *Garry Gold, MD* Assistant Professor of Radiology, Stanford University Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-301
31 Aug,2005 5:15 P.M.	Radiology Grand Rounds MRI of the Kidneys: Moving Beyond Anatomy to Function *Vivian Lee, MD, PhD, PhD from NYUMC* Professor of Radiology and Physiology and Neuroscience; Vice-Chair of Research Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
06 Sep,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *Susanna Mlynarczyk-Evans* DNA Replication, Transcription, and Translation -- In this high-level conceptual lecture, we will focus on the scale, forces, and structures in the macromolecular world; the flow of biological information between nucleic acid and protein languages and the roles of macromolecular machines in mediating this flow during the processes of replication, transcription, and translation. Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
09 Sep,2005 11:00 AM	How to Get More with Less: Model-Based MRI A classical problem in tomographic imaging is the so-called limited data reconstruction problem, which occurs when physical and temporal constraints prevent sufficient coverage of the data space. Traditionally, image reconstruction is performed using the well-known fast Fourier transform (FFT) algorithm, which often results in spurious ringing and loss of spatial/temporal resolution. With the rapid development of advanced computing technology, it has become possible to use non-FFT techniques for image reconstruction. In this talk, I will begin with a brief review of the diffraction-limited imaging problem in MRI and then discuss how prior or side information (e.g., data from different scans or from different receiver channels) can be effectively utilized to achieve high spatial and temporal resolution in various MRI applications. *Z.P. Liang* Contact: nschuff@itsa.ucsf.edu, ckramet@itsa.ucsf.edu	Seminar	VAMC Auditorium 7-112
13 Sep,2005 12-1 PM	Multimodality Breast Cancer Imaging Journal Club Monitoring therapeutic interventions with Diffuse Optical Spectroscopy: We've come a long way since the flashlights of the 1920's *Albert Cerussi, PhD* Laser Microbeam and Medical Program, Beckman Laser Institute, UC Irvine Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL China Basin Landing Lobby 7 3rd floor
23 Sep,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
27 Sep,2005 NOON	Advances in Neonatal Imaging *A. James Barkovich, MD* Professor of Radiology, Neurology and Neurosurgery Chief, Pediatric Neuroradiology UCSF Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
30 Sep,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
04 Oct,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *Mary Kate Alexander* Genetics / Molecular Biology Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
07 Oct,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
11 Oct,2005 12-1 PM	Multimodality Breast Cancer Imaging Journal Club Principles of Projection Imaging of the Breast *Robert Gould, Sc.D. (UCSF Department of Radiology)* Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL CMFI Classroom (China Basin Landing Suite 350)
14 Oct,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
19 Oct,2005 5:00 reception; 5:30 lecture	The Fourth Annual T. Hans Newton Lecture Spinal Cord Injury: Clinical, Imaging, and Surgical Considerations, and a Look to the Future *Robert M. Quencer, MD* Chairman and Chief of Radiological Services The Robert Shapiro MD Professor of Radiology Professor of Radiology, Neurological Surgery and Ophthalmology University of Miami Jackson Memorial Medical Center Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus HSW-301
21 Oct,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
25 Oct,2005 NOON	Cell labeling and in vivo tracking An update from the CMFI Contrast Agent Research Group *Heike Daldrup-Link, MD* Assistant Professor of Radiology and Pediatrics Department of Radiology Pediatric Radiology Section and Contrast Agent Research Group UCSF Medical Center University of California in San Francisco Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
28 Oct,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
04 Nov,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
08 Nov,2005 12-1 PM	Multimodality Breast Cancer Imaging Journal Club Study of Breast Tissue Composition using MRI and Diffuse Optical Spectroscopy *Catherine Klifa, PhD (Magnetic Resonance Science C* Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL CMFI Classroom (China Basin Landing Lobby 7 3rd floor)
08 Nov,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *John Shelton* Cell Biology and Cell Signaling in Cancer Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
11 Nov,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
14 Nov,2005 10 AM	Technology Development for MR Image Guided Interventions This seminar will include work on real-time imaging, devices and safety, imaging and assesment of ablations, as well as imaging the current distribution from RF ablation electrodes using MRI. *John Pauly* Contact: jacqueline.black@ucsf.edu	Seminar	VAMC Bldg. 203
16 Nov,2005 12:10	Common Disorders of Synovial Joints *Donald L. Resnick, MD* Professor of Radiology University of California, San Diego Chief, Osteoradiology Veterans Affairs Medical Center, San Diego Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
18 Nov,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
02 Dec,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
06 Dec,2005 10-11AM	Cell Biology for Nonbiologists Seminar Series *Paraic Kenny* Cancer Invasion and Metastases Contact: sue@mrsc.ucsf.edu	CBL/CMFI	CBL Classroom
09 Dec,2005 11-Noon	Statistical Methods for Improving the Analysis of Two-dimensional Difference Gel Electrophoresis and Phenotype Array Experiments *Dr. Imola Fodor* Biostatistics and Bioinformatics Group Lawrence Livermore National Laboratory Contact: ying.lu@radiology.ucsf.edu	Seminar	CBL CMFI Classroom (China Basin Landing Lobby 7 3rd floor)
09 Dec,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
16 Dec,2005 12-1:30 PM	General principles of CT and MR imaging Bioengineering 297 Advanced Musculoskeletal Imaging Seminar Meets every Friday Xiaojuan Li, Thomas Lang, Sharmila Majumdar *various* Contact: xiaojuan.li@radiology more...	CBL/CMFI	CBL large classroom
21 Dec,2005 10:00 AM	Workgroup on Acquisition, Reconstruction and Processing AN OVERVIEW OF GRAPH CUTS FOR VISION, GRAPHICS AND MEDICAL IMAGING I will give an overview of graph cut techniques, and describe a few of their applications. I will focus on the basic problem that graph cuts address, and describe both how graph cuts solves it and why it's such an important problem. Example applications will include: removing noise from a binary or gray-scale image; creating a realistic looking montage from a set of photographs; image segmentation; and parallel imaging reconstruction. This talk is intended to be self-contained, and to assume no prior knowledge of graph cuts. As a result, most technical details will be omitted. *Prof Ramin Zabih* from CompSci and Radiology, Cornell University Contact: ashish@itsa.ucsf.edu	Seminar	VAMC 203-BA36
19 Jan,2006 1:00 PM	WARP Seminar Intermolecular Multiple Quantum Coherence Imaging - Potential Applications for Mapping Neurodegeneration Abstract: A novel imaging method with contrast based on intermolecular multiple quantum coherence (iMQC) has recently been proposed for brain imaging. In a series of lectures, Andreas Ebel and I will review the basis of iQC and discuss potential applications for brain imaging. In the first lecture, I will present the theoretical principles of iMQC and an analysis of iMQC signal detection. *Norbert Schuff* Contact: ashish	Seminar	VAMC 200-3B130
31 Jan,2006	Monitoring the Evolution of Vascular Disease *David A. Saloner, PhD* Director, Vascular Imaging Research Center, VAMC Professor of Radiology University of California San Francisco Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
01 Feb,2006 5:15 PM	State of the Department *Ronald L. Arenson, MD* Chairman, Department of Radiology University of California San Francisco Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
14 Feb,2006 12:00 p.m. -1:00 p.m.	Introduction to Molecular Imaging with Nuclear Imaging Techniques Advanced Animal Imaging Seminar Series *Carina Mari Aparici, MD, PhD* (Nuclear Medicine Program, UCSF) Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
15 Feb,2006 5:15 PM	Resident AFIP Presentations UCSF Residents present cases from the Armed Forces Institute of Pathology *UCSF Residents*	Grand Rounds	Parnassus N-217
28 Feb,2006 5:15 PM	Earl Miller Lecture USPIOs: A New Paradigm for Lymph Node Imaging *Jelle Barentsz, MD* Professor of Radiology and Chair for Research Radiology Department University Medical Center Nijmegen, The Netherlands Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
14 Mar,2006 5:15 PM	Howard L. Steinbach Memorial Lecture Cervical Spine Trauma *Jeremy Kaye, MD* Professor and Vice-Chair, Department of Radiology Vanderbilt University Medical Center Contact: Katie Murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
14 Mar,2006 Noon-1pm	Magnetic Resonance Imaging of Small Animals Advanced Animal Imaging Seminar Series *Michael Wendland, PhD* (Earl Miller Radiologic Imaging Laboratory, UCSF) *Lisa Wilmes, PhD* (Magnetic Resonance Science Center, UCSF) Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
10 Apr,2006 NOON	Clinical Applications in Molecular Imaging: More Than What Meets The Eye� *King Li, MD* Chief, Radiology and Imaging Sciences Program Associate Director, Clinical Center National Institutes of Health Contact: katie.murphy@radiology.ucsf.edu	Seminar	Parnassus C-309
11 Apr,2006 12:00	�Biomedical imaging in the genomic era: opportunities and challenges� *King Li, MD* Director Candidate, Center for Molecular and Functional Imaging Contact: susan.sall@radiology.ucsf.edu	Seminar	CBL Classroom, 331
18 Apr,2006 Noon - 1:15pm	Principles, Developments, and Applications of small animal PET and CT imaging Advanced Animal Imaging Seminar Series *Patrick Phelps* Siemens Preclinical Solutions *Michael J. Paulus, PhD* Siemens Preclinical Solutions Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
20 Apr,2006 noon	CSF Biomarkers of Brain Tumors CMFI Monthly Seminar *James Ruberstein, M.D.,* Asst Professor In Residence, Hematology/Oncology Contact: susan.sall@radiology.ucsf.edu	CBL/CMFI	CBL Classroom, 331
25 Apr,2006 10:00 - 11:00 AM	MR-diffusion Study of Human Brain Tissue in vivo *Marzieh Nezamzadeh* Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Bldg 13 Conference Room
28 Apr,2006 NOON - lunch provided	"Imaging of Intracranial Aneurysms: Assessment, Artifacts, and Approaches" *Steven Hetts, MD* Clinical Fellow in Neuroradiology, UCSF *Alastair Martin, PhD* Associate Adjunct Professor of Radiology, UCSF *Sven Prevrhal, PhD* Assistant Adjunct Professor of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-300
16 May,2006 Noon - 1pm	Use of Small Animal Imaging to Study Breast Cancer and Metastasis Advanced Animal Imaging Seminar Series *Alana Welm, PhD* The G.W. Hooper Foundation, UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
17 May,2006 5:15 PM	Degenerative Disorders of the Vertebral Column Residents' Visiting Professor *Donald L. Resnick, MD* Professor of Radiology University of California, San Diego Chief, Osteoradiology Veterans Affairs Medical Center San Diego, CA Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
26 May,2006 NOON	Monitoring Progression and Early Detection of Alzheimer's Disease with MRI: The NIH Alzheimer's Disease Neuroimaging Initiative *Michael W. Weiner, MD* Director, Center for Imaging of Neurodegenerative Disease Veterans Affairs Medical Center Professor of Medicine, Radiology, Psychiatry, and Neurology, UCSF Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
13 Jun,2006 Noon-1pm	In Vivo Imaging with Quantum Dots Advanced Animal Imaging Seminar *Jianghong Rao, PhD* Molecular Imaging Program at Stanford (MIPS) Department of Radiology, Stanford University Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
27 Jun,2006 11:00AM-12:30PM	Diffusion MRI Methods for Neuronal Connectivity Mapping *Dr. Wang Zhan, Ph.D.* Research Staff Fellow National Institute on Drug Abuse Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Bldg 13 Conference Room
18 Jul,2006 Noon-1pm	High resolution ultrasound imaging of animals and drug delivery Advanced Animal Imaging Seminar Series *Katherine Ferrara, PhD* Professor of Biomedical Engineering, UC Davis Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
28 Jul,2006 12:45 - 6:00 PM	Third Annual Imaging Research Symposium: What's New in Radiology Research? UCSF Department of Radiology Contact: katie.murphy@radiology.ucsf.edu	Seminar	Parnassus Faculty Alumni House - 745 Parnassus Ave
08 Aug,2006 Noon-1pm	Small Animal Optical Imaging for Biomedical Research Advanced Animal Imaging Seminar Series *Ella F. Jones, PhD* Center for Molecular and Functional Imaging, UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
31 Aug,2006 NOON	7 TESLA HUMAN MRI AT UCSF: Initial Results and Future Directions *Daniel Vigneron, PhD* Professor of Radiology, UCSF *Doug Kelley, PhD* Scientist, GE Healthcare *Pratik Mukherjee, MD, PhD* Assistant Professor of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus N-217
11 Sep,2006 Noon-1pm	Better Imaging and Therapeutics Through Chelation Chemistry Advanced Animal Imaging Seminar Series *Martin Brechbiel, PhD* Chemistry Section, Center for Cancer Research, National Cancer Institute Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
12 Sep,2006 Noon-1PM	Non-invasive imaging of hypomorphic apolipoprotein E mice: A novel approach to investigate the molecular and cellular mechanisms responsible for the progression and regression of atherosclerosis Advanced Animal Imaging Seminar *Robert L. Raffai, PhD* Department of Surgery, UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
21 Sep,2006 12:00 p.m. to 1 p.m.	Breast MRI: An Overview for the Clinician Monthly UCSF Radiology Brownbag Lectures at Mt. Zion Medical Center *R. James Brenner, MD* Professor of Radiology, Chief, Breast Imaging Section Contact: lena.borodina@radiology.ucsf.edu	Seminar	MtZion B248, Herbst Hall
10 Oct,2006 Noon - 1pm	Dynamic imaging of leukocyte behavior in tumors and during acute inflammation in living mice using spinning disk confocal microscopy Advanced Animal Imaging Seminar Series *Mikala Egeblad, PhD* Department of Anatomy, UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
18 Oct,2006 5:00-Reception 5:30-Lecture	T. Hans Newton Annual Lecture "Acute Ischemic Stroke: Imaging Physiology and Guiding Therapy" *Ramon Gilberto Gonzalez, MD* Professor of Radiology, Harvard Medical School Chief of Neuroradiology, Massachusetts General Hospital, Boston, MA Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus C-701
24 Oct,2006 Noon-1pm	LARC/IACUC Town Hall at China Basin Part of Advanced Animal Imaging Seminar Series *Panels from LARC/IACUC* Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
14 Nov,2006 Noon-1PM	A Quantitative Approach to Molecular Imaging of Hypertrophic Cardiomyopathy Advanced Animal Imaging Seminar *Grant T. Gullberg, PhD* Center for Functional Imaging, Lawrence Berkeley National Laboratory Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
30 Nov,2006 12:00P.M	November CMFI Seminar *TRACY McKNIGHT, Ph.D.* MR Spectroscopy of Glial Brain Tumors *MARK SWANSON, Ph.D.* HR-MAS Spectroscopy of Post-radiation Biopsy Tissues	CBL/CMFI	CBL 331
12 Dec,2006 10:30 am	Interdisciplinary Forum on Cognitive Neuroscience and Neuroimaging Weekly Neuroscience Seminars held each Tuesday at 10:30 am. Please check website for further information and list of speakers. http://dnl.ucsf.edu/seminars/cogneuro.shtml Contact: mary.widmeyer@radiology.ucsf.edu more...	Seminar	Parnassus C-309
31 Jan,2007 5:15 PM	State of the Department *Ronald L. Arenson, MD* Chairman, Department of Radiology University of California, San Francisco Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
23 Feb,2007 12:15 PM	"Time of Flight" Imaging *William W. Moses, PhD* Senior Scientist Lawrence Berkeley National Laboratory, Berkeley, CA Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
28 Feb,2007 5:00 PM	Resident Armed Forces Institute of Pathology Presentations Featuring Senior Residents Department of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
12 Mar,2007 Noon-1pm	Small Animal PET Cellular and Molecular Imaging Seminar *Michael V. Green, Ph.D.* Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
22 Mar,2007 Noon-1pm	New technology for in vivo molecular imaging with PET Cellular and Molecular Imaging Seminar *Simon Cherry, Ph.D.* Professor of Biomedical Engineering (UC, Davis) Director, Center for Molecular and Genomic Imaging Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
27 Mar,2007 NOON	Fetal Ultrasound and MR Imaging *Vickie A. Feldstein, MD* Professor of Radiology, UCSF *Orit A. Glenn, MD* Assistant Professor of Radiology, UCSF *Bonnie N. Joe, MD, PhD* Assistant Professor of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-301
27 Mar,2007 Noon-1pm	Modeling cancer in the mouse: From genes to therapeutics Cellular and Molecular Imaging Seminar *Allan Balmain, PhD, FRSE* Barbara Bass Bakar Distinguished Professor of Cancer Genetics (Cancer Research Institute, UCSF) Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
28 Mar,2007 Noon-1pm	Molecular Imaging in Radiation Oncology and Radiobiology (In Vivo) Cellular and Molecular Imaging Seminar *Edward E. Graves, Ph.D.* Molecular Imaging Program at Stanford Department of Radiation Oncology Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
29 Mar,2007 5:00 PM	Analysis of Bone Tumors: Fundamental Concepts *Mark Kransdorf, MD* Mayo Clinic, Jacksonville, FL Contact: katie.murphy@radiology.ucsf.edu Download	Grand Rounds	Parnassus N-217
04 Apr,2007 5:15 PM	Growth and Use of Imaging Technologies in the US and the Impact on Radiation Doses to the Population Residents' Visiting Professor 2007 *Fred A. Mettler, MD* Fred A. Mettler Professor Emeritus, University of New Mexico, Albuquerque, NM Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus TOLAND HALL
08 May,2007 NOON	MRI-Guided Interventions Speaker #1: "Delivery of Cardiac Therapy"; Speaker #2: "Neurosurgical and Neuroradiological Applications of Interventional MR"; Speaker #3:"Body Applications and Steerable Catheters" *Maythem Saeed, PhD* Adjunct Professor of Radiology University of California, San Francisco *Alastair Martin, PhD* Associate Adjunct Professor of Radiology University of California, San Francisco *Mark W. Wilson, MD* Interim Chief, Radiology, SFGH Chief, Interventional Radiology, SFGH Associate Professor of Radiology University of California, San Francisco Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-300
08 May,2007 Noon-1PM	Quantitative Imaging in Small Animals Using SPECT-CT (In Vivo) Cellular and Molecular Imaging Seminar *Andrew Hwang, Ph.D.* Department of Radiation Oncology, UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
14 Jun,2007	256-CT Scanner: Clinical and Technical Experiences *Kazuhiro Katada, MD* Professor and Chairman Department of Radiology Fujita Health University Toyoake, Aichi, Japan Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus S-214
19 Jun,2007 Noon-1pm	High-resolution contrast-enhanced ultrasound: Potential for molecular imaging and drug development In Vivo Cellular and Molecular Imaging Seminar *Juergen Willmann, MD* Multimodality Molecular Imaging Laboratory Molecular Imaging Program at Stanford Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
27 Jun,2007 2:00 PM	MR Guided Precision Brain Access: Application to the Implantation of Deep Brain Stimulator Electrodes *Alastair J. Martin, Ph.D.* Associate Professor Department of Radiology University of California, San Francisco Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13
17 Jul,2007 10:30	Introduction to Nuclear Imaging Part of the Introduction to Imaging - Seminars for Summer Students Series All are welcome. *Youngho Seo, Ph.D.* Assistant Professor of Radiology Contact: sue@radiology.ucsf.edu	CBL/CMFI	CBL CBL Classroom
19 Jul,2007	Molecular Imaging in Cardiovascular Disease *Ella Fung Jones, PhD* Assistant Professor of Radiology *Carina Mari Aparici, MD, PhD* Assistant Professor of Radiology *Henry F. Van Brocklin, PhD* Professor of Radiology Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-302
24 Jul,2007 1:00	Computed Tomography - A Primer Part of the Introduction to Imaging - Seminars for Summer Students Series All are welcome. *Sven Prevrhal, Ph.D.* Contact: sue@radiology.ucsf.edu	CBL/CMFI	CBL CBL Classroom
25 Jul,2007 2:00 PM	Simulations of Magnetization Prepared MRI Experiments using Extended Phase Graph Theory When T1 and T2 relaxation times are known, MRI simulations provide a facile way to optimize sequence parameters for magnetization prepared experiments such as MP RAGE. The simulations also enable different variations of the sequence to be compared, and should prove very useful in incorporating acceleration factors into the experiment in an intelligent way. The Extended Phase Graph (EPG) will be introduced, and simulations based on the EPG for MP RAGE and several of its variations will be presented. *Gerald Matson, Ph.D.* *Lana Kaiser, Ph.D.* Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
08 Aug,2007 2-3:30PM	Future Directions for Brain Imaging of Neurodegenerative Disease: An Overview This talk will broadly review the general direction of the presenter's research as it evolved over the past 27 years, provide an update on highlights of new results obtained in the past year, and describe future plans for technique development, clinical studies, and SPECT scanning for amyloid during the coming year. *Michael W. Weiner, M.D.* Director, Center for Imaging of Neurodegenerative Disease Professor of Medicine, Radiology, Psychiatry, and Neurology University of California, San Francisco, U.S.A. Principal Investigator: Alzheimer's Disease Neuroimaging Initiative http://www.adni-info.org Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
22 Aug,2007 2-3:30PM	Proton MRS/MRSI of Mild Traumatic Brain Injury Dr. Andreas Ebel will review the background of mild traumatic brain injury (MTBI) and give and overview of previous work on MR spectroscopy and spectroscopic imaging in this area. *Andreas Ebel, Ph.D.* Center for Imaging of Neurodegenerative Diseases VA Medical Center San Francisco 4150 Clement Street (114M) San Francisco, CA 94121 phone: 415-221-4810 x 3599 fax: 415-668-2864 email: andreas.ebel@ucsf.edu Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
04 Sep,2007 Noon	Molecular Imaging using multimodality 4T MRI and Amyloid SPECT of Alzheimer's Disease In Vivo Cellular and Molecular Imaging Seminar Series *Michael W. Weiner MD* Director, Center for Imaging of Neurodegenerative Disease Contact: youngho.seo@radiology.ucsf.edu more...	CBL/CMFI	CBL Classroom
05 Sep,2007 2-3:30PM	Use of Real-Time MR Imaging for Brain Delivery of Viral Vectors and Nano-particles Success of gene therapy for neurological disorders depends on precise and reproducible intracranial delivery of viral vectors that encode therapeutic genes. However, optimal viral vector delivery into the brain is challenging and brain distribution of viral vectors is uncertain. We have demonstrated over the years that convection-enhanced delivery method (CED) is an efficient method for distribution of AAV 1 and 2 vectors in rats, monkeys and humans. Parameters required for optimal delivery such as volume, rate of infusion, and cannula placement had to be defined experimentally to predict desired coverage of the anatomical target, without introducing vector to regions outside the target including CSF. We developed an AAV delivery system that allows for direct monitoring of AAV distribution into the brain in real time. AAV1/GFP and AAV2/AADC vectors were co-administered with gadolinum-loaded nano-liposomes (GDL) and were delivered into the striatum, corona radiata and thalamus in 3 monkeys. Movement of GDL in the brain during CED can be monitored by MRI in real-time, thus we used GDL as surrogate marker for distribution of AAV1 and AAV 2 vectors. MRI-compatible guide cannules were placed over the target regions in each monkey and AAV vectors were infused in the MRI magnet with continuous acquisition T1 sequences. Volume of distribution (Vd) of GDL was evaluated using BrainLAB software directly from MRI and AADC gene expression was determined in vivo with PET using FMT tracer and post mortem using immuno staining. GFP expression was evaluated and quantified post-mortem as well. We found that Vd of AAV-mediated expression closely overlapped with Vd of GDL, regardless of the anatomical structure targeted and corresponded to FMT signal on PET. No adverse effects of AAV/GDL administration were detected in vivo and post-mortem. Image-guided delivery of AAV vectors is possible and will allow for efficient and safe gene transduction in the brain. Using this technology AAV delivery can be monitored in real-time during AAV administration, thus precise gene expression over small and larger targets can be assured without unnecessary introduction of the vector outside of the target region. Despite advances in cancer research, the clinical outcomes in children affected by a brain tumor is still dismal. Pediatric gliomas located in the brainstem urgently especially warrant new therapeutic approaches. As surgical removal is not an option due to the anatomic location of the neoplasm, we have focused on developing a minimally invasive drug-delivery method. Convection-enhanced delivery (CED) of nanoscale liposomes containing a chemotherapeutic agent has shown potential for the eradication of brain tumors in animal models. Single CED of the liposomal chemotherapeutic CPT-11 showed steady drug levels over 30 days in the CNS. CED bypasses the blood-brain-barrier, thereby allowing direct drug delivery without systemic side effects, along with metronomic chemotherapy. To evaluate this as an image-guided brain tumor treatment, we investigated the delivery, safety and efficacy of liposome-based nanoparticles containing gadolinium and CPT-11 following CED into spontaneous canine gliomas. In this veterinary trial, 4 canine patients with biopsy confirmed gliomas (1 astrocytoma III, 2 astrocytomas II, 1 oligodendroglioma) were infused with liposomes containing gadoteridol (1.85mM) and CPT-11 (48.2mg/ml). CED was monitored in real time by sequential MRI to assess localization and volume of distribution. Successful intratumoral delivery of nanoliposomal CPT-11 was demonstrated in all animals by MRI, although significant variability was observed and appeared related to catheter placement, rate of infusion, presence of necrosis and location in relation to ventricular and subarachnoid spaces. Infusions of up to 777 ul were feasible over 3.75 h using 1-3 catheters and infusion rates up to 4 ul/min. All infusions were limited by eventual leakage into ventricular or subarachnoid spaces within 3 h as captured by MRI. Efficacy of this treatment was clearly observed, with decreases in tumor volume of up to 80% on MRI; also, all dogs showed improvement in clinical signs following treatment. Anti-tumor effects appeared to correlate with MRI-based delineation of extent and localization of infusions. Host toxicity was minimal on serial neurological evaluations. Mild and transient CSF lymphocytic pleocytosis was documented following several of the infusions. Postmortem histopathologic analysis in 2 dogs was correlated with in-life MRI data. Significant differences were seen between infused and non-infused tumor tissue, including presence of frank tumor necrosis and histologic evidence of treatment effect in infused areas. No tissue injury was observed in surrounding normal brain. These studies indicate that MRI-guided CED infusion of liposome-based agents into spontaneous canine gliomas is feasible, well-tolerated and efficacious. The findings emphasize the role of MRI monitoring of therapeutic CED infusions to optimize delivery parameters. Because CED of liposomal CPT-11 has marked anti-tumor activity in canine spontaneous gliomas, we conclude that this approach warrants further investigation for the treatment of human brain tumors. The combination of our image-guided delivery method with nanoscale liposomal chemotherapeutics is a promising therapeutic, and an alternative to current therapeutic options. *Krystof Bankiewicz, M.D., Ph.D.* Professor Department of Neurosurgery, University of California San Francisco, Mission Center Building, Room 226,1855 Folsom St., San Francisco, California 94103, e-mail: Krystof.Bankiewicz@UCSF.edu Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
27 Sep,2007	Applications of Hyperpolarized C-13 Metabolic Imaging *Sarah J. Nelson, PhD* Professor of Radiology Director, Margaret Hart Surbeck Laboratory of Advanced Imaging Director, California Institute of Quantitative Biomedical Research Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-302
03 Oct,2007 2:00pm-3:30pm	Quantitative MR Imaging: an Approach to MS Genetics Multiple Sclerosis is a chronic immune-mediated disease affecting the central nervous system. Over time, several neurodegenerative characteristics can be appreciated and are likely responsible for progressive impairment seen in these patients. The contribution of genetics to MS susceptibility and severity is still under debate. Clinical markers of severity used in MS are not highly sensitive to change. The author will present the use of MR spectroscopic imaging data and volumetric determinants to better phenotype disease severity in MS as well as investigating genetic predictors of clinical outcome. *Dr. Daniel Pelletier* Assistant Professor of Neurology Department of Neurology University of California, San Francisco Dr. Pelletier is a clinician-scientist born and educated in the Province of Quebec, Canada. After first receiving a bachelor degree in Computer Sciences and studying a year in Artificial Intelligence at the University of Connecticut, Dr. Pelletier received his M.D. degree and completed his Neurology training in Quebec City at Laval University. He subsequently received research training in multiple sclerosis and advanced magnetic resonance imaging techniques at the Montreal Neurological Institute, Canada. He joined the University of California, San Francisco MS Center in 1999 as a clinical instructor and a recipient of a National Multiple Sclerosis Physician Award Grant for his work in molecular imaging. He received the Harry Weaver Neuroscientist Scholar Award in 2005 from the National Multiple Sclerosis Society for his research on magnetic resonance spectroscopy at high field strength. Dr. Pelletier receives extra-mural research funding from the National Multiple Sclerosis Society, National Institute of Health, and the Immune Tolerance Network. His work has recently been published in New England Journal of Medicine, Brain, Annals of Neurology, British Medical Journal, Neuroimage and Magnetic Resonance in Medicine. Contact: andreas.ebel@ucsf.edu	Seminar	VAMC Building 13 Conference Room
17 Oct,2007 2-3:30PM	Spatial HARDI: A New, Robust Approach to Diffusion Imaging High angular diffusion imaging (HARDI) has become very popular and important for probing the white matter connectivity structure of the human brain, and for assessing white matter health. Current HARDI methods are limited by high scan times, low SNR and low angular resolution. Recently, some model-based approaches for reconstruction of angular diffusion profiles have been proposed by Ress, Mukherjee et al using spherical harmonic decomposition. We have extended their method by applying spatial smoothness constraints in order to improve the noise tolerance and angular resolution of diffusion data with the same equipment and acquisition sequences. Several clinical and diagnostic applications can immediately benefit from this work, including better tractography, better detection of disease-related changes in white matter integrity, and improved resolution of tract imaging for surgical planning. Preliminary data indicate significant gains over current methods in terms of mean square error and fiber orientation accuracy. In this talk I will present a brief description of spatial constraints in diffusion imaging and show preliminary data. If time permits, I will discuss future planned work on better tractography, and some new ideas on obtaining connectivity matrices of the human brain (with some motivating examples). *Ashish Raj, Ph.D.* Center for Imaging of Neurodegenerative Diseases Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
17 Oct,2007 5:00 PM	T. Hans Newton Annual Lecture Functional MRI: Current and Future Applications *Jeffrey Petrella, MD* Associate Professor of Radiology Director, Alzheimer's Imaging Research Laboratory Duke University, Durham, SC Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
23 Oct,2007 NOON	RESIDENT AFIP PRESENTATIONS *Senior Residents* UCSF Department of Radiology Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus HSW-302
23 Oct,2007 Noon-1PM	Why is everyone so HYPED about HYPERpolarized MRI/MRS? In Vivo Molecular and Cellular Imaging Seminar *Mark Albers* UCSF/UCB Joint Graduate Group in Bioengineering Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
25 Oct,2007	BRAIN TRAUMA *Andreas Ebel PhD* "Spectroscopic Imaging of Mild Traumatic Brain Injury" *Pratik Mukherjee, MD, PhD* "Mapping Structural and Functional Connectivity in Traumatic Brain Injury witht DTI and MEG" *Geoff Manley, MD, PhD* "Traumatic Brain Injury: Meeting the Unmet Needs" Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-302
29 Oct,2007 12:45-1:45pm	Advanced MSK imaging seminar series -- Quantitative cartilage MRI and bone marrow MRSI *Xiaojuan Li, PhD* Contact: xiaojuan.li@radiology.ucsf.edu	Seminar	CBL Classroom 331
05 Nov,2007 12:45-1:45pm	Advanced MSK imaging seminar series -- Image Processing for MSK system *Julio Carballido-Gamio* Contact: xiaojuan.li@radiology.ucsf.edu	Seminar	CBL Classroom 331
07 Nov,2007 5:15 PM (snack) 5:30 (lecture)	Radiology Grand Rounds Molecular Imaging of Peritoneal Carcinomatosis *Peter Choyke, MD* Senior Clinician National Institutes of Health Bethesda, MD Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus S-214
14 Nov,2007 2-3:30PM	1H-MRS Measures of Brain Lactate Responses to Visual Stimulation: Application to Studies of Panic Disorder Lactate was previously viewed as a dead-end metabolite, produced in significant quantities only under hypoxic conditions. Recent studies have demonstrated a prominent metabolic role for lactate during periods of increased energy demand in brain and other tissues under fully aerobic conditions. Several groups (Prichard et al., 1991; Sappey-Marinier et al., 1992) used 1H-MRS to demonstrate reliable increases in visual cortex lactate during visual stimulation. Subsequently, other investigators argued that brain lactate responses could not be reliably detected with 1H-MRS (Boucard et al., 2004). Patients with Panic Disorder consistently demonstrate exaggerated lactate increases during various metabolic challenges. Measuring brain lactate during visual stimulation could test two competing theoretical models of this metabolic disturbance in Panic Disorder. We tested several 1H-MRS approaches to measuring brain lactate using a GE Signa 1.5 Tesla scanner. In two studies, we observed reliable brain lactate increases during visual stimulation using a 3 inch surface coil positioned under the occiput and TE = 288 msec. Suppression of lipid signal originating outside the voxel proved essential for accurate detection of lactate. We studied 15 Panic Disorder patients and 15 control subjects with this method and demonstrated significantly larger and more persistent lactate increases in the panic group. This finding argues against the hypothesis that panic patients have episodes of brain hypoxia and supports the view that they have a metabolic disturbance effecting the production or clearance of lactate. We recently implemented a lactate J-editing sequence and replicated our previous results with the TE=288 method. Increased lactate is detectable after 30 to 60 seconds of visual stimulation. Lactate increases an average of 23% over 4 minutes of stimulation, and returns to baseline about 6 minutes after the offset of visual stimulation. 1H-MRS can be used to study basic and clinical questions about brain lactate metabolism in man. *Richard Maddock, M.D.* Professor Department of Psychiatry and Behavioral Sciences and Imaging Research Center University of California, Davis 2230 Stockton Blvd. Sacramento, CA, 95817 phone: 916-734-3286 fax: 916-734-8750 Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
19 Nov,2007 12:45-1:45pm	Advanced MSK imaging seminar series -- Osteoarthritis - Insights from Imaging *David Hunter, MBBS, PhD* Contact: xiaojuan.li@radiology.ucsf.edu	Seminar	CBL Large Conference Room
28 Nov,2007 10-11AM	ELND005/AZD-103: A novel drug under study for Alzheimer�s Disease *Jesse Cedarbaum, M.D.* Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
28 Nov,2007 2-3:30PM	The Role of Signal Nonlinearity and Noise Level in Multimodal Characterization of Whiter Matter Degenerations White matter (WM) degeneration associated with aging, dementia, or vascular diseases have been investigated by MRI using either fluid attenuated inversion recovery (FLAIR) or diffusion tensor imaging (DTI), but the value of using both together characterizing WM lesions (WML) has not been thoroughly investigated. We have detected significant correlations between the FLAIR and DTI signals in WM regions where the lesion intensities are moderately high, but unfortunately, the correlation clusters were found shifting up to 12 mm away from the WML areas with the highest FLAIR intensities. Is this phenomenon just another effect of image misregistration? Or is it primarily due to more complicated mechanisms that we are not familiar with? Please join me to explore these questions ... *Wang Zhan, Ph.D.* Center for Imaging of Neurodegenerative Diseases San Francisco VA Medical Center Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
29 Nov,2007 3-4PM	Valproate Treatment for Dementia: A Case Study in Reverse Translational Research *Pierre Tariot, M.D.* Associate Director, Banner Alzheimer�s Institute Director, Memory Disorders Clinic at the Banner Alzheimer�s Institute Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
19 Dec,2007 Noon-1PM	Preclinical Molecular Imaging at UCLA Crump Institute In Vivo Cellular and Molecular Imaging Seminar Series *David Stout, Ph.D.* Co-Director, Small Animal Imaging Shared Resource Crump Institute for Molecular Imaging, UCLA Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
08 Jan,2008 Weekly 9-11AM	Course #170.03 Medical Imaging Informatics The Department of Radiology is offering again a 12 weeks course in novel concepts of medical imaging informatics in winter and spring semester 2008. The emphasis will be on image classification, registration, statistical processing, and data mining of multiparametric imaging data with specific emphasis on brain MRI. However, the techniques are general and applicable to a wide range of other medical imaging modalities. Two units credit can be earned for successfully attending the course. Course topics include: Dates Title 1/02 No Lecture Medical Imaging 1/08 1. Acquisition (uni/multimodal data) 1/15 2. Signal Estimation and Detection Image Processing 1/22 3. Rigid Image Registration 1/29 4. Non-rigid Registration/Atlas building 2/05 5. Segmentation 2/12 6. Spatial Connectivity Statistical Analysis 2/19 7. Data Visualization 2/26 8. Feature Extraction 3/04 9. Linear Modeling in Medical Imaging Data Mining 3/11 10. Principles of Data Mining 3/18 11. Multimodal Image Mining 3/25 12. Applications and Examples *Dr. Norbert Schuff* 415-221-4810 ext 4904 norbert.schuff@radiology.ucsf.edu *Dr. Karl Young* 415-221-4810 ext 3114 karl.young@radiology.ucsf.edu Contact: norbert.schuff@radiology.ucsf.edu	Seminar	Parnassus N-423
08 Jan,2008 9 am	MR Physics for Fellows and Residents: Neurorad Research Conference The Department is offering again advanced MR physics sessions as part of the annual MR physics course taught and organized by Dr. Dieter J. Meyerhoff, CIND, tel. 221-4810 x4803. Individual sessions are scheduled Tuesdays as follows: � Dec 04, 07: Dr. Andreas Ebel Fast Imaging: Fast Spin Echo, Gradient-Recalled Echo, EPI etc. � Jan 08, 08: Dr. Mark Swanson Clinical MRS: Low- and high-field - cancelled!!!! � Jan 22, 08: Dr. Roland Henry Diffusion MRI: Primarily methods � Jan 29, 08: Dr. Pratik Mukherjee Diffusion MRI: Primarily clinical � Feb 05, 08: Dr. David Saloner Flow/MRA � Feb 12, 08: Dr. Norbert Schuff Perfusion MRI: Methods and clinical � Feb 26, 08: Dr. Linda Chao Functional MRI � March 04, 08: Dr. Sue Noworolski MR hardware and coils � March 11, 08: Dr. Mark Swanson Clinical MRS: Low- and high-field (re-scheduled from Jan 8) Contact: Dieter.Meyerhoff@ucsf.edu	Seminar	Parnassus M-380
11 Jan,2008 Noon-1pm	Magnetic resonance imaging of Intracerebral Glioma Xenografts and Apolipoprotein AI metabolism In Vivo Cellular and Molecular Imaging Seminar *Dr. Renuka Sriram* University of California, Davis Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Classroom
24 Jan,2008 NOON	NON-CANCER SPECTROSCOPY "Non-Neoplstic Applications of Proton MR Spectroscopy in Pediatric Brain Disease" A. James Barkovich, MD "Neuro MR Spectroscopy in Alcoholism" Dieter J. Meyerhoff, PhD "MR-Spectrocscopic Imaging in Epilepsy" Susanne G. Mueller, MD *A. James Barkovich, MD* Professor in Residence Department of Radiology, UCSF *Dieter J. Meyerhoff, PhD* Professor in Residence Department of Radiology, UCSF *Susanne G. Mueller, MD* Assistant Adjunct Professor Department of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus N-225
27 Feb,2008 5:15-refreshments 5:30-lecture	State of the Department *Ronald L. Arenson, MD* Chairman, Department of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
28 Feb,2008	The Radiology Operations Strategic Dashboard Discuss a strategic radiology quality and key performance indicator framework. Understand the role of organizational alignment with strategic dashboarding. Discuss the role of dashboarding for measuring quality and continuous quality improvement. *Paul G. Nagy, PhD* Paul Nagy, PhD Director, Quality and Informatics Research Associate Professor of Radiology University of Maryland School of Medicine Baltimore, MD Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus Toland Hall
06 Mar,2008 10:00 AM	Wavelet-Based Image Analysis The continuous wavelet-transform acts as a mathematical microscope to characterize spatial image information over a continuous range of size scales. The so-called Wavelet Transform Modulus Maxima (WTMM) method is a multifractal formalism that has been used to characterize the turbulent nature of Earth clouds, to quantify the anisotropic structure of hydrogen gas in the Galactic disk, to detect microcalcification clusters in human breast tissue, to quantify the soft-tissue in-growth into artificial porous bone implants, and to objectively characterize the morphology and position of chromosome territories in the cell nucleus. After reviewing past and current applications of the WTMM method, a potential application to brain tissue imaging will be presented. *Andre Khalil, Ph.D.* Assistant Professor Department of Mathematics University of Maine, Orono, ME Adjunct Research Scientist The Jackson Laboratory Bar Harbor, ME Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
06 Mar,2008	Applications of Hyperpolarized C-13 Metabolic Imaging *Sarah J. Nelson, PhD* Director, Margaret Hart Surbeck Laboratory of Advanced Imaging Scientific Director, California Institute of Quantitative Biomedical Research (QB3) Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-301
13 Mar,2008 Noon-1PM	Transgenic Approaches to Understanding Alloimmunity Cellular and Molecular Imaging Seminar Series *Sang-Mo Kang, MD* Department of Surgery, UCSF Contact: youngho.seo@radiology.ucsf.edu	CBL/CMFI	CBL Large Conf. Room
13 Mar,2008 4-5PM	Reduced Distortion and Susceptibility Artifacts in ASL Imaging with 3D GRASE ASL imaging with 2D EPI or 3D GRASE have distortions and susceptibility artifacts effected by the echo train length. A novel 3D GRASE k-space trajectory utilizing shorter echo trains interleaved in k-space has resulted in marked reduction in distortions and artifacts in 3D ASL images and improved slice coverage in outer volume regions. Results at 1.5T and 4.0T in human brain are presented. *David Feinberg, MD, PhD* Advanced MRI Technologies, Sebastopol, CA *Sudhir Ramanna* Advanced MRI Technologies, Sebastopol, CA Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
19 Mar,2008 2-3:30PM	MR Spectroscopy of Amino Acids in the Human Brain: Development of New Methods for Higher Magnetic Fields The presentation will focus on developing MR methods for observation of the glutathione (GSH) and -amino butyric acid (GABA) in vivo. GSH is a powerful antioxidant found in the central nervous system (CNS), as well as in other kinds of cells. GABA is major inhibitory neurotransmitter in the CNS. MR Spectroscopy (MRS) has been long established as a valuable tool for non-invasive detection of various amino acids in the human brain, including GSH and GABA. However, the detection of these compounds is hindered by low concentration and spectral overlap with other metabolites. The increasing availability of higher field MR instruments opens up a range of new approaches for detection of these amino acids in vivo. The first part of the seminar will describe the development of new approaches for high field MRS. This strategy combines sophisticated numerical simulations that closely mimic experimental conditions with advanced data processing techniques. The generation of accurate prior knowledge using numerical simulations facilitates the optimum data acquisition and processing routines for clinical studies, tailored to particular field strength. The second part of the seminar will show the results of application of numerical simulations to the detection of GSH and GABA at 4 Tesla. A decrease in GSH concentrations has been implicated in the pathogenesis of several diseases, including Amyotrophic Lateral Sclerosis, AIDS, Alzheimer�s disease and Parkinson disease, while GABA alterations are also implicated in several neurological and psychiatric disorders. *Lana Kaiser, Ph.D.* Associate Research Scientist Center for Imaging of Neurodegenerative Diseases Contact: natalie.bareis@ucsf.edu	Seminar	VAMC CIND Building 13 Conference room
01 Apr,2008 NOON	Advances in Forensic Radiology Earl Miller Memorial Lecture *Barry D. Daly, MD, FRCR* Professor of Radiology Chief of Abdominal Imaging and Vice-Chair, Research Department of Radiology University of Maryland Medical Center Baltimore MD Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus HSW-303
02 Apr,2008 2-3:30PM	Body mass index and MR markers of brain integrity - implications for aging and dementia In this seminar I will review and discuss the associations between volumetric and spectroscopic markers and BMI in otherwise-healthy and alcohol dependent populations. Additionally, I will discuss possible extensions of this study using data obtained at CIND. *Stefan Gazdzinski, Ph.D.* Center for Imaging of Neurodegenerative Diseases San Francisco VA Medical Center Contact: natalie.bareis@ucsf.edu	Seminar	VAMC CIND Building 13 Conference room
07 Apr,2008 5:15 (refresh) 5:30 PM lecture	Issues in Imaging in Pediatric Obesity Residents' Visiting Professor 2008 *Lane F. Donnelly, MD* Professor of Radiology and Pediatrics Director, Radiologist-in-Chief Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati, OH Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus C-701
16 Apr,2008 2-3:30PM	Advanced MRI and MRSI of cartilage and bone marrow -- with a focus on osteoarthritis Abstract: Osteoarthritis affects more than 20 millions Americans and is second only to cardiovascular disease as a top contributor to chronic disability. Despite of its prevalence, early diagnosis of osteoarthritis remains a challenge. MR imaging of cartilage has improved greatly during the past decade. Cartilage morphology can be examined, and cartilage volume and thickness can be quantified using very high-resolution MR images. The most active development in this field, however, lies in imaging cartilage matrix biochemistry. We have developed a novel MRI technique, referred as T1rho (spin-lattice relaxation in the rotating frame) imaging, that can probe cartilage biochemical changes at the very early stages of the disease. We showed that T1rho values were elevated significantly in osteoarthritic cartilage, and negatively correlated with glycosaminogycan concentration in cartilage. Furthermore, pathologies in subchondral bone and bone marrow may play important roles during osteoarthritis progression. We have applied advanced MR spectroscopic imaging techniques to quantify water and lipids changes in bone marrow, and have evaluated the relationship between bone/bone marrow changes and cartilage damage in osteoarthritic and acutely injured knees. Currently we are focused on the knee joint. The techniques will be extended to evaluate other joints such as hip and other problems such as low back pain. *Xiaojuan Li, Ph.D.* Assistant Professor of Radiology, UCSF Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
30 Apr,2008 5:15 (refresh) 5:30 PM lecture	MRI of Rotator Cuff and Impingement Syndromes: New Persectives Howard L. Steinbach Memorial Lecture *Javier Beltran, MD* Chairman Department of Radiology Maimonides Medical Center Brooklyn NY Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-225
30 Apr,2008 2-3:30PM	Deformation Morphometry and Clinical Applications Computational shape analysis of structural MRI data that identifies anatomical changes in the brain has the potential to identify patterns of atrophy due to normal aging or disease, and identify how different clinical or cognitive testing variables are related to specific brain structures. Nonlinear, nonrigid image registration techniques have been widely used to warp the 3D MRI of one brain into the space of a reference brain or atlas while accounting for the anatomical variations between them. This approach has been also been used to measure the longitudinal change between sequential MRIs of the same subject. Deformation morphometry is a method for analyzing and quantifying the relationship between brain anatomy and disease or function, typically by computing statistics voxel-by-voxel using three-dimensional (3D) maps of local anatomical size derived from nonrigid image registration methods. In this talk, an overview of deformation morphometry methodology will be presented, as well as numerous examples using deformation morphometry to study clinical populations. *Valerie Cardenas-Nicolson, Ph.D.* Assistant Adjunct Professor, UCSF Center for Imaging of Neurodegenerative Diseases, SFVAMC Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
14 May,2008 2-3:30PM	MEG imaging of dynamic cortical-cortical interactions: developing brain biomarkers of cognitive function in health and disease Functional imaging studies with PET and fMRI have clearly demonstrated that multiple cortical regions are involved in cognitive operations, and growing evidence supports the notion that these cortical regions may be functionally interactive during cognition. MEG/EEG provides cortical electrophysiological measures with millisecond temporal resolution that makes it possible to investigate the interactions of cortical regions on a timescale commensurate with sub-second cognitive processes. In addition, MEG/EEG can measure oscillatory activity in different frequency bands associate with different cortical functions. These oscillatory bands therefore provide functional tags for cortical activity. I will discuss new MEG/EEG cortical imaging capabilities for: (1) imaging cortical activity in space, time and frequency; (2) investigating the sub-second dynamics of cortical-cortical interactions in different frequencies; (3) using Granger Causality measures of directional influences to investigate basic concepts of functional organization such as top-down versus bottom-up interactions in cortical networks; (4) deriving within-subject statistics for these measures, which enables studies of individual differences, effects of experience and training within individual subjects, and a wide range of clinical applications. I will provide examples of these capabilities from studies of visual and auditory attention. A major theme of this talk and discussion will be to illustrate how our results support the development of new biomarkers for cognition in health and disease. *Greg Simpson, Ph.D.* Director, Dynamic Neuroimaging Laboratory UCSF Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
22 May,2008	MS: Towards Mechanisms and Pathogenesis *Roland Henry, PhD* "Atrophy and Wallerian Degeneration in MS" Associate Professor in Residence UCSF Advanced Imaging in MS (AIMS) Group Department of Radiology and Biomedical Imaging Graduate Group in Bioengineering, UC San Francisco & Berkeley *Radhika Srinivasan, PhD* "MR Spectroscopy in MS: Biomarkers for Mechanisms of Neurodegeneration" Assistant Research Specialist UCSF Advanced Imaging in MS (AIMS) Group Department of Radiology and Biomedical Imaging *Daniel Pelletier, MD* "Genetics and Imaging in MS" Associate Professor in Residence, Department of Neurology UCSF Advanced Imaging in MS (AIMS) Group Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus N-217
10 Jun,2008 NOON	Applications of 3-D Image Processing in Diagnosis, Patient Management and Education The Presentation will include a Demonstration of Stereoscopic 3-D (complete with 3-D Glasses!) *Richard S. Breiman* Clinical Professor of Radiology Director, Henry I. Goldberg Center for Advanced Imaging Education Departmentof Radiology, UCSF *Jeremy Durack, MD* Clinical Fellow Interventional Radiology Section Department of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-300
18 Sep,2008	Fifth Annual Research Symposium Department of Radiology and Biomedical Imaging, UCSF Contact: katie.murphy@radiology.ucsf.edu	Seminar	Parnassus Millberry Union Golden Gate Rm
09 Oct,2008 NOON	Body Perfusion/Permeability Featuring Department of Radiology and Biomedical Imaging Speakers *Ka-Loh Li, PhD* "Predicting Disease Recurrence in Breast Cancer by Using High-Spatial-Resolution Signal Enhancement Ration (SER) Imaging" Ka-Loh Li, PhD Assistant Research Scientist *Susan Noworolski, PhD* "Dynamic Contrast Enhanced MRI of the Prostate" Susan Noworolski, PhD Assistant Adjunct Professor *Yanjun Fu, PhD, and Benjamin Yeh, MD* "Dynamic Contrast-Enhanced CT and MR Imaging in the Abdomen" Yanjun Fu, PhD, and Benjamin Yeh, MD Associate Professor in Residence and Yanjun Fu, PhD Assistant Research Scientist Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-301
22 Oct,2008	Diagnostic Injections in Spinal Disorder T. Hans Newton Annual Lecture *Eugene J. Carragee, MD* Professor and Vice-Chairman Department of Orthopaedic Surgery Chief, Division of Spine Surgery Stanford University Contact: Katie.Murphy@radiology.ucsf.edu	Grand Rounds	Parnassus HSW-301
04 Nov,2008 3:00 PM	Multiparametric ASL Perfusion Acquisition and Analysis Arterial Spin Labeling (ASL) techniques offer a possibility to assess brain perfusion. Common protocols rely on measuring the longitudinal magnetization of labeled blood at one time point after the labeling pulse has been applied. However, precise perfusion measurements require full knowledge of the temporal evolution of the ASL signal. In addition, T2 relaxation of the ASL signal has generally been ignored. *Johannes Gregori* Center for Imaging of Neurodegenerative Diseases Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
12 Nov,2008 2-3:30PM	Internalizing antibodies for targeted cancer imaging and therapy Enhancing the discrimination between tumor and host has been an underlying goal of efforts to improve the diagnosis and treatment of cancer. Over the past decades considerable interest has focused upon targeting systems designed to permit selective delivery of a variety of agents, including drugs, radioisotopes and toxins, to tumor cells, for both diagnosis and therapy. A vast body of information has accumulated on this subject, and considerable emphasis has been placed on the use of antibodies as carriers. Due to ease of accessibility, tumor cell surface antigens are invaluable targets for imaging and therapeutic developments, the internalizing tumor epitopes could be exploited to achieve efficient and specific intracellular delivery of radionuclide for imaging and radiotherapy or chemotherapeutic drugs or other tumor-modulating agents. A panel of phage antibodies has been generated by selection of phage antibody display libraries against tumor cells in situ on both fresh frozen and paraffin-embedded tissues using laser capture micro-dissection. The ability to recognize tumor cells in situ and to internalize makes these antibodies attractive candidates for the development of targeted cancer imaging and therapeutics. *Jiang He, Ph.D.* Assistant Professor Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco Contact: natalie.bareis@ucsf.edu	Seminar	VAMC CIND Building 13 Conference room
19 Nov,2008 2:00 PM	RF transceiver development for facilitating high and ultrahigh field MR and parallel imaging in humans High (3 and 4T) and ultrahigh magnetic fields (7, 8 and 9.4T) for human MR applications have been advocated due to their intrinsically high signal-to-noise ratio (SNR) and spectral dispersion. A major challenge to fully realize such high-field advantages is the design of high-frequency RF coils, especially large volume coils and parallel imaging coil arrays, which determines the feasibility of in vivo MR studies at ultra-high fields. The technical difficulties are more pronounced in designing transceiver arrays which have become a popular solution to issues on SAR, B1 shimming and B1+ efficiency at high field strengths. In this talk, I will discuss the problems faced in high frequency coil designs, such as increased �radiation� losses, degraded sensitivity, image inhomogeneity, complex wave behaviors, high operating frequency limitations, decoupling difficulties, and also the solutions using the microstrip transmission line (MTL) design method and other new technologies developed in our lab. The coil design examples covering from surface coils and volume coils to parallel imaging arrays will be also discussed. *Dr. Xiaoliang Zhang* Associate Professor Department of Radiology and Biomedical Imaging University of California, San Francisco Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
15 Dec,2008 8:30 am - 5 pm	2008 UCSF Cancer Imaging Retreat Imaging Cancer: From Cell to Man *Hosted by:* the Helen Diller Family Comprehensive Cancer Center, the Department of Radiology & Biomedical Imaging, and the California Institute for Quantitative Biosciences *Organizing Committee:* Sarah Nelson, PhD; Sabrina Ronen, PhD; Margaret Tempero, MD Registration open to all UCSF Faculty, Students, and Staff as well as Entrepreneurs and Industry. Contact: idonnah.hipolito@radiology.ucsf.edu	Seminar	Mission Genentech Auditorium
16 Dec,2008 3:30PM	Model selection for proportional hazards models with mixed effects We will discuss estimation and model selection under the proportional hazards mixed effects model (PHMM). Unbiased estimates of the Akaike information by a profile Akaike information criterion (pAIC) can be used for model selection under PHMM. The pAIC focuses on the population parameters, such as the fixed effects and variance components (similar to AIC for linear and generalized linear mixed models). We will also discuss conditional AIC (cAIC), which, in turn, incorporates the estimated random effects. Computation of both pAIC and cAIC under PHMM will be addressed, and examples will be given to show their applications. *Dr. Michael Donohue* Assistant Project Scientist Division of Biostatistics and Bioinformatics University of California, San Diego Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
06 Jan,2009 Tuesdays, 9-11AM	Course #170.03 Medical Imaging Informatics Synopsis: We are offering a 12 weeks course on medical imaging informatics as a resource for students who are new to imaging informatics as well as for professionals who want to become more familiar with state-of-the-art concepts in this field. During the course students will be introduced to the basic concepts of imaging informatics, information theory and to modern strategies in image processing, image statistical analysis, and data mining. Though many examples in this course will apply to MRI, the presented strategies are general and apply to a wide range of other medical imaging modalities, such as CT, SPECT and PET. Two units credit can be earned for students successfully attending the course. The entire course consists of four modules, as listed below: I. Basics: This segment of the course will provide an overview of medical imaging modalities, complexity of image interpretation, foundations of imaging informatics and concepts of information theory, including definitions of entropy, complexity, probability. II. Image Processing Techniques: This segment will introduce general algorithms for rigid and non-rigid image registrations, the concept of atlas building, image segmentation, and new trends in computational anatomy. III. Statistical Analysis: This segment will present basic statistical concepts for image analysis, including linear modeling, multivariate analysis, feature extraction techniques, including principle components analysis, independent components analysis, and active shape models. IV. Data Mining: This segment will introduce basic concepts of data mining for uni- and multimodal imaging applications. Different mining algorithms will be discussed, including decision trees, neural nets, Bayesian classifiers, support vector machines, non-parametric and reinforcement learning. *Norbert Schuff, Ph.D.* Physicist & Professor of Radiology Center for Imaging of Neurodegenerative Diseases Veterans Affairs Medical Center Department of Radiology and Biomedical Imaging University of California, San Francisco *Karl Young, Ph.D.* Center for Imaging of Neurodegenerative Diseases Veterans Affairs Medical Center University of California, San Francisco Contact: norbert.schuff@ucsf.edu	Seminar	Parnassus U70.15
12 Jan,2009	Rapid Magnetic Resonance Imaging of Coronary Artery Disease *Craig Meyer, PhD* Associate Professor of Biomedical Engineering and Radiology, University of Virginia Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus S-214 (Med Sciences Bldg)
20 Jan,2009 NOON	Cardiac MR Perfusion and Oxygenation Imaging: From Qualitative to Quantitative Assessment *Jie Zheng, PhD* Assistant Professor of Radiology Washington University Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus C-701
28 Jan,2009 1 - 2 p.m.	Multi-Scale Bone Quality Assessment: High-Resolution Structural and Compositional Imaging Bone quality assessment at the level of tissue micro-structure and composition is essential to understanding mineralization mechanisms and skeletal mechanics in normal growth and development as well as in osteoporosis and other disease states. Dr. Kazakia's talk will focus on: (1) technology development in the area of high-resolution structural and compositional imaging; and (2) the application of these imaging technologies to emerging clinically-oriented musculoskeletal research questions. *Galateia J. Kazakia, Ph.D.* Contact: jeffery.kennedy@radiology.ucsf.edu	CBL/CMFI	CBL 331
30 Jan,2009 NOON	4D Flow and Plaque MRI in the Aorta: New Insights in the Vascular Origin of Stroke *Michael Markl, PhD* Research Associate Medical Physics Department of Diagnostic Radiology University Hospital Freiburg Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-301
10 Feb,2009	STATE OF THE DEPARTMENT *Ronald L. Arenson, MD* Alexander R. Margulis Distinguished Professor and Chairman, Department of Radiology, UCSF Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-225
12 Feb,2009 NOON-sandwiches for attendees	Utilizing Preclinical Imaging for Biomedical Research at UCSF: PET/CT, SPECT/CT, MR and Optical Imaging in Small Animals *Youngho Seo, PhD* Assistant Adjunct Professor of Radiology UCSF *Michael F. Wendland, PhD* Adjunct Professor of Radiology UCSF *Ella Fung Jones, PhD* Assistant Adjunct Professor of Radiology UCSF Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-301
18 Feb,2009 2-3:30PM	Statistical Considerations of Using Medical Imaging Techniques in Clinical Trials With rapid advancement in imaging technology, quantitative and semi-quantitative measurements on medical images have been increasingly used in clinical trials. These measurements can be used as the primary or the exploratory endpoints in safety and efficacy evaluation. Often these image techniques can demonstrate changes earlier than time required to observe clinical changes and can make repeated observations possible. The drawbacks are that they may introduce false positive and negative information, the logistic complications in clinical trial management, additional variation introduced by different equipments from different manufacturers, experience of technicians and radiologists. Gold standards are not always available and precision is more important than the accuracy in longitudinal changes. In this talk, I will discuss the characteristics of a useful imaging marker, the quality control during data collection (two-dimensional quality control processing chart), and a new approach for analysis of change of images. *Dr. Ying Lu* Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
19 Feb,2009 5:15 PM reception 5:30 Lecture	"Potential Medical Imaging Applications of Undersampled Acquisition and HYPR Reconstruction in the Post Nyquist - Post Cartesian Era" First Annual Bruce H. Hasegawa Memorial Lecture *Charles A. Mistretta, PhD* J.R. Cameron Professor of Medical Physics and Radiology Department of Medicine University of Wisconsin Madison, WI Contact: katie.murphy@radiology.ucsf.edu more...	Seminar	Parnassus HSW-300
04 Mar,2009 2-3:30PM	Getting in Phase with 7T MRI The high field strength of 7T MRI makes it possible to acquire MR images at spatial resolutions up to 200 microns in less than 10 minutes. Imaging the phase of the MR signal quantifies the magnetic field distortions from compounds such as iron and calcium. I will present our 7T MR phase images recently published in Annals of Neurology (Hammond et al, 2008;64:707-713) and NeuroImage (Hammond et al, 2008;39:1682-1692) acquired in Surbeck Laboratory for Advanced Imaging at Mission Bay from volunteers and subjects with neurological disorders including traumatic brain injury, brain tumors, multiple sclerosis and other neurodegenerative diseases. *Kate Hammond* PhD Candidate, UCSF/UCB Joint Graduate Group in Bioengineering kehammond@gmail.com/Ph: 650-387-6065 Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conference room
11 Mar,2009 NOON	Giving and Receiving Feedback Featuring the following Speakers: *Andrew Parker, PhD* Faculty and Staff Assistance Program, UCSF *Aliya Qayyum, MBBS* Associate Professor of Radiology Director, Diagnostic Radiology Residency Prog. UCSF Dept. of Radiology & Biomedical Imaging *Bonnie N. Joe, MD, PhD* Assistant Professor in Residence Chief, Women's Imaging, Mt.Zion Medical Center UCSF Dept. of Radiology & Biomedical Imaging *David A. Saloner, PhD* Professor in Residence Director, Neurovascular/Neurointerventional RIG Director, Vascular Resarch Center, VAMC UCSF Dept. of Radiology & Biomedical Imaging *Richard A. Sollitto, MD* Professor of Clinical Radiology Chief of Radiology, UCSF Mt. Zion Hospital Chief of Radiology, Ambulatory Care Clinics UCSF Dept. of Radiology & Biomedical Imaging *Susan D. Wall, MD* Professor Emeritus Vice-Chair, Academic Affairs UCSF Dept. of Radiology & Biomedical Imaging Contact: katie.murphy@radiology.ucsf.edu	Seminar	Parnassus N-217
24 Mar,2009 1PM	Aging Brain: Neuroanatomic Changes, Their Modifiers, and Cognitive Correlates Success in diagnosing and treating age-related brain disease depends on understanding normative and optimal aging, and neuroimaging is a vital tool in advancing toward that goal. Studies of the brains of healthy adults reveal uneven, differential shrinkage of the parenchyma and expansion of the ventricular system, with the prefrontal cortices evidencing the largest magnitude of age-related differences, and the tertiary association (prefrontal and parietal) cortices, the neostriatum, and the cerebellum showing the greatest rate of shrinkage. Although findings vary across samples, reduced regional brain volumes and steeper longitudinal declines are usually associated with lower cognitive performance in specific domains. The observed pattern of differential brain aging is significantly modified by negative and positive f! ! actors. Vascular risk factors, even at the upper end of the ostensibly normal range, may underpin significant changes in brain morphology and suboptimal cognitive performance. Notably, the negative effects of vascular risk are especially apparent in the regions deemed most vulnerable to aging, and the positive modifying influence of aerobic fitness is clearest in the same age-sensitive areas. Genetic variation may have a significant impact on age-related changes in brain and cognition, although the evidence is still scarce. The important role of vascular risk in shaping the trajectories cognitive and cerebral aging makes their alleviation a most worthy therapeutic goal. *Naftali Raz, Ph.D.* Institute of Gerontology 87 E. Ferry St. Wayne State University Detroit, MI 48202 Contact: natalie.bareis@ucsf.edu	Seminar	VAMC CIND, Building 13
26 Mar,2009 NOON	7-T Magnetic Resonance Imaging MRI in Dementia: New Insights from 7T *Christopher P. Hess, MD, PhD* Assistant Professor in Residence Department of Radiology and Biomedical Imaging UCSF New Method for MR Signal Excitation *Xiaoliang Zhang, PhD* Associate Professor in Residence Department of Radiology and Biomedical Imaging UCSF High-Resolution Phase Imaging at 7T *Kate E. Hammond* PhD Candidate UCSF/UCB Joint Graduate Group in Bioengineering Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-301
30 Mar,2009 10am to 12 noon weekly	Course: Statistical Methods for Radiology and Biomedical Imaging Spring 2009 -- Radiology 170.06* Course Director: John Kornak Lecture Series: 10 x 2 hour lectures, Mondays 10 am -- 12 noon, beginning 03/30/09 Location: China Basin Landing Classroom (CBL 331), Ste. 350, Lobby 6, 185 Berry St. For directions see: http://cmfi.ucsf.edu/contact <http://cmfi.ucsf.edu/contact> This course will focus on statistical methods particularly relevant to researchers working in the Radiological and Biomedical Imaging sciences. The subject matter will concentrate on understanding the applications and limitations of statistical methods for imaging and not on developing technical detail. Lectures: 1) Basic Statistics -- Ying Lu (3/30) 2) Linear Models and voxel-based statistics -- Valerie Cardenas-Nicolson (4/6) 3) Longitudinal, Correlated Data and Time Series -- John Kornak (4/13) 4) Discriminant Analysis and Classification -- Caixia Li (4/20) 5) Survival Analysis -- John Kornak (4/27) 6) Bayesian Statistics -- John Kornak (5/4) 7) Statistical Image Analysis - John Kornak (5/11) 8) How to organize your datasets -- Bill Chu (5/18) 9) Meta-Analysis/Imaging Clinical Trials -- Ying Lu (6/1) 10) Image Data Mining -- Karl Young (6/8) Contact: john.kornak@ucsf.edu	Seminar	CBL Calssroom - 331
10 Apr,2009 NOON	CT, Radiation, Children...and the Bigger Picture: A Primer for Radiologists *Donald P. Frush, MD* Professor of Radiology and Pediatrics Faculty, Medical Physics Graduate Program Chief, Division of Pediatric Radiology Duke University Medical Center Durham, North Carolina Contact: katie.murphy@radiology.ucsf.edu more...	Grand Rounds	Parnassus HSW-300
15 Apr,2009 2-3PM	Depression and Anxiety: Perspectives from Psychotic major depression and William's Syndrome The DSM-IV currently categorizes disorders based on various combinations of symptom clusters, and doesn�t distinguish disorders based on disease specific etiologies. Current neuroscience research in the area of disease has begun to focus more understand biological mechanism that might better dissociate diseases based on the underlying etiologies. The aim of the research presented here was to find functional and structural correlates that not only distinguished the populations studied (psychotic major depression (PMD) and William�s syndrome (WS)) from matched controls, but also related to specific phenotypic characteristics of those disorders. A verbal declarative memory task was used to explore changes of frontal and hippocampal function in individuals with PMD as compared to individuals with non-psychotic major depression (NPMD) and healthy controls. Insular morphometry was also used as a biomarker, due to its involvement in autonomic regulation and its cognitive role in self-awareness, in the PMD population with regard to psychosis and in the WS population with regard to specific phobias. The results not only distinguish the test populations from controls, but suggest some of the underlying mechanisms that relate to specific behavioral characteristics of PMD and WS. *Jeremy Cohen, Ph.D.* Postdoctoral fellow Stanford University CIBSR 401 Quarry Road, MC 5795 Stanford, CA 94305 http://cibsr.stanford.edu Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
06 May,2009 5:15 reception 5:30 pm lecture	MR of Neural Entrapment Syndromes Mini N. Pathria, MD Professor of Clinical Radiology School of Medicine University of California San Diego Contact: katie.murphy@radiology.ucsf.edu more...	Grand Rounds	Parnassus HSW-300
21 May,2009 NOON	Novel Imaging Methods of Assessing Treatment Response and Monitoring Angiogenesis in Tumors *Dushyant Sahani, MD* Associate Professor of Radiology Harvard Medical School Director of CT Division of Abdominal Imaging and Intervention Massachusetts General Hospital Boston, MA Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus N-217
28 May,2009 NOON	Understanding Professional Liability: What Is Your Risk? *Susan L. Penney, JD* Director Medical Risk Management UCSF Medical Center Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus HSW-301
03 Jun,2009 NOON	Womens Imaging Grand Rounds: Imaging and Molecular Biomarkers for Assessing Breast Cancer Response to Neoadjuvant Chemotherapy: Highlights of the I-SPY trial *Laura J. Esserman, MD, MBA* Professor of Surgery and Radiology, UCSF Director, Carol Franc Buck Breast Care Center Associate Faculty Institute for Health Policy Studies *Nola M. Hylton, PhD* Professor of Radiology Director, Breast MRI Research Program Department of Radiology & Biomedical Imaging, UCSF *Bonnie N. Joe, MD, PhD* Assistant Professor of Radiology Chief, Women's Imaging Section Department of Radiology & Biomedical Imaging, UCSF UCSF-Mt. Zion Hospital, San Francisco *Laura van't Veer, PhD* Head of Molecular Pathology Netherlands Cancer Institute Amsterdam, NL Contact: katie.murphy@radiology.ucsf.edu more... and more...	Grand Rounds	Parnassus N-225
09 Jun,2009 10-11AM	Simultaneous EEG-fMRI and Other New Ways to Probe Brain Function *Truman R. Brown,* Director of MR Research, CUMC Percy Kay and Vida L.W. Hudson Professor of Biomedical Engineering Professor of Radiology Columbia University Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
10 Jun,2009 2-3PM	Optimisation, validation and application of quantitative magnetic resonance image analysis techniques to study brain morphology in temporal lobe epilepsy Temporal lobe epilepsy (TLE) is a devastating neurological disorder with a known hereditary component. However, studies involving the isolation of the specific genes involved have not been successful. In order to simplify the understanding of the phenotype, an intermediate and heritable biomarker (endophenotype) may be studied. It has been established that brain volume and the morphometry of a number of brain structures have a high heritable component. Hence, quantitative MRI (QMRI) abnormalities may be investigated as potential endophenotypes in TLE. An essential step in realizing this goal is the establishment of reliable and robust tools for automated MRI-based in-vivo measurements of brain measures. For this reason, this work focuses on investigating the optimisation, validity and reliability of QMRI techniques for the measurement of geometric properties of brain structures. A reliable automated technique is necessary for future large scale genetic studies, where large amounts of data are needed to be produced efficiently, and where manual methods are simply not practical. The automated QMRI technique under investigation is subsequently applied to a cohort of TLE patients and their unaffected siblings in a preliminary study to investigate the heritability and hence, endophenotypic potential of identified abnormalities. *Cathy Scanlon* Center for Imaging of Neurodegenerative Diseases San Francisco VA Medical Center Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
11 Jun,2009 12-1PM	Patterns of imaging changes in genetic frontotemporal lobar degeneration *Dr Jonathan Rohrer* Clinical Research Fellow Dementia Research Centre Institute of Neurology Queen Square London	Seminar	VAMC Building 13, Conference Room
11 Jun,2009	T32 Research Training Grant Program Presentations Come hear UCSF Department of Radiology & Biomedical Imaging T32 Training Grant Recipients discuss their research! *Jeremy Collins, MD* PGY5 Resident *Amita Kamath, MD* PGY5 Resident *Maureen Kohi, MD* PGY4 Resident *Dorota Wisner, MD, PhD* PGY5 Resident Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-301
17 Jun,2009 11-12PM	Computational neuroanatomy using MRI *Bruce R. Fischl, Ph.D.* Associate Professor of Radiology Harvard University Massachusetts General Hospital Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
18 Jun,2009 9AM-5PM	Frontiers in Imaging of Neurodegenerative Diseases: A New National Biotechnology Research Resource (NCRR) The overall goal of this Symposium is to provide the attendees with advanced knowledge concerning state-of-the-art high-field neuroimaging, focusing on multimodality MRI at 3 to 7 Tesla and PET of neurodegenerative diseases. Pertinent technical aspects of MR data acquisition and processing at high field will be discussed in the morning. Speakers will specifically address MR data acquisition, reconstruction, processing, and analysis of structural, perfusion, and diffusion spectrum MRI data. The afternoon will be dedicated to hot-topic clinical applications in dementias and other neurodegenerative diseases. Contact: natalie.bareis@ucsf.edu more...	Seminar	VAMC SF Marriott Pac Rm C
19 Jun,2009 3:30-4:30PM	Warping of Diffusion Tensor Images *Dr. Dongrong Xu* Assistant Clinical Professor Department of Psychiatry - Child/Adolescent Psychiatry Columbia University, NY Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
22 Jun,2009	Quantitative Musculoskeletal Imaging at UCSF: Technique Development and Clinical Applications *Sharmila Majumdar, PhD* Professor of Radiology, UCSF *Galateia Kazakia, PhD* Assistant Professor of Radiology *Benjamin Ma, MD* Assistant Professor of Orthopaedic Surgery	FAIR	Parnassus HSW-302
24 Jun,2009 2-3PM	Automated MRI-based classification of primary progressive aphasia variants Degeneration of language regions in the dominant hemisphere can result in primary progressive aphasia (PPA), a clinical syndrome characterized by progressive deficits in speech and/or language function. Recent studies have identified three variants of PPA: progressive non-fluent aphasia (PNFA), semantic dementia (SD) and logopenic progressive aphasia (LPA). Each variant is associated with characteristic linguistic features, distinct patterns of brain atrophy, and different likelihoods of particular underlying pathogenic processes, which makes correct differential diagnosis highly clinically relevant. Evaluation of linguistic behavior can be challenging for non-specialists, and neuroimaging findings in single subjects are often difficult to evaluate by eye. We investigated the utility of automated structural MR image analysis to discriminate PPA variants (N = 86) from each other and from normal controls (N = 115). T1 images were preprocessed to obtain modulated grey matter (GM) images. Feature selection was performed with principal components analysis (PCA) on GM images as well as images of lateralized atrophy. PC coefficients were classified with linear support vector machines, and a cross-validation scheme was used to obtain accuracy rates for generalization to novel cases. The overall mean accuracy in discriminating between pairs of groups was 92.2%. For one pair of groups, PNFA and SD, we also investigated the utility of including several linguistic variables as features. Models with both imaging and linguistic features performed better than models with only imaging or only linguistic features. These results suggest that automated methods could assist in the differential diagnosis of PPA variants, enabling therapies to be targeted to likely underlying etiologies. *Dr. Stephen M. Wilson* UCSF Department of Neurology 350 Parnassus Ave, Suite 905 San Francisco, CA 94143 E-mail: swilson@memory.ucsf.edu Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
22 Jul,2009 2-3PM	High Resolution 3D Functional MRI at 7 Tesla Ultra-high magnetic field strengths for neuroimaging have many advantages especially for higher image signal-to-noise ratio making high spatial resolution imaging possible. However, multiple different signal parameters, including T2, T2* and BOLD contrast dramatically change at ultra high fields requiring new pulse sequences. Experiments performed in human brain show the first 3D single-shot images at 7T obtaining columnar level and ocular dominance column (ODC) resolution in the V1 cortex using sub-millimeter resolutions in fMRI by means of the new 3D pulse sequences. These novel imaging tools take fMRI to a new level in the human brain revealing 3D neuronal activity in cortical layers in sub-cortical specific spatial mapping. This novel high resolution fMRI is applicable to studies of layer specific functional connectivity and activity in ensembles of nerves for nerve network analysis. *David Feinberg, MD, PhD* Adj. Professor Radiology, UCSF Advanced MRI Technologies, Sebastopol, CA Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
03 Aug,2009 12:30-1:30PM	Resting-State fMRI: Principles and (Potential) Clinical Applications As our understanding of resting-state networks (RSNs) has advanced, so too have the potential applications of this new modality to pressing research and clinical questions. In the basic research realm, this talk will consider how RSNs have been used to study brain connectivity across a number of canonical brain networks. We will focus particularly on how cognitive and emotional attributes may be reflected in the connectivity strength of these networks and on how these networks adapt and interact in the setting of a task. The bulk of the talk will be devoted to the numerous clinical RSN studies that have come out in the last five years. While highlighting some of the more plausible applications (in Alzheimer�s disease for example) we will consider both the strengths and weaknesses of this approach in studying neuropsychiatric disorders. The talk will conclude with a discussion of how we might enhance the clinical utility of RSN analyses to allow for a better understanding of pathogenesis, earlier and more accurate diagnoses, and early objective markers of treatment effect. *Michael D. Greicius, M.D.* Assistant Professor of Neurology and Neurological Sciences Stanford University Contact: natalie.bareis@ucsf.edu	Seminar	VAMC CIND, Building 13
05 Aug,2009 2-3PM	Imaging for White Matter Alterations Associated with ApoE-4 Genotype: A DTI Study Apolipoprotein E-4 (ApoE-4) has been identified as a major genetic factor contributing to severe cognitive impairments in dementia like Alzheimer�s disease (AD), although the underlying neural mechanisms by which the genetic factor influences the structure and performance of the brain are poorly understood. The present diffusion tensor imaging (DTI) study aims to identify the ApoE-4 associated WM alterations in healthy population, and compare the obtained WM alterations patterns with those caused by aging and AD. The correlations and interactions among the subject ages, ApoE genotypes, neurocognitive testing scores, and DTI measurements will be discussed. *Wang Zhan, Ph.D.* Assistant Adjunct Professor University of California, San Francisco Center for Imaging of Neurodegenerative Diseases San Francisco Veterans Affairs Medical Center Contact: natalie.bareis@ucsf.edu	Seminar	VAMC CIND, Building 13
10 Aug,2009 NOON	Prostate *Recent Advances in Prostate Imaging* John Kurhanewicz, PhD Professor in Residence Department of Radiology and Biomedical Imaging *Clinical Applications of MRI MRSI of the Prostate* Antonio Westphalen, MD Assistant Professor in Residence Abdominal Imaging Section Department of Radiology and Biomedical Imaging Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW-300
02 Sep,2009 2:00-3:30	How to choose a scientific direction, a project, write a scientific paper, and a grant *Dr. Michael Weiner* Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13 Conf Room
03 Sep,2009 NOON	"Advances in Electromagnetic Brain Imaging" *Srikantan Nagarajan, PhD* Director, Biomagnetic Imaging Laboratory Professor Department of Radiology and Biomedical Imaging University of California, San Francisco Contact: katie.murphy@radiology.ucsf.edu	Progress in Radiology	Parnassus N-217
08 Sep,2009 1-2PM	Hippocampal Subfields: More evidence why regional information matters *Susanne Mueller, M.D.* Associate Adjunct Professor of Radiology University of California, San Francisco Center for Imaging of Neurodegenerative Diseases Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
15 Sep,2009 1:00-5:30 PM	Department of Radiology & Biomedical Imaging Sixth Annual Departmental Research Symposium Contact: katie.murphy@radiology.ucsf.edu	Seminar	Parnassus Cole Hall and Millberry Union
22 Sep,2009 3:30p-4:30p	Structural brain imaging and neuropsychology for the detection of early Alzheimer�s disease Many studies have examined patterns of cerebral atrophy in patients with mild cognitive impairment (MCI) in order to identify the earliest changes in the brain associated with Alzheimer�s disease (AD) and to predict which subjects will progress to a diagnosis of AD. While there is variability across such studies, the most consistent findings are of volumetric changes within the hippocampus or adjacent medial temporal lobes (MTL) (perirhinal, entorhinal and parahippocampal cortices). These findings are consistent with the observation that the earliest histopathalogical markers of AD occur in the MTL. Although these results demonstrate the value of structural imaging for the detection of early AD, other studies have demonstrated that the progression of MCI to AD is better predicted using neuropsychological measures of dementia, or a combination of neuropsychological measures and structural imaging of the MTL. The accuracy of such techniques may be enhanced using neuropsychological tests that are sensitive to MTL function rather than to global memory functions. Neuropsychological tests will be presented which were designed to be sensitive to hippocampal function using current concepts in memory research. The tests were given to a group of patients (n=5) with circumscribed hippocampal lesions whose damage was confirmed using detailed whole brain volumetric analysis. One of the primary roles of the hippocampus is to encode new associations between previously unrelated items. Thus, the tests relied predominantly on associative memory paradigms, and testing was performed using a recognition format. It is suggested that such tests could optimize the detection of the clinical progression of MCI to AD when given in conjunction with structural imaging. *Dr. Peter Bayley* Contact: elena.pozdniakova@va.gov	Seminar	Parnassus C309
24 Sep,2009 4:00-5:00	Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: Different Degrees of the Same or not the Same Altogether Abstract: Temporal lobe epilepsy (TLE) is the most common form of partial epilepsy. Based on the appearance on the MRI, two sub-types are distinguished: TLE with mesial temporal sclerosis (MTS) and TLE with normal appearing MRI. While the two forms share many clinical features, there are also differences, most notably the outcome after epilepsy surgery which is highly successful in TLE with MTS but less so in TLE with normal MRI. This raises the question how these two subtypes relate to each other. Is TLE with normal MRI indeed just a less advanced form of TLE with MTS or is it eventually a different form of TLE which needs a different surgical approach. This talk will give an overview how neuroimaging could help to further investigate this question. *Dr. Susanne Mueller* Contact: elena.pozdniakova@va.gov	Seminar	Parnassus C309
06 Oct,2009 11AM-noon	A new Approach to Regularization and Delay-Dispersion Improvement in Quantitative DSC Perfusion Measurements A new approach for residue function deconvolution and regularization is suggested. The �small derivatives� assumption in regular Tikhonov regularization is not valid, especially in short Mean Transition Time (MTT) regimes, and usually results in flow underestimation. An iterative model-based approach is suggested to correct this issue. If they are not incorporated in the model, the method is sensitive to delay and dispersion. For the correction, Delay/Dispersion Correction (DDC), an optimization based method, was introduced. DDC could characterize the dispersion transport functions and estimate delay time with the fewest assumptions on the nature of these effects. The method was examined using computer simulations, phantom and in vivo measurements. *Dr. Behzad Ebrahimi* Contact: elena.pozdniakova@va.gov	Seminar	VAMC Conf room CIND Bldg 13
07 Oct,2009 2:00PM	RF Pulse Design Method in Parallel Transmission for MRI Parallel transmission using multiple transmit channels has emerged as an effective method to shorten the duration of multidimensional spatially selective excitation, which have a number of important applications, including B1 field inhomogeneity correction in high-field MRI. In this presentation, the design algorithm and optimization method for RF design in parallel transmission will be described and discussed. *Dr. Yinan Liu* Contact: elena.pozdniakova@va.gov	Seminar	VAMC Conf room CIND Bldg 13
09 Oct,2009 1-2PM	Effects of low-level exposure to sarin and cyclosarin on brain function and brain structure in 1991 GW veterans A munitions dump at Khamisiyah, Iraq was destroyed during the Gulf War (GW) in 1991. Later, it was discovered that the dump contained the organophosphate chemical warfare agents, potentially exposing more than 100,000 US troops to sarin and cyclosarin. Although little is known about the long-term neurobehavioral or neurophysiological effects of low-dose exposure to sarin/cyclosarin in humans, recent studies have reported neurobehavioral decrements in certain functional domains (e.g., manual dexterity and visuospatial functions) and reduced white matter volume in the brain with higher estimated levels of presumed sarin/cyclosarin exposure. The goal of this study is to replicate and expand these findings. *Linda Chao, Ph.D.* Assistant Adjunct Professor University of California, San Francisco Center for Imaging of Neurodegenerative Diseases Department of Radiology Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
15 Oct,2009 5:00 reception; 5:30 Lecture	Earl Miller Memorial Lecture MRI of Non-alcoholic Fatty Liver Disease *Claude B. Sirlin, M.D.* Associate Professor In Residence Department of Radiology University of California, San Diego Chief of Body MRI Head, Liver Imaging Research Group Head, Body Imaging Clinical Research University of California Medical Center, San Diego Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus HSW-300
21 Oct,2009 2-3PM	Cross-sectional and longitudinal DTI studies of white matter alterations in Frontotemporal Lobar Degeneration (FTLD) *Dr. Yu Zhang* Center for Imaging of Neurodegenerative Diseases San Francisco VA Medical Center University of California, San Francisco Contact: natalie.bareis@ucsf.edu	Seminar	VAMC Building 13, Conference room
28 Oct,2009 5:00 reception 5:30 pm lecture	Eighth Annual T. Hans Newton Lecture "IMAGING OF PEDIATRIC HEARING LOSS: Correlating Genotype with Phenotype" *Caroline Robson, MB,ChB* Assistant Professor in Radiology at Harvard Medical School Executive Vice Chair, Radiology, Director of Magnetic Resonance Imaging, Director of Head and Neck Imaging Childrens Hospital Boston Boston, MA Contact: katie.murphy@radiology.ucsf.edu	Grand Rounds	Parnassus HSW-300
19 Nov,2009 NOON	INFORMATICS "So What is the IDR and How Do You Connect It To Imaging Studies?" David E. Avrin, MD, PhD Professor of Clinical Radiology Director, Informatics and Image Processing/Display Vice-Chair, Informatics Department of Radiology and Biomedical Imaging, UCSF "Clinical Archetype Selection and PHI Security for the Identification of Radiology Cohorts" Rob Wynden Manager, Research and Development Academic Research Systems UCSF "Using Open-Source Tools to Manage and Distribute Research Imaging Datasets" Wyatt Tellis, PhD Project Manager Laboratory for Radiological Informatics Department of Radiology and Biomedical Imaging UCSF Contact: katie.murphy@radiology.ucsf.edu	FAIR	Parnassus HSW303