Research Directions

The Majumdar/Link Lab is part of the Musculoskeletal and Quantitative Imaging Research Group (MQIR) at UCSF.

Osteoarthritis

• Analysis of the nonsymptomatic incidence cohort of the Osteoarthritis Initiative in relation to physical activity
• Characterizing the spatial distribution of cartilage T2 using texture analysis
• Interrelationship between trabecular bone and articular cartilage of the knee joint in early OA
• Quantitative assessment of the meniscus using 3 tesla MRI
• Small animal studies in osteoarthritis
• Weight-bearing MRI for analysis of knee OA

Bone and Cartilage Characterization

• 3-D image registration of MR images for the analysis of trabecular bone parameters
• Coil correction of magnetic resonance images for trabecular bone analysis
• Ex vivo quantitative µCT imaging of bone composition
• In vivo HR-pQCT and MRI structure measurements and visualization of macro-porosity
• Quantitative assessment of cartilage morphology and trabecular bone structure with magnetic resonance imaging at 7 tesla
• Quantification of cortical bone water using ultrashort echo-time radial MRI

Spine

• In vivo 3 tesla magnetic resonance T1ρ relaxation mapping of intervertebral discs
• Identification of magnetic resonance spectroscopic markers for intervertebral disc degeneration and correlation to biochemical findings

Stem Cells

• MR-based tracking of iron oxide labeled mesenchymal stem cells for tissue engineering applications

Wrist

• 7 tesla imaging of the wrist