Velmurugan Jayabal, MBBS, PhD
Specialist
Biography
Dr. Velmurugan Jayabal completed his internship in general medicine and general surgery, earning his medical degree from Coimbatore Medical College in India. He furthered his academic pursuits by achieving an M.D-Ph.D in Clinical Neurosciences at the distinguished National Institute of Mental Health and Neurosciences (NIMHANS) in Bangalore, India. There, he received comprehensive clinical training in epilepsy, focusing his research on innovative electrophysiological biomarkers such as high-frequency oscillations and functional connectivity to pinpoint the epileptogenic zone and forecast outcomes. Additionally, Dr. Jayabal was awarded a Fulbright Fellowship to advance his research during his M.D-Ph.D.
Following his doctoral studies, Dr. Jayabal pursued post-doctoral research at Aix-Marseille University and La Timone Hospital, where he investigated the efficacy of source reconstruction and network retrieval, as well as the relationship between magnetoencephalography (MEG) and intracranial stereoelectroencephalography (SEEG) signals in epilepsy patients.
At UCSF, Dr. Jayabal's work focuses on MEG/EEG imaging of brain activity and functional connectivity, including detection, source localization of epileptiform events, functional mapping, interpretation of neurophysiology findings, and generating MSI reports. He also provides training to staff and students on best practices and interpretation of MEG and EEG data collection, processing, and analysis.
Dr. Jayabal's research primarily revolves around investigating physiological and pathological network and substrate alterations in patients with epilepsy, brain tumors, dementia, and other neurological disorders. A significant portion of his research endeavors centers on utilizing MEG brain imaging to identify biomarkers, improve the localization of epileptogenic zones, and understand the temporospatial profile in patients with neuropsychiatric disorders.
Education
Post doctoral fellowship, 06/2022 - Clinical Neurophysiology - Epilepsy and simultaneous MEG-SEEG, signal and image processing, Aix Marseille University- University Hospital La Timone
MD/PhD (Clinical neurosciences), 04/2018 - Neurology,Epilepsy,Clinical neurosciences (EEG, MEG, ECoG), National Institute of Mental Health and Neuroscience (NIMHANS)
Fulbright fellowship, 06/2017 - Epilepsy and MEG, electrophysiological signal processing, University of California San Francisco (UCSF)
Bachelor of medicine, bachelor of surgery (M.B.B.S), 03/2010 - General medicine and surgery, Coimbatore Medical College
Honors and Awards
'International Brain Research organization (IBRO) travel grant, American Epilepsy Society meeting, Chicago, USA, 2021
'Iconic health care leader award-Neurologist, Asia GCC foundation, India, 2021
Scholarship prize for cadaveric workshop and SPINECON, All India Institute of Medical Sciences (AIIMS), New Delhi, India, 2019
Welcome Grant for Postdoctoral fellows, Marseille city council, Marseille, France, 2019
Emerging nations travel award, BIOMAG conference, Philadelphia, 2018
Travelling fellowship award, Indian Academy of Neurology (IAN), 2018
Best epilepsy original research paper award, Indian Academy of Neurology (IAN) at Raipur, India, 2018
International Federation of Clinical Neurophysiology (IFCN) fellowship, International Clinical Congress on Neurophysiology (ICCN), Washington, India, 2018
Best epilepsy original research paper award, Indian Academy of Neurology (IAN), Chennai, India, 2017
Junior travelling fellowship award, World Federation of Neurology at the AES, Washington, United States, 2017
Fulbright fellowship award, University of California San Francisco (UCSF), United States, 2016-2017
Travel bursary award, International League against epilepsy (ILAE), 2016
Scholarship Prize, University of Albert Ludwig, Germany, 2016
Travel award, University of Freiburg, Germany, 2016
Junior travelling fellowship award, World Federation of Neurology (WFN) at the Asian-Oceanic Epilepsy Congress, Hong Kong, 2016
American Epilepsy Society fellow and EpiPORT (Epilepsy Patient oriented research training) fellow, American epilepsy society (AES), 2015-2016
International League Against Epilepsy (ILAE) bursary award, Advanced VIREPA (Virtual Epilepsy Academy) in “EEG in the diagnosis & management of epilepsy", 2015
Suzanne and Peter Berry International Travel Award, American Epilepsy Society (AES), United States, 2015
Council of Scientific & Industrial Research (CSIR) international travel grants, Organization for Human brain mapping conference, in Miami, United States, 2015
T.S. Srinivasan-NIMHANS Foundation grant, TVS group, Chennai, India, 2014-2017
Indian epilepsy school educational bursary award, Indian epilepsy school at Hyderabad, India, 2014
International Federation of Clinical Neurophysiology (IFCN) fellowship, International Clinical Congress on Neurophysiology (ICCN), Berlin, Germany, 2014
ACIAN trust scholarship prize, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India, 2014
Publications
Mishra R, Mariyappa N, Rao Malla B, Arivazhagan A, Mishra B, Gautham B, Chowdary Mundlamuri R, Jayabal V, Raghavendra K, Asranna A, Viswanathan LG, Sadashiva N, Bharath RD, Saini J, Nagaraj C, Mangalore S, Karthik K, Rajeswaran J, Kumar K, Mahadevan A, Sinha S. Localisation of eloquent cortex using magnetoencephalography and its clinical implications. Int J Neurosci. 2023 Oct 12; 1-13.
Víctor J. López-Madrona, Samuel Medina Villalon, Jayabal Velmurugan, Aurore Semeux-Bernier, Elodie Garnier, Jean-Michel Badier, Daniele Schön, Christian-G. Bénar. Reconstruction and localization of auditory sources from intracerebral SEEG using independent component analysis. 2023.
Velmurugan J, Badier JM, Pizzo F, Medina Villalon S, Papageorgakis C, López-Madrona V, Jegou A, Carron R, Bartolomei F, Bénar CG. Virtual MEG sensors based on beamformer and independent component analysis can reconstruct epileptic activity as measured on simultaneous intracerebral recordings. Neuroimage. 2022 Oct 18; 264:119681.
Aruna R, Mariyappa N, Sinha S, Nagappa M, Velmurugan J, Saini J, Bindu PS, Mathuranath PS, Thennarasu K, Satishchandra P, Taly AB. Insights from Magnetic Evoked Field Analysis in Patients with Wilson's Disease. Neurol India. 2022 Sep-Oct; 70(5):1963-1970.
López-Madrona VJ, Medina Villalon S, Badier JM, Trébuchon A, Jayabal V, Bartolomei F, Carron R, Barborica A, Vulliémoz S, Alario FX, Bénar CG. Magnetoencephalography can reveal deep brain network activities linked to memory processes. Hum Brain Mapp. 2022 10 15; 43(15):4733-4749.
Mukheem Mudabbir MA, Mundlamuri RC, Aravind KR, Narayanan M, Alladi S, Shivashankar N, Kenchaiah R, Asranna A, Viswanathan LG, Bhargava GK, Velmurugan J, Thennarasu K, Rajan J, Kulanthaivelu K, Bharath RD, Saini J, Sinha S. EEG-based P300 in mesial temporal lobe epilepsy and its correlation with cognitive functions: A case-control study. Epilepsy Behav. 2021 10; 123:108279.
Christian-GeorgeBénar, JayabalVelmurugan, Victor J.López-Madrona, FrancescaPizzo, Jean-MichelBadier. Detection and localization of deep sources in magnetoencephalography: A review. Current Opinion in Biomedical Engineering. 2021; 18(100285).
Gautham B, Abdulhak A, Mundlamuri RC, Narayanan M, Jayabal V, Kenchaiah R, Asranna A, Dawn BR, Jitender S, Nagaraj C, Mangalore S, Karthik K, Sadashiva N, Mahadevan A, Rajeswaran J, Kumar K, Arivazhagan A, Rao MB, Sinha S. Magnetic source imaging in presurgical evaluation of paediatric focal drug-resistant epilepsy and its predictive value of surgical outcome in lesional cases: A single-centre experience from South India. Seizure. 2021 Oct; 91:22-28.
Prabhu P, Karunakar AK, Sinha S, Mariyappa N, Bhargava GK, Velmurugan J, Anitha H. Content-Based Estimation of Brain MRI Tilt in Three Orthogonal Directions. J Digit Imaging. 2021 06; 34(3):760-771.
Bhanot N, Mariyappa N, Anitha H, Bhargava GK, Velmurugan J, Sinha S. Seizure detection and epileptogenic zone localisation on heavily skewed MEG data using RUSBoost machine learning technique. Int J Neurosci. 2022 Oct; 132(10):963-974.
Mukheem Mudabbir MA, Mundlamuri RC, Mariyappa N, Aravind Kumar R, Velmurugan J, Bhargava GK, Suvarna A, Shivashankar N, Raghavendra K, Asranna A, Thennarasu K, Jamuna R, Rose Dawn B, Saini J, Sinha S. P300 in mesial temporal lobe epilepsy and its correlation with cognition - A MEG based prospective case-control study. Epilepsy Behav. 2021 01; 114(Pt A):107619.
Velmurugan J, Nagarajan SS, Mariyappa N, Mundlamuri RC, Raghavendra K, Bharath RD, Saini J, Arivazhagan A, Rajeswaran J, Mahadevan A, Malla BR, Satishchandra P, Sinha S. Magnetoencephalography imaging of high frequency oscillations strengthens presurgical localization and outcome prediction. Brain. 2019 11 01; 142(11):3514-3529.
Cai C, Xu J, Velmurugan J, Knowlton R, Sekihara K, Nagarajan SS, Kirsch H. Evaluation of a dual signal subspace projection algorithm in magnetoencephalographic recordings from patients with intractable epilepsy and vagus nerve stimulators. Neuroimage. 2019 03; 188:161-170.
Velmurugan Jayabal, Srikantan Nagarajan, Mariyappa Narayanan, Ravi Shankar, Thennarasu Kandavel, Ravindranadh C. Mundlamuri, Raghavendra Kenchaiah, Rose Dawn Bharath, Jitender Saini, Arivazhagan Arimappamagan, Rajeswaran Jamuna, Mahadevan Anita, Bhaskar Rao Malla, Satishchandra Parthasarathy, Sinha Sanjib. T115. Magnetoencephalographic imaging of ictal high-frequency oscillations (80–200 Hz) in medically refractory epilepsy: Clinical Neurophysiology. 2018; 129(1):e47.
Sanjib Sinha, Velmurugan Jayabal, N Mariyappa, V Gadad, P Satishchandra, Srikantan Nagarajan. Association of default mode network (DMN) regions at absence seizure onset unconstrained by their frequency confinement : Epilepsia. 2017; 58(S7).
Gadad V, Sinha S, Mariyappa N, Velmurugan J, Chaitanya G, Saini J, Thennarasu K, Satishchandra P. Source analysis of epileptiform discharges in absence epilepsy using Magnetoencephalography (MEG). Epilepsy Res. 2018 02; 140:46-52.
Velmurugan J, Nagarajan SS, Mariyappa N, Ravi SG, Thennarasu K, Mundlamuri RC, Raghavendra K, Bharath RD, Saini J, Arivazhagan A, Rajan J, Mahadevan A, Rao MB, Satishchandra P, Sinha S. Magnetoencephalographic imaging of ictal high-frequency oscillations (80-200 Hz) in pharmacologically resistant focal epilepsy. Epilepsia. 2018 01; 59(1):190-202.
Jayabal V, Pillai A, Sinha S, Mariyappa N, Satishchandra P, Gopinath S, Radhakrishnan K. Role of magnetoencephalography and stereo-electroencephalography in the presurgical evaluation in patients with drug-resistant epilepsy. Neurol India. 2017; 65(Supplement):S34-S44.
Gadad V, Sinha S, Mariyappa N, Chaithanya G, Jayabal V, Saini J, Thennarasu K, Satishchandra P. Source localization of epileptiform discharges in juvenile myoclonic epilepsy (JME) using magnetoencephalography (MEG). Epilepsy Res. 2017 01; 129:67-73.
Velmurugan J, Sinha S, Nagappa M, Mariyappa N, Bindu PS, Ravi GS, Hazra N, Thennarasu K, Ravi V, Taly AB, Satishchandra P. Combined MEG-EEG source localisation in patients with sub-acute sclerosing pan-encephalitis. Neurol Sci. 2016 Aug; 37(8):1221-31.
Chaitanya G, Santosh NS, Velmurugan J, Arivazhagan A, Bharath RD, Mahadevan A, Nagappa M, Bindu PS, Rao MB, Taly AB, Satishchandra P, Sinha S. Ictal Generalized EEG Attenuation (IGEA) and hypopnea in a child with occipital type 1 cortical dysplasia - Is it a biomarker for SUDEP? Ann Indian Acad Neurol. 2015 Jan-Mar; 18(1):103-7.
Velmurugan J, Sinha S, Satishchandra P. Magnetoencephalography recording and analysis. Ann Indian Acad Neurol. 2014 Mar; 17(Suppl 1):S113-9.
