EVALUATION OF NON-INVASIVE BIOMARKERS SING IN VIVO HIGH FIELD MR IMAGING ANS SPECTROSCOPY

ICURP – UC Discovery Grant in Information Technology for Life Sciences, awarded to UCSF with industry partner GE Healthcare Technology (8/9/2006 to 8/8/2010)

The current research project expands and extends a very successful, long-term partnership between researchers at UCSF and UCB and their colleagues at the California-based research and development laboratory of General Electric Healthcare Technologies. The five-year project described below is supported through the mechanism of UC Discovery grants, administered by the Industry-University Cooperative Research Program of California. The Principle Investigator is Professor Sarah Nelson at UCSF, and Professor Thomas Budinger at UC Berkeley.

Through this collaboration, we are developing and evaluating quantitative, non-invasive biomarkers as tools for basic and translational research in human subjects. The increasing desire to rapidly and cost-effectively develop new treatments for patients with diseases such as cancer, osteoarthritis, osteoporosis and multiple sclerosis has put a premium on two types of research. The first involves identifying non-invasive biomarkers for routine use in humans, and the second is on developing the acquisition and analysis tools to interpret the resulting data.

These advances contribute to understanding basic biology, to performing pre-clinical studies of new drugs, to stratifying patients for specific therapies and to monitoring responses to therapy. Magnetic Resonance (MR) imaging is widely used in human studies for assessing changes in tissue morphology, but conventional techniques suffer from a lack of sensitivity and specificity. The whole body high field scanners that have been installed in the Institute for Quantitative Biomedical Research (QB3) at UCSF provide the possibility for increasing the sensitivity of conventional MR imaging techniques and makes feasible the routine application of new methods that assess physiological and metabolic properties of the tissue. These data reflect markers such as blood flow, microvascular density, disruption of tissue architecture and changes in basic biochemical properties at the cellular and whole organ level. Interpretation of the complex, multi-dimensional datasets acquired as part of these studies requires the development of sophisticated reconstruction and post-processing tools that can quantify relevant endpoints.

As a collaborative effort between a corporate leader in medical imaging technology, GE Healthcare, and scientists at UCSF and UCB who are engaged in education and innovative research, this project builds on past success and is stimulating new avenues for investigation. This project has already received supplemental funding through the UC Discovery grant program, to add investigation of hyperpolarized compounds.

This collaboration has broad ramifications in the following areas:
• The new imaging and processing methods are well suited to translational technology, meaning they can transition more quickly from research into clinical practice.
• The University – Industry partnership is beneficial to the California economy, stimulating both the public and private sectors, so that both benefit from the synergy of academic and industry research.
• The original project, along with the supplement, significantly expand educational opportunities for training graduate students, post-doctoral scholars, and medical residents not only in high field MR, but also in the development of non-invasive biomarkers for basic and translational research.

Oh J, Han ET, Lee MC, Nelson SJ, Pelletier D. Multislice brain myelin water fractions at 3T in multiple sclerosis. J Neuroimaging. 2007 Apr;17(2):156
Cha S, Lupo JM, Chen MH, Lamborn KR, McDermott MW, Berger MS, Nelson SJ, Dillon WP. Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol. 2007 Jun-Jul;28(6):1078-84
Chuang CF, Chan AA, Larson D, Verhey LJ, McDermott M, Nelson SJ, Pirzkall A. Potential value of MR spectroscopic imaging for the radiosurgical management of patients with recurrent high-grade gliomas. Technol Cancer Res Treat. 2007 Oct;6(5):375-82.
Hammond KE, Lupo JM, Xu D, Metcalf M, Kelley DA, Pelletier D, Chang SM, Mukherjee P, Vigneron DB, Nelson SJ. Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases. Neuroimage. 2008 Feb 15;39(4):1682-92. Epub 2007 Nov 7
Hammond KE, Lupo JM, Banerjee S, Kelley DA, Vigneron DB, Chang SM, Mukherjee P, Nelson SJ. Phase-Based Quantification of Magnetic Susceptibility in Healthy Volunteers and Patients with Neurological Disorders at 7T. Accepted for poster presentation at the 16th Annual Meeting of the International Society for Magnetic Resonance in Medicine. (Toronto, Ontario 3-9 May 2008).
Hammond KE, Mukherjee P, Chang SM, Lupo JM, Xu D, Kelley DA, Vigneron DB, Nelson SJ. Phase Imaging of Healthy Brains and Patients with Multiple Sclerosis or Brain Tumors at 7T. ISMRM Workshop: Advances in High Field MR. Pacific Grove, CA, March 2007, p 63.
Hammond KE, Lupo JM, Xu D, Kelley DAC, Vigneron DB, Nelson SJ. Phase Imaging of the Human Brain at 7T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 682.
Hammond KE, Mukherjee P, Chang SM, Lupo JM, Xu D, Kelley DAC, Vigneron DB, Nelson SJ. Phase Imaging of Brain Tumor Patients at 7T ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 835.
Khayal IS, McKnight TR, Lamborn KR, McGue C, Chang SM, Cha S, Nelson SJ, Vigneron DB. Diffusion MR Imaging Parameters Aid in Subtyping Newly Diagnosed Low Grade Gliomas. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 18.
Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ. Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T. Magn Reson Med. 2007 Nov;58(5):886-92
Li Y, Xu D, Chen AP, Vigneron DB, Nelson SJ. Proton spectroscopy of human brain at 3T and 7T comparing of signal-to-noise ratios, spectral linewidths and relaxation times. Magn. Reson. In Med. (submitted).
Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ. Three-Dimensional, J-Resolved H-1 MRSI of Volunteers and Patients with Brain Tumors at 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1363.
Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ. Novel Techniques for Acquisition and Analysis of Metabolite Levels for H11 MR Spectroscopic Imaging in Patients with Gliomas. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 412.
Lupo JM, Cha S, Chang SM, Nelson SJ. Analysis of metabolic indices in regions of abnormal perfusion in patients with high-grade glioma. AJNR Am J Neuroradiol. 2007 Sep;28(8):1455-61.
Lupo JM, Chen AP, Cunningham CH, Bok R, Kurhanewicz J, Vigneron DB, and Nelson SJ. Hyperpolarized dynamic 13C lactate imaging of disease progression in a Transgenic Mouse Model of Prostate Cancer. (in preparation)
Lupo JM, Chang SM, Nelson SJ. The role of high field susceptibility-weighted imaging in the characterization of high-grade gliomas. (in preparation)
Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. GRAPPA-based Susceptibility-Weighted Imaging of Normal Volunteers and Brain Tumor Patients at 7T. (in review Magn Reson Imaging, December 2007)
Lupo JM, Chen AP, Cunningham CH, Bok R, Kurhanewicz J, Vigneron DB, and Nelson SJ. Non-parametric Analysis of Hyperpolarized Dynamic 13C Lactate Imaging in a Transgenic Mouse Model of Prostate Cancer. Accepted for oral presentation at the 16th Annual Meeting of the International Society for Magnetic Resonance in Medicine. (Toronto, Ontario 3-9 May 2008).
Lupo JM, Chang SM, and Nelson SJ. Using 7T susceptibility-weighted imaging to aid in the characterization of high-grade gliomas. Accepted for poster presentation at the 16th Annual Meeting of the International Society for Magnetic Resonance in Medicine. (Toronto, Ontario 3-9 May 2008).
Lupo JM, Hammond KE, Chang SM, Nelson SJ. Imaging Treatment Effects in Brain Tumors using SWI. Proceedings of the Society for Neuro-Oncology 12th Annual Scientific Meeting. (Dallas, Texas, 15-18 November 2007).
Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. Imaging Susceptibility in Brain Tumors at 7 Tesla. Joint Molecular Imaging Conference. (Providence, Rhode Island, 8-11 September 2007).
Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. GRAPPA-based Susceptibility-Weighted Imaging Applied to Brain Tumor Patients at 3T & 7T. Proceedings of the International Society for Magnetic Resonance in Medicine Workshop on Advances in High Field MR. (Pacific Grove, CA, 25-28 March 2007).
Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. Susceptibility-weighted imaging of brain tumor patients at 7T using an autocalibrating parallel technique. Proceedings of the 15th Annual Meeting of the International Society for Magnetic Resonance in Medicine. (Berlin, Germany 19-25 May 2007).
Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. GRAPPA-based susceptibility-weighted imaging of normal volunteers and brain tumor patients at 7T. Magn. Reson. Med. (submitted).
Lupo JM, Banerjee S, Hammond KE, Kelley DAC, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. Susceptibility-weighted imaging of brain tumor patients at 7t using an autocalibrating parallel technique. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1769.
Lupo JM, Banerjee S, Hammond K, Xu D, Kelley D, Vigneron D, Majumdar S, Nelson S. Imaging susceptibility in brain tumors at 7 tesla. Joint Molecular Imaging Conference, Providence, RI, September 2007, p 683.
McKnight TR, Lamborn KR, Love TD, Berger MS, Chang S, Dillon WP, Bollen A, Nelson SJ. Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas. J Neurosurg. 2007 Apr;106(4):660
Nelson SJ, Xu D, Hammond KE, Lupo J, Chen A, Kelley DA, Vigneron DB. Acquisition of 7T 3D MRS imaging data from patients with brain tumors. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 16.
Nelson SJ, Xu D, Hammond K, Lupo J, Chen A, Kelley D, Chang S, Vigneron D. High Field 3-D H-1 MRSI Data from Patients with Brain Tumors. Joint Molecular Imaging Conference, Providence, RI, September 2007, p 645.
Osorio JA, Ozturk-Isik E, Xu D, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ. 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil. J Magn Reson Imaging. 2007 Jul;26(1):23-30.
Osorio J, Xu D, Cunningham C, Chen A, Kerr AB, Pauly JM, Vigneron DB, Nelson SJ. Design of Cosine Modulated Very Selective Suppression Pulses for Magnetic Resonance Spectroscopic Imaging at 3T. Magn Reson in Med (submitted).
Osorio JA, Xu D, Cunningham CH, Chen AP, Pauly JM, Vigneron DB, Nelson SJ. Improved Coverage of Brain Tumors with 1H MRSI Using Cosine Modulated Very Selective Suppression Pulses at 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1239.
Ozturk-Isik E, Chen AP, Crane JC, Xu D, Han ET, Chang SM, Vigneron DB, Nelson SJ. Elliptical SENSE with Effective 9 Fold Scan Time Reduction for Small FOV 3D MR Spectroscopic Imaging of Glioma Patients at 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 47.
Ozturk-Isik E, Banerjee S, Chang SM, Majumdar S, Nelson SJ, Vigneron DB. 3D Parallel Ellipsoidal Samplings for Fast Proton MR Spectroscopic Imaging of Gliomas at 3T. Joint Molecular Imaging Conference, Providence, RI, September 2007, p 36.
Park I, Tamai G, Lee MC, Chuang CF, Chang SM, Berger MS, Nelson SJ, Pirzkall A. Patterns of recurrence analysis in newly diagnosed glioblastoma multiforme after three-dimensional conformal radiation therapy with respect to pre-radiation therapy magnetic resonance spectroscopic findings. Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):381-9. Epub 2007 May 21
Park I, Chen AP, Zierhut ML, Crane JC, Cunningham CH, Vigneron DB, Nelson SJ. Lactate Detection for Gliomas Patients Using Lactate-Edited 3D 1H MR Spectroscopic Imaging with Flyback Echo-Planar Readout Gradient at 3T ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 775.
Xu D, Han ET, Hess CP, Kelley DAC, Vigneron DB, Metcalf M, Mukherjee P. 7T Diffusion Tensor Imaging and Q-Ball Imaging of the Human Brain in Vivo. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1466.
Xu D, Hess CP, Kelley DAC, Nelson SJ, Vigneron DB, Mukherjee P. Diffusion Tensor and High Angular Resolution Diffusion Imaging of the Brain. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 104.
Xu D, Chen AP, Cunningham CH, Kelley DAC, Pauly JM, Nelson SJ, Vigneron DB. Phased Array MR Spectroscopic Imaging of the Brain at 7T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 45.
Xu D, Cunningham CH, Chen AP, Li Y, Kelley DAC, Mukherjee P, Pauly J, Nelson SJ, Vigneron DB. Phased Array 3-D MR Spectroscopic Imaging of the Brain at 7 Tesla. Magn. Reson. Imag. (In Press).
Zierhut ML, Ozturk-Isik E, Chen AP, Vigneron DB, Nelson SJ. HSpectroscopic Imaging of Human Brain at 3T: Comparison of Fast 3D-MRSI Techniques. J. Magn. Reson. Imag. (submitted).

Agarwal SC, P. Beauchesne P, Burghardt A, Hamada Y, Majumdar S "Age-related Changes in Vertebral Trabecular Architecture in Female Japanese Macaques." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007.
Banerjee S, Krug R, Carballido-Gamio J, Kelley DAC, Xu D, Vigneron DB, Majumdar S. Rapid Musculoskeletal MRI at 7 Tesla. Magn Reson Med. 2008; 59:655-660.
Banerjee S, Krug R, Xu D, Kelley DA, Vigneron DB, Majumdar S. Rapid Musculoskeletal MRI at 7 Telsa. ISMRM Workshop: Advances in High Field MR. Pacific Grove, CA, March 2007, p 47.
Banerjee S, Krug R, Xu D, Stahl R, Carvajal L, Link TM, Kelley DAC, Vigneron DB, Majumdar S. In Vivo High Resolution Imagin of the Knee at 7T-Potential for MRI of Osteoarthritis. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 2620.
Banerjee S. Majumdar S. "Methods for Robust Quantification of Trabecular Bone Parameters from Highly Accelerated In Vivo MR Images Obtained by GRAPPA Based Techniques at 3 Tesla and 7 Tesla." Proceedings of the International Society of Magnetic Resonance in Medicine. May, 2007
Banerjee S, Krug R, Carballido-Gamio J, Kelley DA, Xu D, Vigneron DB, Majumdar S. Rapid in vivo musculoskeletal MR with parallel imaging at 7T. Magn Reson Med, Jan/25/2008
Bauer JS, Henning TD, Müeller D, Lu Y, Majumdar S, Link TM. Volumetric quantitative CT of the spine and hip derived from contrast-enhanced MDCT: conversion factors. AJR Am J Roentgenol, May/2007;188(5):1294-301
Bauer JS, Link TM, Burghardt A, Henning TD, Mueller D, Majumdar S, Prevrhal S. Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment. Calcif Tissue Int, Jun/2007;80(6):366-73
Bauer JS, Banerjee S, Henning TD, Krug R, Majumdar S, Link TM. Fast high-spatial-resolution MRI of the ankle with parallel imaging using GRAPPA at 3 T. AJR Am J Roentgenol, Jul/2007;189(1):240-5
Black M, Palermo L, Hue TF, Majumdar S, Bouxsein ML, Rosen CJ "The Effect of Oral Ibandronate Following Weekly PTH: PTH Once Weekly Research Follow-up (POWR II)." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007
Black M, Bouxsein ML, McGowan JA, Ireland C, Majumdar S, Rosen E, Garnero P, Newitt DC, Palermo L, Rosen CJ "PTH Once Weekly Increases BMD and Is Mildly Anabolic in Postmenopausal Osteopenic Women: Results from the PTH Once Weekly Research (POWR) Study." Journal of Bone And Mineral Research, 2006 Abstracts, 28th Annual Meeting, Philadelphia,PA Sept.15-19, 2006. Vol. 21 Suppl 1: S43
Blumenfeld J, Carballido-Gamio J, Krug R, Blezek DJ, Hancu I, Majumdar S. Automatic Prospective Registration of High-Resolution Trabecular Bone Images of the Tibia. Ann Biomed Eng, Aug/17/2007
Blumenkrantz G, Stahl R, Carballido-Gamio J, Link TM, Majumdar S "Longitudinal Changes in the Heterogeneity of Cartilage T2 in Osteoarthritis Subjects." Proceedings of the International Society of Magnetic Resonance in Medicine. May, 2007
Blumenkrantz G, Majumdar S. Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis. Eur Cell Mater, 2007;13:76-86
Blumenkrantz G, Stahl R, Carballido-Gamio J, Zhao S, Lu Y, Munoz T, Hellio Le Graverand-Gastineau MP, Jain SK, Link TM, Majumdar S. The feasibility of characterizing the spatial distribution of cartilage T(2) using texture analysis. Osteoarthritis Cartilage, Mar/10/2008
Bolbos RI, Ma BC, Lin K, Link TM, Majumdar S, Li X "In Vivo MR T1rho Relaxation Time in Bone Marrow Edema Overlying Cartilage in Knees with ACL Injuries." Proceedings of the International Society of Magnetic Resonance in Medicine. May, 2007
Bolbos RI, Zuo J, Banerjee S, Cheng J, Link TM, Ma BC, Li X, Majumdar S. "Interrelationship between trabecular bone and articular cartilage of the knee joint in early OA using parallel MRI and 3T." Osteoarthritis and Cartilage, 2007 World Congress on Osteoarthritis. Volume 15 December 2007
Bolbos RI, Ma BC, Lin K, Link TM, Majumdar S, Li X "In vivo T1rho and T2 quantitative assessment of knee cartilage at 3T following anterior cruciate ligament injury." 54th Annual Meeting of ORS, San Francisco. March 2008
Bolbos RI, Zuo J, Banerjee S, Cheng J, Link TM, Ma BC, Li X, Majumdar S. "Interrelationship between trabecular bone and articular cartilage of the knee joint in early OA using parallel MRI at 3T." 54th Annual Meeting of the Orthopaedic Research Society. 03/2008
Jobke B, Saadat E, Bolbos R, Ries M, Cheng J, Link TM, Li X, Majumdar S. "Mechanism of Disease in early Osteoarthritis: Application of new MR imaging techniques (T1?)." 54th Annual Meeting of the Orthopaedic Research Society. 03/2008
Boudignon BM, Bikle DD, Kurimoto P, Elalieh H, Nishida S, Wang Y, Burghardt A, Majumdar S, Orwoll BE, Rosen C, Halloran BP. Insulin-like Growth Factor-I Stimulates Recovery of Bone Lost after a Period of Skeletal Unloading. J Appl Physiol, Apr/5/2007
Burghardt AJ, Davis K, Link TM, Majumdar S. "[W228] HR-pQCT Assessment of Cortical Bone: Correlations to FE Derived Mechanical Properties." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007.
Burghardt AJ, Kazakia GJ, Majumdar S. A Local Adaptive Threshold Strategy for High Resolution Peripheral Quantitative Computed Tomography of Trabecular Bone. Ann Biomed Eng, Jun/30/2007
Carballido-Gamio J, Li X, Link TM, Majumdar S. "Localized Inter-Subject Comparison of Knee Cartilage Thickness, T2 and T1?: Generating an Atlas of the Knee." Proceedings of the International Society of Magnetic Resonance in Medicine. May, 2007.
Carballido-Gamio J, M. B. Huber*1, K. Fritscher*2, R. Schubert*2, M. Haenni*3, C. Hengg*4, S. Majumdar1, T. M. Link1 "Topological Analysis and Spatial Distribution of Apparent Trabecular Bone in Radiographs Correlate to Biomechanical Bone Properties: An In Vitro Study of the Proximal Femur." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007
Carballido-Gamio J, Xu D, Newitt D, Han ET, Vigneron DB, Majumdar S. Single-shot fast spin-echo diffusion tensor imaging of the lumbar spine at 1.5 and 3 T. Magn Reson Imaging, Jun/2007;25(5):665-70.
Carballido-Gamio J, Bauer JS, Stahl R, Lee KY, Krause S, Link TM, Majumdar S. Inter-subject comparison of MRI knee cartilage thickness. Med Image Anal, Aug 31, 2007
Carpenter D, Newitt D, Krug R, de Papp A, Link T, Majumdar S "Magnetic Resonance Imaging of Trabecular Bone Micro-Architecture at the Hip in Postmenopausal Women." 54th Annual Meeting of ORS, San Francisco. March 2008
Cheng J, Jobke B, Saadat E, Bolbos R, Ries M, Link TM, Li X, Majumdar S, "Local Correlation between in vivo MR T1p mapping and biochemistry and histology in osteoarthritic articular cartilage." Osteoarthritis and Cartilage, 2007 World Congress on Osteoarthritis. Volume 15 December 2007
Cheng J, Ma CB, Teng A, Link TM, Majumdar S, Li X "Quantification of Focal Cartilage Lesions by T1? Magnetic Resonance Imaging." 54th Annual Meeting of ORS, San Francisco. March 2008.
Cheng J, Jobke B, Saadat E, Bolbos R, Ries M, Link TM, Li X, Majumdar S "Local Correlation between in vivo MR T1? Mapping and Biochemistry and Histology in Osteoarthritic Articular Cartilage." 54th Annual Meeting of ORS, San Francisco. March 2008
Davis KA, Burghardt AJ, Link TM, Majumdar S. The Effects of Geometric and Threshold Definitions on Cortical Bone Metrics Assessed by In Vivo High-Resolution Peripheral Quantitative Computed Tomography. Calcif Tissue Int, Oct/20/2007
Easley S, M. Jekir, G. J. Kazakia, S. Majumdar, T.M. Keaveny "Role of Tissue Mineralization, as Measured by Micro-CT, on Apparent and Effective Tissue Elastic Moduli Of Human Trabecular Bone." 53rd Annual Meeting of the Orthopaedic Research Society. 02/2007.
Eckstein F, Buck RJ, Burstein D, Charles HC, Crim J, Hudelmaier M, Hunter D, Hutchins G, Jackson C, Byers Kraus V, Lane NE, Link TM, Majumdar S, Mazzuca S, Prasad PV, Schnitzer TJ, Taljanovic MS, Vaz A, Wyman B, Hellio Le Graverand MP. Precision of 3.0 Tesla Quantitative Magnetic Resonance Imaging of cartilage morphology in a multi center clinical trial. Ann Rheum Dis, Feb/18/2008
Holtzman DJ, Li X, Majumdar S, Ma CB "Quantitative Imaging by MR T1rho and T2 Mapping After Femoral Condyle Articular Cartilage Resurfacing by Mosaicplasty and Microfracture." 54th Annual Meeting of Orthopaedic Research Society (ORS). March 2008
Huber MB, P. V. Patel, J. S. Bauer, S. Prevrhal, S. Majumdar, T. M. Link "Ex-Vivo MR Imaging of Trabecular Bone Structure at 1.5T and 3T." Proceedings of the International Society of Magnetic Resonance in Medicine. May, 2007
Huber MB, J. Carballido-Gamio*1, K. Fritscher*2, R. Schubert*2, M. Haenni*3, C. Hengg*4, S. Majumdar*1, T. M. Link*1 "Morphological Texture Analysis of Radiographs of the Proximal Femur: In Vitro Study Using Biomechanical Strength as a Standard of Reference." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007.
Jobke B, Muche2, A. J. Burghardt1, J. Semler2, G. Delling*3, T. M. Link1, S. Majumdar1. "Teriparatide Administration Following Antiresorptive Therapy (BBB-Study): Changes in 3D Microarchitecture, Mineralization and Remodeling at the Iliac Crest After 6 Months." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007
Kazakia GJ, K. Sekhon, M.D. Ries, S. Majumdar "Regional Variations In Trabecular Bone Morphology And Mineralization In The Osteoarthritic Femoral Head." 53rd Annual Meeting of the Orthopaedic Research Society. 02/2007
Kazakia GJ, Burghardt AJ, Majumdar S. "Assessment of Bone Tissue Mineralization: Evaluation of Polychromatic µCT Mineralization Measurement by Comparison to Synchrotron Radiation µCT." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007.
Kazakia GJ, B. Hyun1, A. Burghardt1, R. Krug1, D. Newitt1, A. DePapp2, T. Link1, S. Majumdar1 "Correlations Between HR-pQCT & High-Field MR In Vivo Bone Imaging." 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). 09/2007
Kazakia GJ, Burghardt AJ, Cheung S, Majumdar S. "Assessment of Mineralization by Polychromatic X-ray MicroCT: Spatially-resolved Comparison with Synchrotron Radiation Imaging." 54th Annual Meeting of ORS, San Francisco. March 2008
Kazakia GJ, Burghardt AJ, Majumdar S. "Accuracy of pQCT-Derived Microachitectural Measures." Journal of Bone And Mineral Research, 2006 Abstracts, 28th Annual Meeting, Philadelphia,PA Sept.15-19, 2006. Vol. 21 Suppl 1: S143
Kazakia GJ, Burghardt AJ, Majumdar S. "A Local Threshold Strategy for Human In Vivo Micro-Tomography." Journal of Bone And Mineral Research, 2006 Abstracts, 28th Annual Meeting, Philadelphia,PA Sept.15-19, 2006. Vol. 21 Suppl 1: S229
Kazakia GJ, Hyun B, Burghardt A, Krug R, Newitt D, de Papp A, Link T, Majumdar S. In Vivo Determination of Bone Structure in Post-Menopausal Women: A Comparison of HR-pQCT and High-Field MR Imaging. J Bone Miner Res, Dec/3/2007
Lin K, Cheng J, Bolbos RI, Carballido-Gamio J, Ries M, Majumdar S, Li X "Orientation Effect of Magnetic Resonance T1p Values in Articular Cartilage." Osteoarthritis and Cartilage, 2007 World Congress on Osteoarthritis. Volume 15 December 2007
Lin K, Cheng J, Bolbos RI, Carballido-Gamio J, Ries M, Majumdar S, Li X "Orientation effect of MR T1rho values in articular cartilage." 54th Annual Meeting of ORS, San Francisco. March 2008
Li X, Youngren JF, Hyun B, Sakkas GK, Mulligan K, Majumdar S, Masharani UB, Schambelan M, Goldfine ID. Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T. Magn Reson Imaging, Aug/1/2007
Li X, Bolbos RI, Cheng J, Lin K, Ma CB, Ries MD, Link TM, Majumdar S "Quantitative assessment of bone marrow edema pattern and associated cartilage in osteoarthritic and ACL-injured knees using MR imaging and spectroscopy." Osteoarthritis and Cartilage, 2007 World Congress on Osteoarthritis. Volume 15 December 2007.
Li X, Benjamin Ma C, Link TM, Castillo DD, Blumenkrantz G, Lozano J, Carballido-Gamio J, Ries M, Majumdar S. In vivoT(1rho) and T(2) mapping of articular cartilage in osteoarthritis of the knee using 3T MRI. Osteoarthritis Cartilage, Feb/15/2007
Li X, Bolbos RI, Cheng J, Lin K, Ma CB, Ries MD, Link TM, Majumdar S "Quantitative Assessment of Bone Marrow Edema Pattern and Associated Cartilage in Osteoarthritic and ACL-Injured Knees Using High Field MR Imaging and Spectroscopy." 54th Annual Meeting of Orthopaedic Research Society (ORS), San Francisco. March 2008
Li X, Han ET, Busse RF, Majumdar S. "In Vivo T1rho Mapping in Cartilage Using 3D Magnetization-Prepared Angle-Modulated Partitioned-K-Space Spoiled Gradient Echo Snapshots (3D MAPSS)." Proceedings of the International Society of Magnetic Resonance in Medicine. May, 2007.
Li X, Han ET, Busse RF, Majumdar S. In vivo T(1rho) mapping in cartilage using 3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS). Magn Reson Med, Feb/2008;59(2):298-307
Majumdar S, Li X, Blumenkrantz G, Saldanha K, Ma CB, Kim H, Lozano J, Link T. MR imaging and early cartilage degeneration and strategies for monitoring regeneration. J Musculoskelet Neuronal Interact, 2007;6(4):382-4
Majumdar S. Magnetic resonance imaging for osteoporosis. Skeletal Radiol, Nov/23/2007.
Majumdar S. Invited Lecture, Imaging Bone Quality, Canadian Bone Strength Working Group, Toronto, Canada - 12/2007
Majumdar S. Invited Lecture, Meet the Professor Session, National Osteoporosis Foundation - 04/2007
Majumdar S. Invited Lecture, Imaging Bone Micro-architecture using MR, ISMRM Educational Sessions - 05/2007
Saadat E, Majumdar S, David M. Rempel, Karen B. King "The effect of frequency and force of in vivo loading on proteoglycan content of rabbit articular cartilage." 54th Annual Meeting of the Orthopaedic Research Society. 03/2008
Saadat, B. Jobke, J. Cheng, X. Li, R.I. Bolbos, M.D. Ries, S. Majumdar, T.M. Link "Diagnostic performance of in vivo MRI for Articular cartilage abnormalities in human osteoarthritic knees using histology with safranin-o staining as standard of reference." Osteoarthritis and Cartilage, 2007 World Congress on Osteoarthritis. Volume 15 December 2007
Saadat, R. Bolbos, J. Cheng, B. Jobke, M.D. Ries, S. Majumdar, X. Li "Detection of Proteoglycan depletion in human osteoarthritic cartilage samples with magnetic resonance T1RHO Imaging." Osteoarthritis and Cartilage, 2007 World Congress on Osteoarthritis. Volume 15 December 2007
Saadat E, Bolbos RI, Cheng J, Jobke B, Ries MD, Majumdar S, Li X "Detection of proteoglycan depletion in human osteoarthritic cartilage samples with magnetic resonance T1rho imaging." 54th Annual Meeting of Orthopaedic Research Society (ORS), San Francisco. March 2008
Sekhon K.K., Kazakia G.J., Burghardt A.J., Hermannsson B.J., Majumdar S. "Effects of Beam Hardening on Mineralization in HRpQCT." 54th Annual Meeting of ORS, San Francisco. March 2008
Sekhon K.K., Kazakia G.J., Burghardt A.J., Hermannsson B.J., Majumdar S. "Effects of Beam Hardening on Mineralization in HRpQCT." 54th Annual Meeting of the Orthopaedic Research Society. 03/2008
Sode M, Burghardt AJ, Majumdar S "Characterizing the Sensitivity of the Structural Measures Index to Resolution and Threshold Methods in Micro-CT." Journal of Bone And Mineral Research, 2006 Abstracts, 28th Annual Meeting, Philadelphia,PA Sept.15-19, 2006. Vol. 21 Suppl 1: S212
Sode M, Burghardt AJ, Nissenson RA, Majumdar S. Resolution Dependence of the Non-metric Trabecular Structure Indices. Bone, Dec/23/2007
Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Hellio Le Graverand-Gastineau MP, Li X, Majumdar S, Link TM. MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthritis Cartilage, Jun/8/2007
Wang Y, Nishida S, Boudignon BM, Burghardt A, Elalieh HZ, Hamilton MM, Majumdar S, Halloran BP, Clemens TL, Bikle DD. The IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone. J Bone Miner Res, May/31/2007
Zuo J, Saadat E, Li X, Majumdar S "Single Voxel Spectroscopy of Intervertebral Disc Degeneration -- An In Vitro Bovine Disc Degeneration Model." 54th Annual Meeting of ORS, San Francisco. March 2008
Zuo J, Li X, Banerjee S, Han E, Majumdar S. Parallel imaging of knee cartilage at 3 Tesla. J Magn Reson Imaging, Oct/2007;26(4):1001-9
Zuo J, Bolbos R, Hammond K, Li X, Majumdar S. Reproducibility of the quantitative assessment of cartilage morphology and trabecular bone structure with magnetic resonance imaging at 7 T. Magn Reson Imaging, Nov/28/2007

Albers MJ, Chen AP, Bok R, Zhang V, Hurd RE, Yen YF, Zierhut ML, Nelson SJ, Vigneron DB, Kurhanewicz J. Monitoring Prostate Cancer Progression in a Transgenic Murine Model Using 3T Hyperpolarized 13C MRSI. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 367.
Albert P, Xu D, Sotto C, Coakley FV, Kurhanewicz J, Vigneron DB "High Resolution MRSI and DTI of Prostate Cancer at 3T." Proc of the Intn’l Soc of Mag Res in Med. 2007
Bartha AI, Yap KR, Miller SP, Jeremy R, Nishimoto M, Vigneron DB, Barkovich AJ, Ferriero DM. MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates. AJNR Am J Neuroradiol. 2007; 28:1015-1021.
Berman JI, Glass HC, Miller SP, Hoisie DJ, Mukherjee P, Ferriero DA, Barkovich AJ, Vigneron DB, Henry RG. Quantitative Fiber Tracking Analysis of the Optic Radiations in Premature Newborns ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 393.
Butler TN, Albers MJ, Keshari K, Swanson MG, Kurhanewicz J "Improved Tissue Metabolite Quantification in 1H HR-MAS Spectroscopy Using the ERETIC Method." Proc of the Intn’l Soc of Mag Res in Med. 2007
Carvajal L, Karpodinis K, Xu D, Vigneron DB. A Continuous Capacitance Coil for High Sensitivity 7T MRI. ISMRM Workshop: Advances in High Field MR. Pacific Grove, CA, March 2007, p 16.
Carvajal L, Karpodinis K, Xu D, Vigneron DB. A Continuous Capacitance Loop Detector for High Sensitivity 7T MRI. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1042.
Carvajal L, Karpodinis K, Newitt DC, Vigneron DB. Tunable Microstrip Loop Arrays for 3T and 7T MRI. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 3264.
Chen AP, Cunningham CH, Xu D, Kelley DAC, Nelson SJ, Vigneron DB. 3D MR Spectroscopic Imaging with Flyback Echo-Planar Readout at 7T. ISMRM Workshop: Advances in High Field MR. Pacific Grove, CA, March 2007, p 69.
Chen AP, Cunningham CH, Xu D, Li Y, Nelson SJ, Vigneron DB. T1 Measurement of Brain Metabolites at 3T with a Saturated-Inversion Recovery Method. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1376.
Chen AP, Hurd RE, Cunningham CM, Albers M, Zierhut ML, Yen YF, Tropp J, Bok R, Nelson SJ, Kurhanewicz J, Vigneron DB. Symmetric Echo Acquisition of Hyperpolarized C-13 MRSI Data in the TRAMP Mouse at 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 538.
Chen AP, Xu D, Sotto C, Coakley FV, Kurhanewicz J, Vigneron DB. High Resolution MRSI and DTI of Prostate Cancer at 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 2887.
Chen A, Albers M, Kohler SJ, Yen YF, Zierhut ML, Hurd RE, Tropp J, Bok R, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MR spectroscopic imaging of TRAMP mouse at 3T. Joint Molecular Imaging Conference, Providence, RI, September 2007, p 115.
Chen AP, Hurd RE, Cunningham CH, Li Y, Zierhurt ML, Bok R, Kurhanewicz J, Nelson SJ, Vigneron DB. Spatially Resolved 13C Hyperpolarized Dynamics MRS using Flyback Echo-Planar Readout Trajectory. 49th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, March 2008, p 60.
Chen AP, Tropp J, Hurd RE, Van Criekinge M, Carvajal L, Kurhanewicz J, Vigneron DB. In vivo Hyperpolarized 13C Spectroscopic Imaging with 1H decoupling. 49th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, March 2008, p 91.
Chen AP, Hurd RE, Cunningham CM, Albers M, Zierhut ML, Yen Y-F, Tropp J, Bok R, Nelson SJ, Kurhanewicz J, Vigneron DB "Symmetric Echo Acquisition of Hyperpolarized C-13 MRSI Data in the TRAMP Mouse at 3T." Proc of the Intn’l Soc of Mag Res in Med. 2007
Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-Initial experience. Magn Reson Med. 2007 Oct 29;58(6):1099-1106
Chen AP, Cunningham CH, Ozturk-Isik E, Xu D, Hurd RE, Kelley DA, Pauly JM, Kurhanewicz J, Nelson SJ, Vigneron DB. High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding. J Magn Reson Imaging. 2007 Jun;25(6):1288-92.
Chen AP, Kurhanewicz J, Bok R, Xu D, Joun D, Zhang V, Nelson SJ, Hurd RE, Vigneron DB. Feasibility of Using Hyperpolarized [l-13C]Lactate as a Substrate for In Vivo Metabolic 13C MRSI Studies. Magn. Reson. Imag. (In Press).
Coakley FV, Chen I, Qayyum A, Westphalen AC, Carroll PR, Hricak H, Chen MH, Kurhanewicz J. Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imaging. BJU Int, Jan/2007;99(1):41-5
Costouros NG, Coakley FV, Westphalen AC, Qayyum A, Yeh BM, Joe BN, Kurhanewicz J. Diagnosis of prostate cancer in patients with an elevated prostate-specific antigen level: role of endorectal MRI and MR spectroscopic imaging. AJR Am J Roentgenol, Mar/2007;188(3):812-6
Cunningham CH, Chen AP, Lustig M, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson SJ, Vigneron DB. Pulse Sequence for Dynamic Volumetric Imaging of Hyperpolarized Metabolic Products. J. Magn. Reson. (In Press).
Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, Pauly JM, Nelson SJ, Vigneron DB. Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson, Aug/2007;187(2):357-62
Dafni H, Kim SJ, Bankson JA, Sankaranarayanapillai M, Ronen SM "Reduction in blood volume and vascular permeability induced by anti-PDGF-R therapy as detected by DCE-MRI." ISMRM. 2007.
Dafni H, Kim SJ, Bankson JA, Sankaranarayanapillai M, Ronen SM "Reduction in blood volume and vascular permeability induced by anti-PDGF-R therapy as detected by CDE-MRI." AACR. 2007.
Dafni H, Ronen SM. "Differential sensitivity to vascular permeability using low-MW and high-MW contrast agents for DCE-MRI." ISMRM 16th Scientific meeting. 05/2008.
Dafni H, Kim S-J, Bankson JA, Sankaranarayanapillai M, Ronen SM. Macromolecular DCE-MRI detects reduced vascular permeability in a prostate cancer bone metastasis model following anti-PDGFR therapy, indicating a drop in VEGFR activation Magnetic Resonance in Medicine, (In Press)
DeIpolyi AR, Mukherjee P, Veeraraghavan S, Berman JI, Zhou S, Lu Y, Henry RG, Vigneron DB, Barkovich AJ. Regional Variation in Human Thalamic Maturation Revealed by Diffusion Tensor Imaging of Premature Newborns. NeuroImage (submitted).
Dicamillo PA, Swanson MG, Tabatabai ZL, Kurhanewicz J, Nelson SJ "Measurement of Citrate Chemical Shift Changes in HR-MAS NMR Spectra of Prostate Biopsies." Proc of the Intn’l Soc of Mag Res in Med. 2007
Dimpy Koul,Ruijun Shen, Jennifer Edge, Yasuko Kondo,Douglas Webb, Jim Bankson, Sabrina M. Ronen, D Lynn Kirkpatrick, Garth Powis, WK Alfred Yung "Cellular and in vivo activity of a new PI3K inhibitor-PX866 for treatment of human glioblastoma." AACR Annual meeting. 04/2008.
Gerion D, Herberg J, Bok R, Gjersing E, Ramon E, Maxwell R, Kurhanewicz J, Budinger TF, Gray JW, Shuman MA, Chen FF. Paramagnetic silica-coated nanocrystals as an advanced MRI contrast agent Journal of Physical Chemistry, 2007;111:12542-12551
Glass HC, Miller SP, Fujimoto S, Ceppi-Cozzio C, Bartha A, Vigneron DB, Barkovich AJ, Glidden DV, Ferriero DM. White Matter Injury is Associated with Impaired Gaze in Premature Infants. Pediatr Neuro 2008; 38:10-15.
Glenn OA, Ludeman N, Berman JI, Wu Y, Bartha A, Vigneron DB, Ferriero DM, Barkovich AJ, and Henry RG. Diffusion tensor MR imaging tractography of the pyramidal tracts correlates with clinical motor function in children with congenital hemiparesis. AJNR Am J Neuroradiol. 2007 Oct;28(9):1796-802.
Hess CP, Xu D, Kelley DAC, von Morze C, Ledden PJ, Vigneron DB, Mukherjee, P. High Resolution Imaging of the Human Hippocampal Complex using 7T MRI: Initial Experience. Neuroimage, (submitted).
Hom JJ, Coakley FV, Simko JP, Lu Y, Qayyum A, Westphalen AC, Schmitt LD, Carroll PR, Kurhanewicz J. High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experience. Radiology, Feb/2007;242(2):483-9
Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Hurd RE, Nelson S, Kurhanewicz J, Vigneron DB. Initial In Vivo Carbon-13 Dynamic Spectroscopy of Rat Liver and Kidney at 3T with Hyperpolarized 13C-1-Pyruvate. Joint Molecular Imaging Conference, Providence, RI, September 2007, p 305.
Hu S, Lustig M, Chen AP, Crane J, Kerr A, Kelley DAC, Hurd R, Kurhanewicz J, Nelson SJ, Pauly JM, Vigneron DB. Hyperpolarized Carbon-13 Flyback 3D-MRSI with Compressed Sensing for Resolution Enhancement. 49th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, March 2008.
Hu S, Lustig M, Chen AP, Crane J, Kerr A, Kelley DAC, Hurd RE, Kurhanewicz J, Nelson SJ, Pauly JM, Vigneron DB. Compressed Sensing for Resolution Enhancement of Hyperpolarized 13C Flyback 3D-MRSI. J. Magn Reson. (In Press).
Joe BN, Swanson MG, Vahidi K, Zektzer A, Chen M-H, Clifton M, Butler T, Keshari K, Kurhanewicz J "1.5T In Vivo 1H MRS for Evaluation of Fetal Lung Maturity: Technical Feasibility Study." Proc of the Intn’l Soc of Mag Res in Med. 2007
Keshari K, Swanson M, Simko J, Vigneron D, Nelson SJ, Kurhanewicz J. Quantification of Choline and Ethanolamine Containing Phospholipids in Healthy and Malignant Prostate Tissues. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 2893.
Keshari KR, Kurhanewicz J, Bok R, Jeffries R, Van Criekinge M, Vigneron DB, Gamcsik MP, Macdonald JM. Hyperpolarized 13C NMR and a Novel 3D Bioreactor for the Real Time Characterization of a Hepatoma Cell Line. 49th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, March 2008, p 186.
Keshari KR, Macdonald JM, Chen A, Bok R, Van Criekinge M, Ronen SM, Vigneron DB, Nelson SJ, Kurhanewicz J "Detection of pyruvate metabolism in a prostate cancer cell line using a novel NMR-compatible bioreactor and hyperpolarized 13C MRS." ISMRM 16th Scientific meeting. 05/2008.
Keshari KR, Lotz JC, Link TM, Hu S, Majumdar S, Kurhanewicz J. Lactic acid and proteoglycans as metabolic markers for discogenic back pain. Spine, Feb/1/2008;33(3):312-7
Kim DH, Chung SW, Vigneron DB, Barkovich AJ, Glenn O. In Utero Fetal Brain Diffusion Weighted Imaging. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 567.
Kim DH, Vahidi K, Caughey A, Coakley F, Vigneron DB, Kurhanewicz J, Joe BN. 1.5T In Vivo 1H MRS for Evaluation of Fetal lung Maturity: Technical Feasibility Study. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 569.
Kim Y, Hsu IC, Lessard E, Kurhanewicz J, Noworolski SM, Pouliot J. Class solution in inverse planned HDR prostate brachytherapy for dose escalation of DIL defined by combined MRI/MRSI. Radiother Oncol, Dec/14/2007
Kim D-H, Chung S, Vigneron DB, Barkovich AJ, Glenn O. Diffusion Weighted Imaging of the Fetal Brain In Vivo, Magn. Reson. In Med. 2008; 38:10-15.
Kim D-H, Vahidi K, Caughey AB, Coakley F, Vigneron DB, Kurhanewicz J, Joe B. In Vivo 1H MRS of Fetal Amniotic Fluid and Lung at 1.5T: Technical Feasibility Study. Radiology (submitted).
Kim D-H, Gu M, Cunningham CH, Chen AP, Baumer F, Glenn O, Vigneron DB, Spielman D, Barkovch AJ. Fast 3D 1H MRSI of Pediatric Brain With Motor Dysfunction. J. Magn. Reson. Imag. (submitted).
Kohler SJ, Yen Y, Wolber J, Chen AP, Albers MJ, Bok R, Zhang V, Tropp J, Nelson S, Vigneron DB, Kurhanewicz J, Hurd RE. In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate. Magn Reson Med. 2007 Jul;58(1):65-9.
Kurhanewicz J. Invited Lecture, High Field Clinical Applications – Prostate Cancer Imaging, International Society in Magnetic Resonance in Medicine, Berlin, Germany - 2007
Kurhanewicz J. Invited Lecture, Technical Advances in Body MR – Body MR Spectroscopy, International Society in Magnetic Resonance in Medicine, Berlin, Germany - 2007
Kurhanewicz J. Invited Lecture, Current Clinical Status of Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopic Imaging (MRSI) of Prostate Cancer, KMH Cardiology & Diagnostic Centres Physicians Lecture Series, Toronto, Canada - 2007
Kurhanewicz J. Invited Lecture, Magnetic Resonance Imaging of Prostate Cancer Patients Receiving Radiation Therapy, 13th International Congress of Radiation Research, Los Angeles, CA - 2007
Kurhanewicz J. Invited Lecture, Ending the ERA of Blind Cancer Care and Creating a Future of Image-Guided, Minimally-Invasive Diagnosis and Treatment, The Fourth AdMeTech Conference, Washington, DC - 2007
Kurhanewicz J. Invited Lecture, Multiparametric Magnetic Resonance Imaging of Prostate Cancer, The Fourth AdMeTech Conference, Washington, DC - 2007
Kurhanewicz J. Invited Lecture, Magnetic Resonance Imaging of Prostate Cancer – Current Status, 2007 National Conference on Prostate Cancer - The Prostate Cancer Research Institute, Los Angeles, CA - 2007
Kurhanewicz J. Invited Lecture, Hyperpolarized 13C MRSI for the Detection and Characterization of Prostate Cancer Prior to and After Therapy, Imaging in 2020, Jackson Hole, WY - 2007
Kurhanewicz J. Grand Rounds, Current and New Directions in Prostate Cancer Magnetic Resonance Imaging, Dana-Farber Cancer Institute, Boston, MA - 2007
Kurhanewicz J. Invited Lecture, New MR Biomarkers of Prostate Cancer, Urologic Clinical Conference at UCSF Cancer Center, San Francisco, CA - 2007
Kurhanewicz J, Vigneron D, Carroll P, Coakley F. Multiparametric magnetic resonance imaging in prostate caner: present and future. Combined MRI/Magnetic Resonance Spectroscopic Imaging. Current Opinion in Urology. 2008, 18:71-77.
Kurhanewicz J, Bok R, Nelson SJ, Vigneron DB. The Current and Potential Applications of Clinical 13C Magnetic Resonance Spectroscopy. J. Nucl. Med. 2008; 49:341-344.
Larson PEZ, Hu S, Chen AP, Zierhut ML, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-selective B1-insensitive Saturation and Inversion Pulses for Isolating in vivo Time Constants in Dynamic Hyperpolarized 13C Spectroscopy. 49th Experimental Nuclear Magnetic Resonance Conference, Pacific Grove, CA, March 2008, p 74.
McKenna DA, Coakley FV, Westphalen AC, Zhao S, Lu Y, Webb EM, Pickett B, Roach M, Kurhanewicz J. Prostate Cancer: Role of Pretreatment MR in Predicting Outcome after External-Beam Radiation Therapy--Initial Experience. Radiology, Feb/7/2008
McKenna DA, Coakley FV, Westphalen AC, Zhao S, Lu Y, Webb EM, Pickett B, Roach M, Kurhanewicz J "Role of pre-treatment mr imaging in the prediction of patient outcome after external beam radiotherapy for prostate cancer." Journal of Urology. (177:593-593) , 2007
Metcalf M, Pelletier D, Xu D, Carvajal L, Srinivasan R, Kelly DAC, Nelson SJ, Vigneron DB. High Resolution and Diffusion 7T MR Imaging of Multiple Sclerosis Patients. ISMRM Workshop: Advances in High Field MR. Pacific Grove, CA, March 2007, p 56.
Metcalf M, Pelletier D, Xu D, Carvajal L, Okuda DT, Srinivasan R, Kelley DAC, Nelson SJ, Vigneron DB. High-Resolution In-Vivo Imaging of Multiple Sclerosis at 7T ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 266.
Metcalf M, Pelletier D, Xu D, Okuda DT, Srinivasan R, Kelley DAC, Nelson SJ, Vigneron DB. Diffusion Tensor Imaging at 7 Tesla: Initial Application to Multiple Sclerosis. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 2180.
Metcalf M, Pelletier D, Xu D, Carvajal L, Okuda DT, Srinivasan R, Kelley DAC, Nelson SJ, Vigneron DB. Initial Applications of 7T MR Imaging to Multiple Sclerosis. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 46.
Miller SP, McQuillen PS, Hamrick S, Xu D, Charlton NN, Glidden D, Karl T, Barkovich AJ, and Vigneron DB. Abnormal Brain Development in Newborns with Congenital Heart Disease Prior to Cardiac Surgery. N Engl J Med 2007; 357(19):1928-1938.
Modlesky CM, Majumdar S, Dudley GA. Trabecular bone microarchitecture in female collegiate gymnasts. Osteoporos Int, Dec/12/2007
Mueller-Lisse UG, Swanson MG, Vigneron DB, Kurhanewicz J. Magnetic resonance spectroscopy in patients with locally confined prostate cancer: Association of prostatic citrate and metabolic atrophy with time on hormone therapy, PSA level, and biopsy Gleason score. European Radiology 2007; 17:371-378.
Mukherjee P, Hess CP, Xu D, Han ET, Kelley DA, Vigneron DB. Development and initial evaluation of 7-T q-ball imaging of the human brain. Magn Reson Imaging. 2008; 26(2):171-80.
Nelson SJ, Xu D, Hammond KE, Lup JM, Chen AP, Cunningham CH, Kelley DAC, Chang SM, Pauly JM, Vigneron DB. 3-D MRSI of Patients with Gliomas Using a 7T Whole Body MR Scanner. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1241.
Nelson SJ, Chen AP, Bok R, Albers M, Zierhut ML, Kurhanewicz J, Vigneron DB, Kohler S, Yen YF, Tropp J, Gram A, Wolber J, Dirven H, Hurd RE. Hyperpolarized C-13 MRSI Data of Dog Prostate at 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 536.
Nelson SJ, Chen AP, Bok R, Albers M, Zierhut ML, Kurhanewicz J, Vigneron DB, Kohler S, Yen Y-F, Tropp J, Gram A, Wolber J, Dirven H, Hurd RE "Hyperpolarized C-13 MRSI Data of Dog Prostate at 3T." Proc of the Intn’l Soc of Mag Res in Med. 2007
Noworolski SM, Khatibi K, Sotto C, Chen AP, Lee D, Vigneron DB, Kurhanewicz J. Evaluation of Serial MRI/MRSI of the Prostae in Prostate Cancer Patients Receiving Dutasteride, an Antiandrogen Therapy. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 796.
Noworolski SM, Vigneron DB, Chen AP and Kurhanewicz J “Combined Dynamic Contrast-Enhanced MRI and MR Diffusion Imaging to Distinguish Between Glandular and Stromal Prostatic Tissues” Magn Reson Imag, (In Press).
Noworolski SM, Crane JC, Vigneron DB, Kurhanewicz J. A Clinical Comparison of Rigid and Inflatable Endorectal Coil Probes for MRI and 3D MRSI of the Prostate. J. Magn Reson Imag. (submitted).
Noworolski SM, Merriman R, Ferrell L, Vigneron DB, Qayyum A. Respiratory Motion Corrected Proton Magnetic Resonance Spectroscopy with Comparison to Pathology in Non-Alcoholic Fatty Liver Disease. J. Magn Reson Imag. (submitted).
Pai, Blumenkrantz G, Majumdar S, Link TM, Ma CB, Li X. "Assessment On Spatial Heterogeneity Of Cartilage T1rho And T2 In Patients With Osteoarthritis Using Texture Analysis." 53rd Annual Meeting of the Orthopaedic Research Society. 02/2007.
Patel PV, Eckstein F, Carballido-Gamio J, Phan C, Matsuura M, Lochmüller EM, Majumdar S, Link TM. Fuzzy Logic Structure Analysis of Trabecular Bone of the Calcaneus to Estimate Proximal Femur Fracture Load and Discriminate Subjects with and without Vertebral Fractures using High-Resolution Magnetic Resonance Imaging at 1.5 T and 3 T. Calcif Tissue Int, Aug/20/2007
Pels P, Zierhut ML, Park Ilwoo, Yen YF, Chen AP, Bok R, Zhang V, Albers M, Vigneron DB, Kurhanewicz J, Hurd R, Nelson SJ. Reconstructing Metabolic Images from Hyperpolarized 13C 3T MRSI Data Using AMARES for Reduced FID Sampling. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 194.
Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. Conditional Expression of a Gi-coupled Receptor in Osteoblasts Results in Trabecular Osteopenia. Endocrinology, Nov/29/2007
Piper SL, Saldanha K, Majumdar S, Kim H. "3T MRI Does Not Affect the Viability and Proliferation of Human Articular Chondrocytes." 54th Annual Meeting of the Orthopaedic Research Society. 03/2008
Purcell DD, Von Morze C, Hess C, Hetts S, Vigneron DB, Mukherjee P. 7T Intracranial 3D Time-of-Flight MR Angiography: Improved Contrast-to-Noise Ratio and Vessel Delineation Compared to 3T. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 99.
Rajesh A, Coakley FV, Kurhanewicz J. 3D MR spectroscopic imaging in the evaluation of prostate cancer. Clin Radiol, Oct/2007;62(10):921-9.
Ratiney H, Noworolski SM, Sdika M, Srinivasan R, Henry RG, Nelson SJ, Pelletier D. Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imagingdata. MAGMA. 2007 Jun;20(3):143-55. Epub 2007 Jun 30.
Ronen, SM, Bankson, J, Koul, D, Sankarananrayanapillai, M, Webb, D, Kinglsely, C, Delacerda, J, Ede, J, Yung, A, Powis, G "Treatment with the novel PI3K inhibitor PX-866 results in 1H MRS detectable changes in a glioma model in vivo." ISMRM. 2007.
Ronen SM. Invited Lecture, Evaluating pathways - inhibition and regulation by MRS, International Society for Magnetic Resonance in Medicine, Seattle, WA - 05/2007
Ronen SM. Invited Lecture, Therapy assessment in animal models with MRS, International Society for Magnetic Resonance in Medicine, Toronto, Canada - 05/2008
Ross J, Tong WP, Kaluarachchi K, Ronen SM "Detection of metabolic effects of fatty acid synthase inhibition by magnetic resonance spectroscopy." ISMRM. 2007.
Ross J, Tong WP, Kaluarachchi K, Ronen SM "Detection of metabolic effects of fatty acide synthase inhibition by magnetic resonance spectroscopy." AACR. 2007.
Sankaranarayanapillai M, Kaluarachchi K, Ronen SM "C MRS detection of increased choline metabolism following HDAC inhibition." ISMRM. 2007.
Sankaranarayanapillai M, Bankson JA, Yuan Q, Dafni H, Webb D, Pal A, Jackson EF, Gelovani J, Tong WP, Ronen SM "Histone deacetylase inhibition by MRS: Comparison of in vitro and in vivo studies." ISMRM 16th Scientific meeting. 05/2008.
Sankaranarayanapillai M, Tong W, Yuan Q, Bankson J, Dafni H, Bornmann W, Soghomonyan S, Pal A, Ramirez M, Webb D, Kaluarachchi K, Gelovani J, Ronen SM. Monitoring histone deacetylase inhibition in vivo: a noninvasive magnetic resonance spectroscopy method Molecular Imaging, (In Press)
Swanson MG, Keshari KR, Tabatabai ZL, Simko JP, Tessem M-B, Joun DJ, Shinohara K, Kurhanewicz J "HR-MAS Spectroscopy of Post-Radiation Prostate Biopsy Tissues." Proc of the Intn’l Soc of Mag Res in Med. 2007
Tessem MB, Keshari KR, Joun D, Tabatabai ZL, Simko J, Shinohara K, Nelson SJ, Vigneron DB, Swanson MG, Gribbestad IS, Kurhanewicz J. Lactate and Alanine as Metabolic Biomarkers for Prostate Cancer in TRUS-Guided Biopsies Measured by 1H HR-MAS Spectroscopy. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 798.
Testa C, Schiavina R, Lodi R, Salizzoni E, Corti B, Farsad M, Kurhanewicz J, Manferrari F, Brunocilla E, Tonon C, Monetti N, Castellucci P, Fanti S, Coe M, Grigioni WF, Martorana G, Canini R, Barbiroli B. Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT. Radiology, Sep/2007;244(3):797-806
Veeraraghavan S, Miller SP, Mukherjee P, Xu D, Barkovich A, Vigneron DB. Determining Normal Diffusion Tensor Imaging Parameters in Premature Newborns. ASNR 45th Annual Meeting, Chicago, IL, June 2007, p 126.
Vigneron DB. MR Technology Implementation-Research Perspective. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, Special Symposium.
Von Morze C, Tropp J, Banerjee S, Xu D, Karpodinis K, Carvajal L, Hess CP, Mukherjee P, Majumdar S, Vigneron DB. An Eight-Channel, Non-Overlapping Phased Array Coil With Capacitive Decoupling For Parallel MRI At 3 T. Concepts in Magnetic Resonance, Part B: (Magnetic Resonance Engineering) 2007; 31B: 37-43.
Von Morze C, Xu D, Purcell D, Hess CP, Mukherjee P, Saloner D, Kelley D, Vigneron DB. Intracranial Time-of-Flight MR Angiography at 7T with Comparison to 3T. J Magn Reson Imaging. 2007 Oct;26(4):900-4.
Von Morze C, Purcell D, Banerjee S, Xu D, Mukherjee P, Kelley DAC, Majumdar S, Vigneron DB. High Resolution Intracranial Time-Of-Flight MRA At 7T Using Autocalibrating Parallel Imaging. J Magn Reson Imaging (submitted).
VonMorze C, Xu D, Purcell DD, Hess CP, Mukherjee P, Saloner D, Kelley DAC, Vigneron DB. Intracranial Time-Of-Flight MR Angiography at 7T with Comparison to 3T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 681.
Wang ZJ, Vigneron DB, Miller SP, Mukherjee P, Charlton NN, Lu Y, Barkovich AJ. Brain Metabolite Levels Assessed by Lactate-Edited MR Spectroscopy in Premature Neonates with and without Pentobarbital Sedation. AJNR Am J Neuroradiol. (In Press).
Westphalen AC, Coakley FV, Qayyum A, Swanson M, Simko JP, Lu Y, Zhao S, Carroll PR, Yeh BM, Kurhanewicz J. Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging. Radiology, Jan/2008;246(1):177-84
Xu D, Li Y, Chen AP, Hurd R, Crane JC, Nelson SJ, Vigneron DB. 2D J-Resolved Spectroscopy 7T. ISMRM Fifteenth Scientific Meeting, Berlin, Germany, May 2007, p 1365.
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