This NMR core facility provides the resources and technical expertise required to identify, validate and implement robust, quantitative, noninvasive magnetic resonance-based metabolomic biomarkers of human disease and therapeutic response. We integrate specialized NMR techniques with expert knowledge and cutting edge equipment to perform research focused on studies of ex vivo tissues, biofluids, and pre clinical cell and tissue culture bio-reactivity and in murine models of human disease using state of the artmultinuclear 31P, 1H 13C, hyper-polarized 13C, 15N 31P and 19F MR spectroscopy (MRS), high-resolution magic angle spinning (HR-MAS) spectroscopy (HR-MAS) and MR imaging (MRI) techniques. The Biomedical portion of the Lab houses a high field multi nuclear 500 MHz HR-MAS NMR spectrometer and a 600 MHz micro-imaging, HR-MAS spectrometer that are uniquely integrated with a Hyper Sense™ (Oxford Instruments) DNP hyper polarizer.  High-field spectro-meters (400 MHz, 2 500 MHz, 2 600 MHz and an 800 MHz) with multi-nuclear capabilities and sensitive cryoprobes are also available. The combination of NMR technologies found in this core facility are unparallel.